The Hag-protease-II is a fibrin(ogen)ase from Hippasa agelenoides spider venom gland extract: Purification, characterization and its role in hemostasis

Toxicon

Volumn 57, Issue 2, 2011, Pages 248-258

  Devaraja, S ^a,b   Girish, K S ^a   Gowtham, Y N J ^a   Kemparaju, K ^a  

^a UNIVERSITY OF MYSORE   (India)

^b TUMKUR UNIVERSITY   (India)

Author keywords

Fibrino(geno)lytic enzyme; Hag protease II; Hippasa agelenoides; Platelet aggregation; Serine protease; Spider venom

Indexed keywords

1,10 PHENANTHROLINE; BLOOD CLOTTING FACTOR 10; CASEIN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; EDETIC ACID; EGTAZIC ACID; FIBRIN; FIBRINOGEN; FIBRONECTIN; GELATIN; HAG PROTEASE II; INDOLEACETIC ACID; SPIDER VENOM; THROMBIN; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA CHAIN; BLEEDING; CONTROLLED STUDY; EDEMA; FOOT PAD; HEMOSTASIS; HUMAN; HUMAN CELL; ION EXCHANGE CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; MOUSE; MYOTOXICITY; NONHUMAN; POISONOUS SPIDER; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PURIFICATION; THROMBOCYTE AGGREGATION; TOXICITY; TOXICITY TESTING;

ANIMALS; BLOOD COAGULATION; FEMALE; FIBRINOGEN; HEMOSTASIS; HUMANS; PLATELET AGGREGATION; SERINE ENDOPEPTIDASES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPIDER VENOMS; SPIDERS;

ARANEAE; HIPPASA; LONCHOCARPUS GLAUCIFOLIUS;

EID: 79251602212     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2010.11.018     Document Type: Article

References (40)

1. Ardlie N.G., Han P. Enzymatic basis for platelet aggregation and release: the significance of the "platelet atmosphere" and the relationship between platelet function and blood coagulation. J. Haematol. 1974, 26:331-356.
2. Born G.V.R. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962, 194:27-29.
3. Chakrabarty D., Kausiki D., Antony G., Debasish B. Hemorrhagic protein of Russell's viper venom with fibrinolytic and esterolytic activities. Toxicon 1999, 38:1475-1490.
4. Cunha R.B., Barbaro K.C., Muramatsu D., Portaro F.C.V., Fontes W., de Souza M.V. Purification and characterization of Loxnecrogin a dermonecrotic toxin from Loxosceles gaucho Brown spider venom. J. Protein Chem. 2003, 22:135-146.
5. da Silvera R.B., Filho J.F.S., Mangili O.C., Veiga S.S., Gremski W., Nader H.B., Dietrich C.P. Identification of proteases in extract of venom glands from brown spiders. Toxicon 2002, 40:815-822.
6. da Silveira R.B., Pigozzo R.B., Chaim O.M., Appel M.H., Dreyfuss J.L., Toma L., Mangili O.C., Gremski W., Dietrich C.D., Nadu H.B., Viega S.S. Molecular cloning and functional characterization of two isoforms of dermonecrotic toxin from Loxosceles intermedia (Brown spider) venom gland. Biochimie 2006, 88:1241-1253.
7. da Silveira R.B., Wille A.C.M., Chaim O.M., Appel M.H., Silva D.T., Franco C.R.C., Toma L., Mangili O.C., Gremski W.C.P., Dietrich Nader H.B., Veiga S.S. Identification, cloning, expression and functional characterization of and astacin-like metallporotese toxin from Loxosceles intermedia (Brown spider) venom. Biochem. J. 2007, 406:355-363.
8. Devaraja S., Nagaraju S., Mahadeshwara sawmy Y.H., Girish K.S., Kemparaju K. A low molecular weight serine protease: purification and characterization from Hippasa agelenoides (Funnel web) spider venom gland extract. Toxicon 2008, 52:130-138.
9. Devaraja S., Girish K.S., Devaraj V.R., Kemparaju K. Factor Xa-like and fibrin(ogen)olytic activities of a serine protease from Hippasa agelenoides spider venom gland extract. J. Thromb. Thrombolysis 2010, 29:119-126.
10. Denson K.W.E. Coagulation and anticoagulant actions of snake venoms. Toxicon 1969, 7:5-11.
11. Gutierrez J.M., Arce V., Brenes F., Chaves F. Changes in myofibrillar components after skeletal muscle necrosis induced by a myotoxin isolated from the venom of the snake Bothrops aspe. J. Exp. Mol. Pathol. 1990, 52:25-37.
12. Jackson C.M. Factor X. Prop Hemost. Thromb. 1984, 7:55-109.
13. Jing Z., Rong P.J.H., Ying L., Dong F.L., Rong Q.H. Eisenia fetida Protease-III-1 functions in both Fibrinolysis and Fibrogenesis. J. Biomed. Biotechnol. 2007, 10:1155-1165.
14. Kini R.M., Morita T., Rosing J. Classification and nomenclature of prothrombin activators isolated from snake venoms. Thromb. Haemost 2001, 86:710-711.
15. Kondo H., Kondo S., Itezawa H., Murata R., Ohasaka A. A study on the quantitative method from determination of hemorrhagic activity of Habu snake venom. Jpn. J. Med. Sci. Biol. 1969, 13:43-51.
16. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
17. Leach B.S., Collawn J.F., Fish W.W. Behavior of glycopolypeptides with empirical molecular weight estimation methods. 1. In sodium dodecyl sulfate. Biochemistry 1980, 9:5734-5741.
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin-phenol reagent. J. Biol. Chem. 1951, 193:265-275.
19. Manjunatha Kini R. Serine proteases affecting blood coagulation and Fibrinolysis from snake venoms. Pathophysiol Haemos Thromb. 2005, 34:200-204.
20. Morita T., Iwanaga S. purification and properties of prothrombin activator from the venom of Echis carinatus. J. Biochem. (Tokya) 1978, 83:559-570.
21. Nagaraju S., Mahadeshwara swamy Y.H., Girish K.S., Kemparaju K. Venom from spiders of the genus Hippasa: biochemical and pharmacological studies. Comp. Biochem. Physiol. 2006, 144:1-9.
22. Nagaraju S., Girish K.S., Fox J.W., Kemparaju K. 'Partitagin' a hemorrhagic metalloprotease from Hippasa partita spider venom: role in tissue necrosis. Biochimie 2007, 89:1322-1331.
23. Ouyang C., Teng C.M. Fibrinogenolytic enzymes of Trimeresurus mucrosquamatus venom. Biochim. Biophys. Acta 1976, 420:298-308.
24. Platnick N.I. The World Spider Catalog, Version 6.0 2005, American Museum of Natural History.
25. Persson E.P., Hogg J., Stenflo J. Effects of ca2+ binding on the protease module of factor Xa and its interaction with factor Va. Evidence for two Gla-independent Ca(2+) binding sites in factor Xa. J. Biol. Chem. 1993, 268:22531-22539.
26. Quick A.J. The prothrombin in hemophilia and obstructive jaundice. J. Biol. Chem. 1935, 107:73-85.
27. Rash L.D., Hodgson W.C. Pharmacology and biochemistry of spider venoms. Toxicon 2002, 40:225-254.
28. da Silveira Rafael, B., dos Santos Filho Jose, F., Mangili Oldemir, C., Veiga Silvio, S., Waldemiro Gremski, Helena B., Nader, von Dietrich Carl, P. Identification of proteases in the extract of venom glands from brown spiders. Toxicon 2002, 40:815-822.
29. Rajesh R., Raghavendra Gowda C.D., Nataraju A., Dhananjaya B.L., Vishwanath B.S. Procoagulant activity of Calotropis gigantea latex associated with fibrin(ogen)olytic activity. Toxicon 2005, 46:84-92.
30. Reis C.V., Fernanda C.V., Portaro Sania, A., Andrade Marcio, F., Beatriz L.F., Claudio A.M., Sampaio Antonio, C.M., Camargo Ana, M., Chudzinski T. A Prothrombin activator serine protease from the Lonoma oblique caterpillar venom (Lopap) biochemical characterization. Thromb. Res. 2001, 102:427-436.
31. Siliwal M., Molur Sanjay, Biswas B.K. Indian spiders (Arachnida: araneae): Updated checklist 2005. Zoos' Print Journal 2005, 20(10):1999-2049.
32. Swenson S., Markland F.S. Snake venom fibrin(ogen)olytic enzymes. Toxicon 2005, 45:1021-1103.
33. Satake M., Murata Y., Suzuki T. Studies on snake venoms XIII Chromatographic separation and properties of three proteinases from Agkistrodon halys blomhoffii venom. J. Biochem. 1963, 53:483-497.
34. Tikader B.K. Hand Book of Indian Spiders 1985, Zoological survey of India, Calcutta.
35. Tikader B.K., Malhotra M.S. Lycosidae (wolf spiders). Fauna India (Araneae) 1980, 1:248-447.
36. Vishwanath B.S., Kini R.M., Gowda T.V. Characterization of three edematic inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid. Toxicon 1987, 25:501-515.
37. Veiga S.S., da Sliveria R.R., Dreyfuss J.L., Haoach J., Pereira A.M., Mangili O.C., Gremski W. Identification of high molecular weight serine proteases in Loxosceles intermedia (Brown spider) venom. Toxicon 2000, 38:825-839.
38. Veiga S.S., Feitosa L., Santos V.L.P., de Souza G.A., Ribeiro A.S., Mangili O.C., Porcionatto M.A., Nada H.B., Dietrich C.P., Brentani R.R., Gremski W. Effect of Loxsceles intermedia (Brown spider) venom on basement membrane structures. Histochemical Journal 2000, 32:397-408.
39. Young A.R., Pincus S.J. Comparison of enzymatic activity from three species of necrotizing arachnids in Australia: Loxosceles rufescens, Badumna insignis and Lampona cylindrata. Toxicon 2001, 39:391-400.
40. Zanetti V.C., da Silveira R.B., Dreyfuss J.L., Haoach J., Mangili O.C., Veiga S.S., Gremski W. Morphological and biochemical evidence of blood vessel damage and fibrinogenolysis triggered by brown spider venom. Blood Coagulation Fibrinolysis 2002, 13:135-148.