Pharyngeal lavage Lymphocytosis in patients with obstructive sleep apnea: A preliminary observation

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Hauber, Hans Peter ^a   Rüller, Stefan ^a   Müller, Ernst ^a   Hansen, Eike ^a   Zabel, Peter ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTODIAGNOSIS; DISEASE SEVERITY; FEASIBILITY STUDY; FEMALE; HUMAN; HUMAN CELL; INFLAMMATORY CELL; LAVAGE; LYMPHOCYTE COUNT; LYMPHOCYTOSIS; MACROPHAGE; MALE; NON INVASIVE MEASUREMENT; PHARYNGEAL LAVAGE; RESPIRATORY TRACT INFLAMMATION; SLEEP APNEA SYNDROME; SNORING; UPPER RESPIRATORY TRACT; CASE CONTROL STUDY; CELL COUNT; EVALUATION; INFLAMMATION; LYMPHOCYTE; METHODOLOGY; NEUTROPHIL; PATHOLOGY; PHARYNX;

CASE-CONTROL STUDIES; CELL COUNT; FEASIBILITY STUDIES; HUMANS; INFLAMMATION; LYMPHOCYTES; LYMPHOCYTOSIS; NEUTROPHILS; PHARYNX; SLEEP APNEA, OBSTRUCTIVE; THERAPEUTIC IRRIGATION;

EID: 79251625691     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016277     Document Type: Article

References (15)

1. Young T, Shahar E, Nieto FJ, Redline S, Newman AB, et al. (2002) Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med 162(8): 893-900.
2. Gami AS, Pressman G, Caples SM, Kanagala R, Gard JJ, et al. (2004) Association of atrial fibrillation an obstructive sleep apnea. Circulation 110(4): 364-367.
3. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, et al. (2000) Association of sleep-disordered breathing, sleep apnea, and hypertension in a large communitybased study. Sleep Heart Health Study. J Am Med Assoc 283(14): 1829-1836.
4. Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, et al. (2001) Sleepdisordered breathing and cardiovascular disease: corss-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med 163(1): 19-25.
5. Kato M, Roberts-Thomson P, Phillips BG, Haynes WG, Winnicki M, et al. (2000) Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 102(21): 2607-2610.
6. Ohga E, Nagase T, Tomita T, Teramoto S, Matuse T, et al. (1999) Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome. J Appl Physiol 87(1): 10-14.
7. Sekosan M, Zakkar M, Wenig BL, Olopade CO, Rubinstein I (1996) Inflammation in the uvula mucosa of patients with obstructive sleep apnea. Laryngoscope 106(8): 1018-1020.
8. Rubinstein I (1995) Nasal inflammation in patients with obstructive sleep apnea. Laryngoscope 105(2): 175-177.
9. Hauber HP, Rüller S, Müller E, Zabel P (2009) Comparison of differential cell counts in pharyngeal lavage from patients with obstructive sleep apnea and from healthy control persons. Atemw Lungenkrkh 35(9): 373-378 [German].
10. Sabato R, Guido P, Salerno FG, Resta O, Spanevello A, et al. (2006) Airway inflammation in patients affected by obstructive sleep apnea. Monaldi Arch Chest Dis 65(2): 102-105.
11. Almendros I, Carreras A, Ramirez J, Montserrat JM, Navajas D, et al. (2008) Upper airway collapse and reopening induce inflammation in a sleep apnoea model. Eur Respir J 32(2): 399-404.
12. Young T, Palta M, Dempsey J, Skatrud J, Weber S, et al. (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328(17): 1230-1235.
13. Prause W, Saletu B, Anderer P, Gratzhofer E, Freidl M, et al. (2006) Sleep laboratory investigation of somatoform pain disorder assoiated with insomnia: increased incidence of periodic limb movements [German]. J Neurol Neurochir Psychiatr 7: 43-48.
14. Fridberg D (1999) Heavy snorer's disease: a progressive local neuropathy. Acta Otolaryngol 119: 925-933.
15. Boyd JH, Petrof BJ, Hamid Q, Fraser R, Kimoff RJ (2004) Upper airway muscle inflammation and denervation changes in obstructive sleep apnea. Am J Respir Crit Care Med 170(5): 541-546.