Development and application of a method to investigate drug-metabolizing enzyme inhibitors using sparteine for probe of cytochrome P450 2D6 and tris(2,2′-bipyridine)ruthenium(II)-electrogenerated chemiluminescence detection

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 2, 2011, Pages 249-253

  Shibano, Yuu ^a   Taki, Shiwori ^a   Miyamoto, Aoi ^a   Uchikura, Kazuo ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Column switching HPLC; Cytochrome P450 2D6; Metixene; tris(2,2 bipyridine)ruthenium(II)

Indexed keywords

ADRENALIN; AMIODARONE; BARBITAL; CHLORDIAZEPOXIDE; CHLORPHENIRAMINE; CIMETIDINE; CLOMIPRAMINE; CYTOCHROME P450 2D6; CYTOCHROME P450 INHIBITOR; DIAZEPAM; DOPAMINE; DRUG METABOLIZING ENZYME; DRUG METABOLIZING ENZYME INHIBITOR; ENZYME INHIBITOR; ETILEFRINE; IMIPRAMINE; ISOPRENALINE; LEVODOPA; METIXENE; PROMETHAZINE; PROPAFENONE; QUINIDINE; RANITIDINE; SPARTEINE; SPIRONOLACTONE; TERBINAFINE; TICLOPIDINE; TRICHLORMETHIAZIDE; TRIS(2,2' BIPYRIDINE)RUTHENIUM; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMOLUMINESCENCE; ENZYME INHIBITION; EXPERIMENTAL RABBIT; GENETIC VARIABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; NONHUMAN; REACTION OPTIMIZATION;

2,2'-DIPYRIDYL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CYTOCHROME P-450 CYP2D6; ENZYME INHIBITORS; FLUORESCENT DYES; LUMINESCENCE; LUMINESCENT MEASUREMENTS; RABBITS; SPARTEINE;

EID: 79551471144     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.249     Document Type: Article

References (21)

1. Nakamura H., Omori S., Yakkyoku, 50, 2116-2128 (1999).
2. Okada K., Ariyoshi N., Yakkyoku, 54, 2757-2766 (2003).
3. Kitada K., Gekkan Yakuji, 38, 467-479 (1996).
4. Yamamoto T., Suzuki A., Kohno Y., Xenobiotica, 33, 823-839 (2003).
5. Favreau V. L., Palamanda R. J., Lin C., Nomeir A. A., Drug Metab. Dispos., 27, 436-439 (1999).
6. Orishiki M., Matsuo Y., Nishioka M., Ichikawa Y., Int. J. Biochem., 26, 751-758 (1994).
7. Narimatsu S., Arai T., Masubuchi Y., Horie T., Hosokawa M., Ueno K., Kataoka H., Yamamoto S., Ishikawa T., Cho K. A., Biol. Pharm. Bull., 24, 988-994 (2001).
8. Walsky L. R., Obach S. R., Drug Metab. Dispos., 32, 647-660 (2004).
9. Ishizaki T., Eichelbaum M., Hourai Y., Hashimoto K., Chiba K., Dengler J. H., Br. J. Clin. Pharmacol., 23, 482-485 (1987).
10. Uchikura K., Kirisawa M., Anal. Sci., 7, 803-804 (1991).
11. Martínez C., Albet C., Agúndez A. G. J., Herrero E., Carrillo A. J., Márquez M., Benítez J., Ortiz A. J., Clin. Pharmacol. Ther., 65, 369-376 (1999).
12. Iqbal T., Karyekar S. C., Kinjo M., Ngan C. G., Dowling C. T., J. Chromatogr. B, 799, 337-341 (2004).
13. Osikowska-Evers A. B., Eichelbaum M., Life Sci., 38, 1775-1782 (1986).
14. Brenner E. D., Collins C. J., Hande R. K., Cancer Chemother. Pharmacol., 18, 219-222 (1986).
15. Uchikura K., Kirisawa M., Chromatography, 13, 257-258 (1992).
16. Vickers E. M. A., Sinclair R. J., Zollinger M., Heitz F., Glänzel U., Johanson L., Fisher V., Drug Metab. Dispos., 27, 1029-1038 (1999).
17. Turpeinin M., Nieminen R., Juntunen T., Taavitsainen P., Raunio H., Pelkonen O., Drug Metab. Dispos., 32, 626-631 (2004).
18. Yamamoto T., Suzuki A., Kohno Y., Xenobiotica, 34, 87-101 (2004).
19. Hamelin A. B., Bouayad A., Drolet B., Gravel A., Turgeon J., Drug Metab. Dispos., 26, 536-539 (1998).
20. Niwa T., Shiraga T., Ishii I., Kagayama A., Takagi A., Biol. Pharm. Bull., 28, 1711-1716 (2005).
21. Lewis F. V. D., Modi S., Dickins M., Drug Metab. Rev., 34, 69-82 (2002).