A liquid chromatographic-tandem mass spectrometric method for the determination of YM466, a novel Factor Xa inhibitor, in rat plasma

Journal of Pharmaceutical and Biomedical Analysis

Volumn 36, Issue 4, 2004, Pages 883-887

  Mano, Yuji ^a   Usui, Takashi ^a   Kamimura, Hidetaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Factor Xa inhibitor; LC MS MS; Plasma; Rat; Validation; YM466

Indexed keywords

[N [4 [(1 ACETIMIDOYL 4 PIPERIDYL)OXY]PHENYL]N[(7 AMIDINO 2 NAPHTYL)METHYL]SULFAMOYL]ACETIC ACID; BLOOD CLOTTING FACTOR 10A INHIBITOR; UNCLASSIFIED DRUG; YM 466;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALS; ANTITHROMBIN III; CHROMATOGRAPHY, LIQUID; MALE; MASS SPECTROMETRY; NAPHTHALENES; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; SERINE PROTEINASE INHIBITORS;

EID: 7944225862     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2004.08.015     Document Type: Article

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