메뉴 건너뛰기




Volumn 6, Issue 1, 2011, Pages

Exploitation of herpesviral transactivation allows quantitative reporter gene-based assessment of virus entry and neutralization

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTISERUM; BETA INTERFERON; IMMUNOGLOBULIN; INTERFERON REGULATORY FACTOR 3; LUCIFERASE; MONOCLONAL ANTIBODY; PP72 IE1 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS ANTIBODY;

EID: 79251576807     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014532     Document Type: Article
Times cited : (11)

References (51)
  • 1
    • 42049088686 scopus 로고    scopus 로고
    • Severe cytomegalovirus infection in apparently immunocompetent patients: A systematic review
    • Rafailidis PI, Mourtzoukou EG, Varbobitis IC, Falagas ME (2008) Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review. Virol J 5: 47.
    • (2008) Virol J , vol.5 , pp. 47
    • Rafailidis, P.I.1    Mourtzoukou, E.G.2    Varbobitis, I.C.3    Falagas, M.E.4
  • 3
    • 0026505424 scopus 로고
    • Evaluation of a microtiter plate fluorescent-antibody assay for rapid detection of human cytomegalovirus infection
    • Boppana SB, Smith RJ, Stagno S, Britt WJ (1992) Evaluation of a microtiter plate fluorescent-antibody assay for rapid detection of human cytomegalovirus infection. J Clin Microbiol 30: 721-723.
    • (1992) J Clin Microbiol , vol.30 , pp. 721-723
    • Boppana, S.B.1    Smith, R.J.2    Stagno, S.3    Britt, W.J.4
  • 5
    • 30144443835 scopus 로고    scopus 로고
    • Congenital cytomegalovirus (CMV) infection and hearing deficit
    • Fowler KB, Boppana SB (2006) Congenital cytomegalovirus (CMV) infection and hearing deficit. J Clin Virol 35: 226-231.
    • (2006) J Clin Virol , vol.35 , pp. 226-231
    • Fowler, K.B.1    Boppana, S.B.2
  • 6
    • 0026513987 scopus 로고
    • The Outcome of Congenital Cytomegalovirus-Infection in Relation to Maternal Antibody Status
    • Fowler KB, Stagno S, Pass RF, Britt WJ, Boll TJ, et al. (1992) The Outcome of Congenital Cytomegalovirus-Infection in Relation to Maternal Antibody Status. New England Journal of Medicine 326: 663-667.
    • (1992) New England Journal of Medicine , vol.326 , pp. 663-667
    • Fowler, K.B.1    Stagno, S.2    Pass, R.F.3    Britt, W.J.4    Boll, T.J.5
  • 8
    • 0020026026 scopus 로고
    • Congenital Cytomegalovirus-Infection - the Relative Importance of Primary and Recurrent Maternal Infection
    • Stagno S, Pass RF, Dworsky ME, Henderson RE, Moore EG, et al. (1982) Congenital Cytomegalovirus-Infection - the Relative Importance of Primary and Recurrent Maternal Infection. New England Journal of Medicine 306: 945-949.
    • (1982) New England Journal of Medicine , vol.306 , pp. 945-949
    • Stagno, S.1    Pass, R.F.2    Dworsky, M.E.3    Henderson, R.E.4    Moore, E.G.5
  • 9
    • 0028227003 scopus 로고
    • Antibodies are not essential for the resolution of primary cytomegalovirus infection but limit dissemination of recurrent virus
    • Jonjic S, Pavic I, Polic B, Crnkovic I, Lucin P, et al. (1994) Antibodies are not essential for the resolution of primary cytomegalovirus infection but limit dissemination of recurrent virus. J Exp Med 179: 1713-1717.
    • (1994) J Exp Med , vol.179 , pp. 1713-1717
    • Jonjic, S.1    Pavic, I.2    Polic, B.3    Crnkovic, I.4    Lucin, P.5
  • 10
    • 0036719574 scopus 로고    scopus 로고
    • Antibodies, viruses and vaccines
    • Burton DR (2002) Antibodies, viruses and vaccines. Nature Reviews Immunology 2: 706-713.
    • (2002) Nature Reviews Immunology , vol.2 , pp. 706-713
    • Burton, D.R.1
  • 11
    • 25444434851 scopus 로고    scopus 로고
    • Passive immunization during pregnancy for congenital cytomegalovirus infection
    • Nigro G, Adler SP, La TR, Best AM (2005) Passive immunization during pregnancy for congenital cytomegalovirus infection. N Engl J Med 353: 1350-1362.
    • (2005) N Engl J Med , vol.353 , pp. 1350-1362
    • Nigro, G.1    Adler, S.P.2    la, T.R.3    Best, A.M.4
  • 12
    • 33344479421 scopus 로고    scopus 로고
    • Antiviral antibody responses: The two extremes of a wide spectrum
    • Hangartner L, Zinkernagel RM, Hengartner H (2006) Antiviral antibody responses: the two extremes of a wide spectrum. Nat Rev Immunol 6: 231-243.
    • (2006) Nat Rev Immunol , vol.6 , pp. 231-243
    • Hangartner, L.1    Zinkernagel, R.M.2    Hengartner, H.3
  • 13
    • 0031769970 scopus 로고    scopus 로고
    • Differentiation between acute primary and recurrent human cytomegalovirus infection in pregnancy, using a microneutralization assay
    • Eggers M, Metzger C, Enders G (1998) Differentiation between acute primary and recurrent human cytomegalovirus infection in pregnancy, using a microneutralization assay. J Med Virol 56: 351-358.
    • (1998) J Med Virol , vol.56 , pp. 351-358
    • Eggers, M.1    Metzger, C.2    Enders, G.3
  • 14
    • 0035122285 scopus 로고    scopus 로고
    • Use of recombinant glycoprotein antigens gB and gH for diagnosis of primary human cytomegalovirus infection during pregnancy
    • Eggers M, Radsak K, Enders G, Reschke M (2001) Use of recombinant glycoprotein antigens gB and gH for diagnosis of primary human cytomegalovirus infection during pregnancy. J Med Virol 63: 135-142.
    • (2001) J Med Virol , vol.63 , pp. 135-142
    • Eggers, M.1    Radsak, K.2    Enders, G.3    Reschke, M.4
  • 15
    • 45549103019 scopus 로고    scopus 로고
    • Human cytomegalovirus serum neutralizing antibodies block virus infection of endothelial/epithelial cells, but not fibroblasts, early during primary infection
    • Gerna G, Sarasini A, Patrone M, Percivalle E, Fiorina L, et al. (2008) Human cytomegalovirus serum neutralizing antibodies block virus infection of endothelial/epithelial cells, but not fibroblasts, early during primary infection. J Gen Virol 89: 853-865.
    • (2008) J Gen Virol , vol.89 , pp. 853-865
    • Gerna, G.1    Sarasini, A.2    Patrone, M.3    Percivalle, E.4    Fiorina, L.5
  • 16
    • 29144522907 scopus 로고    scopus 로고
    • Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism
    • Wang D, Shenk T (2005) Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism. Proc Natl Acad Sci U S A 102: 18153-18158.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18153-18158
    • Wang, D.1    Shenk, T.2
  • 17
    • 34147104047 scopus 로고    scopus 로고
    • Novel microneutralization assay for HCMV using automated data collection and analysis
    • Abai AM, Smith LR, Wloch MK (2007) Novel microneutralization assay for HCMV using automated data collection and analysis. J Immunol Methods 322: 82-93.
    • (2007) J Immunol Methods , vol.322 , pp. 82-93
    • Abai, A.M.1    Smith, L.R.2    Wloch, M.K.3
  • 18
    • 0024512823 scopus 로고
    • A rapid microneutralization assay for the measurement of neutralizing antibody reactive with human cytomegalovirus
    • Andreoni M, Faircloth M, Vugler L, Britt WJ (1989) A rapid microneutralization assay for the measurement of neutralizing antibody reactive with human cytomegalovirus. J Virol Methods 23: 157-167.
    • (1989) J Virol Methods , vol.23 , pp. 157-167
    • Andreoni, M.1    Faircloth, M.2    Vugler, L.3    Britt, W.J.4
  • 19
    • 0024452262 scopus 로고
    • A novel function of the herpes simplex virus type 1 Fc receptor: Participation in bipolar bridging of antiviral immunoglobulin G
    • Frank I, Friedman HM (1989) A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G. J Virol 63: 4479-4488.
    • (1989) J Virol , vol.63 , pp. 4479-4488
    • Frank, I.1    Friedman, H.M.2
  • 21
    • 38049107480 scopus 로고    scopus 로고
    • Human cytomegalovirus uses two distinct pathways to enter retinal pigmented epithelial cells
    • Wang D, Yu QC, Schroer J, Murphy E, Shenk T (2007) Human cytomegalovirus uses two distinct pathways to enter retinal pigmented epithelial cells. Proc Natl Acad Sci U S A 104: 20037-20042.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20037-20042
    • Wang, D.1    Yu, Q.C.2    Schroer, J.3    Murphy, E.4    Shenk, T.5
  • 23
    • 70349255946 scopus 로고    scopus 로고
    • Multifaceted evasion of the interferon response by cytomegalovirus
    • Marshall EE, Geballe AP (2009) Multifaceted evasion of the interferon response by cytomegalovirus. J Interferon Cytokine Res 29: 609-619.
    • (2009) J Interferon Cytokine Res , vol.29 , pp. 609-619
    • Marshall, E.E.1    Geballe, A.P.2
  • 24
    • 0032830315 scopus 로고    scopus 로고
    • Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3
    • Jerome KR, Fox R, Chen Z, Sears AE, Lee H, et al. (1999) Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3. J Virol 73: 8950-8957.
    • (1999) J Virol , vol.73 , pp. 8950-8957
    • Jerome, K.R.1    Fox, R.2    Chen, Z.3    Sears, A.E.4    Lee, H.5
  • 25
    • 0023258837 scopus 로고
    • Beta interferon production in primed and unprimed cells infected with human cytomegalovirus
    • Rodriguez JE, Loepfe TR, Swack NS (1987) Beta interferon production in primed and unprimed cells infected with human cytomegalovirus. Arch Virol 94: 177-189.
    • (1987) Arch Virol , vol.94 , pp. 177-189
    • Rodriguez, J.E.1    Loepfe, T.R.2    Swack, N.S.3
  • 26
    • 0001122795 scopus 로고
    • Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines
    • Diaz MO, Ziemin S, Le Beau MM, Pitha P, Smith SD, et al. (1988) Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines. Proc Natl Acad Sci U S A 85: 5259-5263.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 5259-5263
    • Diaz, M.O.1    Ziemin, S.2    le Beau, M.M.3    Pitha, P.4    Smith, S.D.5
  • 27
    • 0028991823 scopus 로고
    • Construction of a novel bovine papillomavirus vector without detectable transforming activity suitable for gene transfer
    • Ohe Y, Zhao D, Saijo N, Podack ER (1995) Construction of a novel bovine papillomavirus vector without detectable transforming activity suitable for gene transfer. Hum Gene Ther 6: 325-333.
    • (1995) Hum Gene Ther , vol.6 , pp. 325-333
    • Ohe, Y.1    Zhao, D.2    Saijo, N.3    Podack, E.R.4
  • 28
    • 0342284520 scopus 로고
    • Regulation of herpesvirus macromolecular synthesis: Sequential transition of polypeptide synthesis requires functional viral polypeptides
    • Honess RW, Roizman B (1975) Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides. Proc Natl Acad Sci U S A 72: 1276-1280.
    • (1975) Proc Natl Acad Sci U S A , vol.72 , pp. 1276-1280
    • Honess, R.W.1    Roizman, B.2
  • 29
    • 0017194432 scopus 로고
    • Herpes simplex virus gene expression in transformed cells. I. Regulation of the viral thymidine kinase gene in transformed L cells by products of superinfecting virus
    • Leiden JM, Buttyan R, Spear PG (1976) Herpes simplex virus gene expression in transformed cells. I. Regulation of the viral thymidine kinase gene in transformed L cells by products of superinfecting virus. J Virol 20: 413-424.
    • (1976) J Virol , vol.20 , pp. 413-424
    • Leiden, J.M.1    Buttyan, R.2    Spear, P.G.3
  • 30
    • 0016340777 scopus 로고
    • Expression of the viral thymidine kinase gene in herpes simplex virus-transformed L cells
    • Lin SS, Munyon W (1974) Expression of the viral thymidine kinase gene in herpes simplex virus-transformed L cells. J Virol 14: 1199-1208.
    • (1974) J Virol , vol.14 , pp. 1199-1208
    • Lin, S.S.1    Munyon, W.2
  • 31
    • 69449088474 scopus 로고    scopus 로고
    • Glycoprotein N subtypes of human cytomegalovirus induce a strain-specific antibody response during natural infection
    • Burkhardt C, Himmelein S, Britt W, Winkler T, Mach M (2009) Glycoprotein N subtypes of human cytomegalovirus induce a strain-specific antibody response during natural infection. J Gen Virol 90: 1951-1961.
    • (2009) J Gen Virol , vol.90 , pp. 1951-1961
    • Burkhardt, C.1    Himmelein, S.2    Britt, W.3    Winkler, T.4    Mach, M.5
  • 32
    • 0027398669 scopus 로고
    • Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies
    • Ohlin M, Sundqvist VA, Mach M, Wahren B, Borrebaeck CA (1993) Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies. J Virol 67: 703-710.
    • (1993) J Virol , vol.67 , pp. 703-710
    • Ohlin, M.1    Sundqvist, V.A.2    Mach, M.3    Wahren, B.4    Borrebaeck, C.A.5
  • 33
    • 0018930595 scopus 로고
    • Type-common and type-specific monoclonal antibody to herpes simplex virus type 1
    • Pereira L, Klassen T, Baringer JR (1980) Type-common and type-specific monoclonal antibody to herpes simplex virus type 1. Infect Immun 29: 724-732.
    • (1980) Infect Immun , vol.29 , pp. 724-732
    • Pereira, L.1    Klassen, T.2    Baringer, J.R.3
  • 34
    • 0034469169 scopus 로고    scopus 로고
    • Localization of a binding site for herpes simplex virus glycoprotein D on herpesvirus entry mediator C by using antireceptor monoclonal antibodies
    • Krummenacher C, Baribaud I, de Leon MP, Whitbeck JC, Lou H, et al. (2000) Localization of a binding site for herpes simplex virus glycoprotein D on herpesvirus entry mediator C by using antireceptor monoclonal antibodies. Journal of Virology 74: 10863-10872.
    • (2000) Journal of Virology , vol.74 , pp. 10863-10872
    • Krummenacher, C.1    Baribaud, I.2    de Leon, M.P.3    Whitbeck, J.C.4    Lou, H.5
  • 35
    • 0033621651 scopus 로고    scopus 로고
    • Nectin2 alpha (PRR2 alpha or HveB) and nectin2 delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D
    • Lopez M, Cocchi F, Menotti L, Avitabile E, Dubreuil P, et al. (2000) Nectin2 alpha (PRR2 alpha or HveB) and nectin2 delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D. Journal of Virology 74: 1267-1274.
    • (2000) Journal of Virology , vol.74 , pp. 1267-1274
    • Lopez, M.1    Cocchi, F.2    Menotti, L.3    Avitabile, E.4    Dubreuil, P.5
  • 36
    • 2642673606 scopus 로고    scopus 로고
    • Monoclonal antibodies to distinct sites on herpes simplex virus (HSV) glycoprotein D block HSV binding to HVEM
    • Nicola AV, de Leon MP, Xu RL, Hou WF, Whitbeck JC, et al. (1998) Monoclonal antibodies to distinct sites on herpes simplex virus (HSV) glycoprotein D block HSV binding to HVEM. Journal of Virology 72: 3595-3601.
    • (1998) Journal of Virology , vol.72 , pp. 3595-3601
    • Nicola, A.V.1    de Leon, M.P.2    Xu, R.L.3    Hou, W.F.4    Whitbeck, J.C.5
  • 37
    • 4444348501 scopus 로고    scopus 로고
    • Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes
    • Hahn G, Revello MG, Patrone M, Percivalle E, Campanini G, et al. (2004) Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes. J Virol 78: 10023-10033.
    • (2004) J Virol , vol.78 , pp. 10023-10033
    • Hahn, G.1    Revello, M.G.2    Patrone, M.3    Percivalle, E.4    Campanini, G.5
  • 38
    • 0034996845 scopus 로고    scopus 로고
    • Binding of human and animal immunoglobulins to the IgG Fc receptor induced by human cytomegalovirus
    • Antonsson A, Johansson PJ (2001) Binding of human and animal immunoglobulins to the IgG Fc receptor induced by human cytomegalovirus. J Gen Virol 82: 1137-1145.
    • (2001) J Gen Virol , vol.82 , pp. 1137-1145
    • Antonsson, A.1    Johansson, P.J.2
  • 39
    • 0036333909 scopus 로고    scopus 로고
    • Identification and expression of human cytomegalovirus transcription units coding for two distinct Fcgamma receptor homologs
    • Atalay R, Zimmermann A, Wagner M, Borst E, Benz C, et al. (2002) Identification and expression of human cytomegalovirus transcription units coding for two distinct Fcgamma receptor homologs. J Virol 76: 8596-8608.
    • (2002) J Virol , vol.76 , pp. 8596-8608
    • Atalay, R.1    Zimmermann, A.2    Wagner, M.3    Borst, E.4    Benz, C.5
  • 40
    • 0034767028 scopus 로고    scopus 로고
    • Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein
    • Lilley BN, Ploegh HL, Tirabassi RS (2001) Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein. J Virol 75: 11218-11221.
    • (2001) J Virol , vol.75 , pp. 11218-11221
    • Lilley, B.N.1    Ploegh, H.L.2    Tirabassi, R.S.3
  • 41
    • 41149107316 scopus 로고    scopus 로고
    • The human cytomegalovirus Fc receptor gp68 binds the Fc CH2-CH3 interface of immunoglobulin G
    • Sprague ER, Reinhard H, Cheung EJ, Farley AH, Trujillo RD, et al. (2008) The human cytomegalovirus Fc receptor gp68 binds the Fc CH2-CH3 interface of immunoglobulin G. J Virol 82: 3490-3499.
    • (2008) J Virol , vol.82 , pp. 3490-3499
    • Sprague, E.R.1    Reinhard, H.2    Cheung, E.J.3    Farley, A.H.4    Trujillo, R.D.5
  • 42
    • 0018569148 scopus 로고
    • Membrane proteins specified by herpes simplex viruses. V. Identification of an Fc-binding glycoprotein
    • Baucke RB, Spear PG (1979) Membrane proteins specified by herpes simplex viruses. V. Identification of an Fc-binding glycoprotein. J Virol 32: 779-789.
    • (1979) J Virol , vol.32 , pp. 779-789
    • Baucke, R.B.1    Spear, P.G.2
  • 43
    • 0023834392 scopus 로고
    • Herpes simplex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gI
    • Johnson DC, Frame MC, Ligas MW, Cross AM, Stow ND (1988) Herpes simplex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gI. J Virol 62: 1347-1354.
    • (1988) J Virol , vol.62 , pp. 1347-1354
    • Johnson, D.C.1    Frame, M.C.2    Ligas, M.W.3    Cross, A.M.4    Stow, N.D.5
  • 44
    • 0028797157 scopus 로고
    • Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B
    • Pahl HL, Baeuerle PA (1995) Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B. J Virol 69: 1480-1484.
    • (1995) J Virol , vol.69 , pp. 1480-1484
    • Pahl, H.L.1    Baeuerle, P.A.2
  • 45
    • 0029609890 scopus 로고
    • Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells
    • Hengel H, Esslinger C, Pool J, Goulmy E, Koszinowski UH (1995) Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells. J Gen Virol 76(Pt 12): 2987-2997.
    • (1995) J Gen Virol , vol.76 , Issue.PART 12 , pp. 2987-2997
    • Hengel, H.1    Esslinger, C.2    Pool, J.3    Goulmy, E.4    Koszinowski, U.H.5
  • 46
    • 0032824127 scopus 로고    scopus 로고
    • Cloning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli: A new approach for construction of HCMV mutants
    • Borst EM, Hahn G, Koszinowski UH, Messerle M (1999) Cloning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli: a new approach for construction of HCMV mutants. J Virol 73: 8320-8329.
    • (1999) J Virol , vol.73 , pp. 8320-8329
    • Borst, E.M.1    Hahn, G.2    Koszinowski, U.H.3    Messerle, M.4
  • 47
    • 41649106749 scopus 로고    scopus 로고
    • Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E
    • Sinzger C, Hahn G, Digel M, Katona R, Sampaio KL, et al. (2008) Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E. J Gen Virol 89: 359-368.
    • (2008) J Gen Virol , vol.89 , pp. 359-368
    • Sinzger, C.1    Hahn, G.2    Digel, M.3    Katona, R.4    Sampaio, K.L.5
  • 48
    • 0038678234 scopus 로고    scopus 로고
    • Murine cytomegalovirus abortively infects human dendritic cells, leading to expression and presentation of virally vectored genes
    • Wang X, Messerle M, Sapinoro R, Santos K, Hocknell PK, et al. (2003) Murine cytomegalovirus abortively infects human dendritic cells, leading to expression and presentation of virally vectored genes. J Virol 77: 7182-7192.
    • (2003) J Virol , vol.77 , pp. 7182-7192
    • Wang, X.1    Messerle, M.2    Sapinoro, R.3    Santos, K.4    Hocknell, P.K.5
  • 49
    • 0017080733 scopus 로고
    • Human cytomegalovirus: Glycoproteins associated with virions and dense bodies
    • Stinski MF (1976) Human cytomegalovirus: glycoproteins associated with virions and dense bodies. J Virol 19: 594-609.
    • (1976) J Virol , vol.19 , pp. 594-609
    • Stinski, M.F.1
  • 50
    • 54449100076 scopus 로고    scopus 로고
    • Human cytomegalovirus interferes with signal transducer and activator of transcription (STAT) 2 protein stability and tyrosine phosphorylation
    • Le VT, Trilling M, Wilborn M, Hengel H, Zimmermann A (2008) Human cytomegalovirus interferes with signal transducer and activator of transcription (STAT) 2 protein stability and tyrosine phosphorylation. J Gen Virol 89: 2416-2426.
    • (2008) J Gen Virol , vol.89 , pp. 2416-2426
    • Le, V.T.1    Trilling, M.2    Wilborn, M.3    Hengel, H.4    Zimmermann, A.5
  • 51
    • 44649160257 scopus 로고    scopus 로고
    • Mouse cytomegalovirus inhibits beta interferon (IFN-beta) gene expression and controls activation pathways of the IFN-beta enhanceosome
    • Le VT, Trilling M, Zimmermann A, Hengel H (2008) Mouse cytomegalovirus inhibits beta interferon (IFN-beta) gene expression and controls activation pathways of the IFN-beta enhanceosome. J Gen Virol 89: 1131-1141.
    • (2008) J Gen Virol , vol.89 , pp. 1131-1141
    • Le, V.T.1    Trilling, M.2    Zimmermann, A.3    Hengel, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.