Beneficial effects of early (but not late) intervention of heme oxygenase-1 on bleomycin-induced pulmonary fibrosis in mice

Respiratory Physiology and Neurobiology

Volumn 175, Issue 2, 2011, Pages 239-246

  Jin, Chengzhen ^a   Zhou, Dan ^a   Lv, Fuzhen ^a  

^a THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Early intervention; Fibrogenesis; Heme oxygenase 1; Oxidative stress; Pulmonary fibrosis

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; BLEOMYCIN; GLUTATHIONE; HEME OXYGENASE 1; HEMIN; HYDROXYPROLINE; LACTATE DEHYDROGENASE; MESOPORPHYRIN; PHOSPHATE BUFFERED SALINE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; EARLY INTERVENTION; ENZYME ACTIVITY; FEMALE; LUNG FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BLEOMYCIN; GLUTATHIONE; HEME OXYGENASE-1; HEMIN; HYDROXYPROLINE; LACTATE DEHYDROGENASES; LUNG; MALE; MALONDIALDEHYDE; METALLOPORPHYRINS; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PULMONARY FIBROSIS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79251623021     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2010.11.010     Document Type: Article

References (32)

1. Appleton S.D., Chretien M.L., McLaughlin B.E., Vreman H.J., Stevenson D.K., Brien J.F., Nakatsu K., Maurice D.H., Marks G.S. Selective inhibition of hemeoxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations. Drug Metab. Dispos. 1999, 27:1214-1219.
2. Atzori L., Chua F., Dunsmore S.E., Willis D., Barbarisi M., McAnulty R.J., Laurent G.J. Attenuation of bleomycin induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol. Thorax 2004, 59:217-223.
3. Balla G., Jacob H.S., Balla J., Rosenberg M., Nath K., Apple F., Eaton J.W., Vercellotti G.M. Ferritin: a cytoprotective antioxidant strategem of endothelium. J. Biol. Chem. 1992, 267:18148-18153.
4. Chen Y.-S., Zhu X.-X., Zhao X.-Y., Xing H.-Y., Li Y.-G. Hemin, a heme oxygenase-1 inducer, improves aortic endothelial dysfunction in insulin resistant rats. Chin. Med. J. 2008, 121:241-247.
5. Christou H., Morita T., Hsieh C.M., Koike H., Arkonac B., Perrella M.A., Kourembanas S. Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ. Res. 2000, 86:1224-1229.
6. Cooper J.A. Pulmonary Fibrosis. Pathways are slowly coming into light. Am. J. Respir. Cell Mol. Biol. 2000, 22:520-523.
7. Dennery P.A., Lee C.S., Ford B.S., Weng Y.H., Yang G., Rodgers P.A. Developmental expression of heme oxygenase in the rat lung. Pediatr. Res. 2003, 53:42-47.
8. Dennery P.A., Spitz D.R., Yang G., Tatarov A., Lee C.S., Shegog M.L., Poss K.D. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. J. Clin. Invest. 1998, 101:1001-1011.
9. Drakopanagiotakis F., Xifteri A., Polychronopoulos V., Bouros D. Apoptosis in lung injury and fibrosis. Eur. Respir. J. 2008, 32:1631-1638.
10. Fredenburgh L., Perrella M., Mitsialis S. The role of heme oxygenase-1 in pulmonary disease. Am. J. Respir. Cell Mol. Biol. 2007, 36:158-165.
11. Han Y., Qin J., Yang Z.-X., Chang X.-Z., Du J.-B. Influence of heme oxygenase/carbon monoxide system on γ-aminobutyric acid B receptor subunits in hippocampus of rats with febrile seizures. Chin. J. Contemp. Pediatr. 2005, 7:705-707.
12. Johnston C.J., Williams J.P., Okunieff P., Finkelstein J.N. Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families. Radiat. Res. 2002, 157:256-265.
13. King T.E., Safrin S., Starko K.M., Brown K.K., Noble P.W., Raghu G., Schwartz D.A. Analyses of efficacy end points in a controlled trial of interferon-γ1b for idiopathic pulmonary fibrosis. Chest 2005, 127:171-177.
14. Kinnula V.L., Fattman C.L., Tan R.J., Oury T.D. Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy. Am. J. Respir. Crit. Care Med. 2005, 172:417-422.
15. Liu R., Li C.G., Liang X., Hai C.X. Changes of hydroxyproline and oxidative stress indices in bleomycin induced pulmonary fibrosis in rats. J. Fourth Mil. Med. Univ. 2004, 25:2202-2204. (in Chinese).
16. Maher T.M., Wells A.U., Laurent G.J. Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?. Eur. Respir. J. 2007, 30:835-839.
17. McAllister S.C., Hansen S.G., Ruhl R.A., Raggo C.M., DeFilippis V.R., Greenspan D., Fruh K., Moses A.V. Kaposi sarcoma-associated herpes virus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells. Blood 2004, 103:3465-3473.
18. Noble P. Presentation at American Thoracic Society Conference. San Diego, CA 2009.
19. Otterbein L.E. The evolution of carbon monoxide into medicine. Respir. Care 2009, 54:925-932.
20. Otterbein L.E., Choi A.M. Heme oxygenase: colors of defense against cellular stress. Am. J. Physiol. Lung Cell. Mol. Physiol. 2000, 279:L1029-L1037.
21. Poss K.D., Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:10919-10924.
22. Rosenbloom J., Castro S.V., Jimenez S.A. Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies. Ann. Intern. Med. 2010, 152:159-166.
23. Ryter S.W., Otterbein L.E., Morse D., Choi A.M. Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Mol. Cell. Biochem. 2002, 234-235:249-263.
24. Slebos D.J., Ryter S.W., Choi A.M. Heme oxygenase-1 and carbon monoxide in pulmonary medicine. Respir. Res. 2003, 4:7.
25. Strieter R.M., Gomperts B.N., Keane M.P. The role of CXC chemokines in pulmonary fibrosis. J. Clin. Invest. 2007, 117:549-556.
26. Suliman H.B., Carraway M.S., Ali A.S., Reynolds C.M., Welty-Wolf K.E., Piantadosi C.A. The CO/HO system reverses inhibition of mitochrondrial biogenesis and prevents murine doxorubicin cardiomyopathy. J. Clin. Invest. 2007, 117:3730-3741.
27. Sun J.-L., Shao J., Li Y.-Z., Yu S.-C., Xia Z.-W. Role of heme oxygenase-1 in protection against airway inflammation. J. Clin. Pediatr. 2006, 24:9-12.
28. Suttner D.M., Dennery P.A. Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J. 1999, 13:1800-1809.
29. Tsuburai T., Suzuki M., Nagashima Y., Suzuki S., Inoue S., Hasiba T., Ueda A., Ikehara K., Matsuse T., Ishigatsubo Y. Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lung prevents bleomycin-induced pulmonary fibrosis via a Fas-Fas ligand independent pathway. Hum. Gene Ther. 2002, 13:1945-1960.
30. Wang H.D., Yamaya M., Okinaga S., Jia Y.X., Kamanaka M., Takahashi H., Guo L.Y., Ohrui T., Sasaki H. Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats. Am. J. Respir. Crit. Care Med. 2002, 165:406-411.
31. Yachie A., Niida Y., Wada T., Igarashi N., Kaneda H., Toma T., Ohta K., Kasahara Y., Koizumi S. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J. Clin. Invest. 1999, 103:129-135.
32. Zhou Z., Song R., Fattman C.L., Greenhill S., Alber S., Oury T.D., Choi A.M., Morse D. Carbon monoxide suppresses bleomycin-induced lung fibrosis. Am. J. Pathol. 2005, 166:27-37.