Triazole incorporated pyridazinones as a new class of antihypertensive agents: Design, synthesis and in vivo screening

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 3, 2011, Pages 1023-1026

  Siddiqui, Anees A ^a   Mishra, Ravinesh ^a   Shaharyar, Mohammad ^a   Husain, Asif ^a   Rashid, Mohd ^a   Pal, Palash ^b  

^a HAMDARD UNIVERSITY   (India)

^b M S UNIVERSITY OF BARODA   (India)

Author keywords

1,2,4 Triazole; Antihypertensive activity; Non invasive method; Pyridazinone

Indexed keywords

6 (4 ETHYLPHENYL) 2 [4 (4 CHLOROPHENYL) 5 THIOXO 4,5 DIHYDRO 1H 1,2,4 TRIAZOL 3 YL] 4,5 DIHYDROPYRIDAZIN 3(2H) ONE; 6 (4 METHOXYPHENYL) 2 [4 (4 METHYLPHENYL) 5 THIOXO 4,5 DIHYDRO 1H 1,2,4 TRIAZOL 3 YL] 4,5 DIHYDROPYRIDAZIN 3(2H) ONE; 6 (4 METHYLPHENYL) 2 [4 (4 CHLOROPHENYL) 5 THIOXO 4,5 DIHYDRO 1H 1,2,4 TRIAZOL 3 YL] 4,5 DIHYDROPYRIDAZIN 3(2H) ONE; ANTIHYPERTENSIVE AGENT; HYDRALAZINE; PROPRANOLOL; PYRIDAZINONE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE MEASUREMENT; CHEMICAL REACTION; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HYPERTENSION; IN VIVO STUDY; MEAN ARTERIAL PRESSURE; NON INVASIVE PROCEDURE; NONHUMAN; RAT; REACTION ANALYSIS;

ANIMALS; ANTIHYPERTENSIVE AGENTS; DRUG DESIGN; PYRIDAZINES; RATS; TRIAZOLES;

EID: 79251621250     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.028     Document Type: Article

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