Effects of turnera ulmifolia (Linn.) leaves on blood glucose level in normal and alloxan-induced diabetic rats

Iranian Journal of Pharmacology and Therapeutics

Volumn 8, Issue 2, 2009, Pages 77-81

  Prabu, D ^a   Nappinnai, M ^a   Ponnudurai, K ^b   Thirugnanasambanthan, A ^c   Srinivasan, S ^d   Ramvikas, M ^a  

^a C L BAID METHA COLLEGE OF PHARMACY   (India)

^b Nandini Nagar Mahavidyalaya College of Pharmacy   (India)

^c A Constituent Unit of KLE Academy of Higher Education Research   (India)

^d MADRAS CHRISTIAN COLLEGE   (India)

Author keywords

Alloxan induced diabetes; Antihyperglycemic; Euglycemic; Rats; Turnera ulmifolia

Indexed keywords

ALLOXAN; ANTIDIABETIC AGENT; GLIBENCLAMIDE; GLUCOSE; GLYCOGEN; METHANOL; PLANT EXTRACT; TURNERA ULMIFOLIA EXTRACT; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANGIOSPERM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DOSE COMPARISON; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; GLYCOGEN LIVER LEVEL; MALE; NONHUMAN; PLANT LEAF; RAT; TURNERA ULMIFOLIA;

EID: 79251616134     PISSN: 17352657     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. King H, Aubert RE, Herman WH. Global burden of diabetes 1995-2025 prevalence, numerical estimates and projections. Diabetes Care 1998; 21:1414-31.
2. Boyle JP, Honeycutt AA, Narayan KM, Hoerger TJ, Geiss LS, Chen H, Thompson TJ. Projection of diabetes burden through2050: impact of changing demography and disease prevalence in the US. Diabetes Care 2001; 24:1936-40.
3. The Wealth of India - A dictionary of Indian raw materials and industrial products. 1959. CSIR, New Delhi, India. Vol-10, 314-5.
4. Halliwell B. Free radicals, anti-oxidant and Human Disease: Curiosity, cause or consequence. Lancet 1995; 344:721-4.
5. Havsteen B. Flavonoids, a class of natural products of High pharmacological potency. Biochem Pharm. 1983; 32:1141-8.
6. Kallappa MH. Fatty acids in seed oil from Turnera ulmifolia. Phytochemistry 1993; 34:1363-5.
7. Nascimento MA, Silva AK, Franca LCB, Quignard ELJ, Lopez JA, Almeida MG. Turnera ulmifolia L (Turneraceae): Preliminary study of its antioxidant activity. J Ethnopharmacol 2006; 97:1387-91.
8. Galvez J, Souza Gracioso JD, Camuesco D, Galvez J, Vilegas W, Souza Brito ARM, Zarzuelo A. Intestinal anti-inflammatory activity of a lyophilized infusion of Turnera ulmifolia in TNBS rat colitis. Fitoterapia 2006; 77:515-20.
9. Antonio MA, Souza Brito ARM. Oral anti-inflammatory and anti-ulcerogenic activities of hydroalcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae). J Ethnopharmacol 1998; 61:215-28.
10. Kokate CK, Purohith AP, Gokhale SB. Pharmacognosy, 1990. Nirali Prakashan, Pune 120.
11. Tunali, S., Yanardag, R. Effect of Vanadyl sulfate on the status of lipid parameters and on stomach and spleen tissue of streptozotocin-induced diabetic rats. Pharmacol Res 2006; 53:271-7.
12. Reshmic R, Fatima A, Sinilal B, and Latha MS. Anti-diabetic effect of a herbal drug in alloxan-diabetic rats. Ind Drugs 2001; 38:319-22.
13. Dash GK, Patro CP, Maiti AK. A study on the anti-hyperglycemic effect of Premna corymbosa Rotti. Roots. J Nat Remd 2005; 5:31-4.
14. Seifter S, Dayton S, Movic B, Mutwzer E. The estimation of glycogen with the anthrone reagent. Arch Biochem 1985; 25:191-201.
15. Oliver-Bever B. Medicinal Plants in Tropical West Africa. 1986. Cambridge University Press, London. 245-67.
16. Kameswara Rao B, Kesavulu MM, Giri R, Appa Rao CH. Antidiabetic and hypolipidemic effects of Momordica cymbalaria Hook fruit powder in Alloxan diabetic rats. J Ethnopharmacol 1999; 67:103-9.
17. Chakravarthy BK, Gupta S, Gambir SS, Gode KD. Pancreatic beta cell regeneration. A novel antidiabetic mechanism of Pterocarpus marsupium Roxb. Ind J Pharmacol 1980; 12:123-7.
18. Manickam M, Ramanathan M, Farboodinay Jahromi MA, Chansouria JPN, Ray AB. Antihyperglycemic activity of phenolics from Pterocarpus marsupium. J Nat Prod 1997; 60:609-60.
19. Rerup CC. Drugs producing diabetes through damage of insulin secreting cells. Pharmacol Rev 1970; 22:485-520.
20. Yallow RS, Black H, Villazan M, Berson SA. Comparison of plasma insulin levels following administration of tolbutamide and glucose. Diabetes 1960; 9:356-62.
21. Grodsky GM, Epstein GH, Fanska R, Karam JH. Pancreatic action of sulphonylureas. Fed Proceed 1971; 36: 2719-28.
22. Vats V, Yadav SP, Grover JK. Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. J Ethnopharmacol 2004; 90 155-60.
23. Whittonm PD, Hems DA. Glycogen synthesis in the perfused liver of streptozotocin-diabetic rats. Biochem J 1975; 150:153-65.
24. Golden S, Wals PA, Okajima F. Glycogen synthesis by hepatocytes from diabetic rats. Biochem J 1979; 182:727-34.
25. Weber G, Lea MA, Fisher EA. Regulatory pattern of liver carbohydrate metabolizing enzymes; insulin as an inducer of key glycolytic enzymes. Enz Biol Clin 1966; 7:11-24.
26. Steiner DF, King J. Induced synthesis of hepatic uridine diphosphate glucose glycogen glycosyltransferase after administration of insulin to alloxan diabetic rats. J Biol.Chem 1964; 239:1292-8.
27. Hikino H, Kobayashi M, Suzuki Y, Konno C. Mechanism of hypoglycemic activity of aconitan A, a glycan from Aconitum carmichaeli roots. J Ethnopharmacol 1989; 25:295-304.