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Volumn 879, Issue 5-6, 2011, Pages 449-456
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Determination of sulphasalazine and its main metabolite sulphapyridine and 5-aminosalicylic acid in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study
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Author keywords
5 Aminosalicylic acid; LC MS MS; Pharmacokinetics; Sulphapyridine; Sulphasalazine
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Indexed keywords
5-AMINOSALICYLIC ACID;
AMMONIUM ACETATE;
FREEZE/THAW CYCLES;
GRADIENT ELUTION;
HUMAN PLASMAS;
INTERNAL STANDARDS;
ION ELECTROSPRAY IONIZATION;
LC-ESI-MS/MS;
LC-MS/MS;
LINEAR RESPONSE FUNCTIONS;
LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY;
LONG TERM;
LOWER LIMIT OF QUANTITATIONS;
MOBILE PHASE;
MONITORING MODE;
ORAL DOSE;
PHARMACOKINETIC STUDIES;
PHENYL COLUMNS;
PROTEIN PRECIPITATION PROCESS;
RUNTIMES;
SIMULTANEOUS DETERMINATIONS;
STABILITY STUDY;
SULPHAPYRIDINE;
SULPHASALAZINE;
AMMONIUM COMPOUNDS;
CHROMATOGRAPHY;
FORMIC ACID;
IONIZATION;
LIQUIDS;
MASS SPECTROMETRY;
METABOLISM;
METABOLITES;
METHANOL;
PHARMACOKINETICS;
PLASMA (HUMAN);
PLASMAS;
PRECIPITATION (CHEMICAL);
VOLATILE FATTY ACIDS;
ELECTROSPRAY IONIZATION;
MESALAZINE;
SALAZOSULFAPYRIDINE;
SULFAPYRIDINE;
AREA UNDER THE CURVE;
ARTICLE;
DRUG BLOOD LEVEL;
ELECTROSPRAY MASS SPECTROMETRY;
HUMAN;
HUMAN EXPERIMENT;
LIQUID CHROMATOGRAPHY;
MAXIMUM PLASMA CONCENTRATION;
NORMAL HUMAN;
PRIORITY JOURNAL;
SINGLE DRUG DOSE;
TANDEM MASS SPECTROMETRY;
TIME TO MAXIMUM PLASMA CONCENTRATION;
CHROMATOGRAPHY, LIQUID;
DIMENHYDRINATE;
DRUG STABILITY;
HUMANS;
LINEAR MODELS;
MESALAMINE;
REPRODUCIBILITY OF RESULTS;
SENSITIVITY AND SPECIFICITY;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
SULFAPYRIDINE;
SULFASALAZINE;
TANDEM MASS SPECTROMETRY;
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EID: 79451470481
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2010.12.034 Document Type: Article |
Times cited : (55)
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References (9)
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