Transmitter release in the neuromuscular synapse of the protein kinase C theta-deficient adult mouse

Journal of Comparative Neurology

Volumn 519, Issue 5, 2011, Pages 849-855

  Besalduch, Núria ^a   Santafé, Manel M ^a   Garcia, Neus ^a   Gonzalez, Carmen ^a   Tomás, Marta ^a   Tomás, Josep ^a   Lanuza, Maria A ^a  

^a FACULTAT DE MEDICINA I CIÈNCIES DE LA SALUT   (Spain)

Author keywords

KO mouse; NAChR; Neuromuscular junction; PKC theta; Synaptic transmission

Indexed keywords

PROTEIN KINASE C THETA;

ADULT ANIMAL; AMPLITUDE MODULATION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENDPLATE POTENTIAL; MORPHOLOGY; MOUSE; MYELIN SHEATH; NERVE FIBER; NEUROMUSCULAR SYNAPSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; SYNAPSE VESICLE; WILD TYPE;

ANIMALS; ELECTROPHYSIOLOGY; ISOENZYMES; MICE; MICE, KNOCKOUT; NERVE FIBERS; NEUROMUSCULAR JUNCTION; PRESYNAPTIC TERMINALS; PROTEIN KINASE C; SYNAPTIC TRANSMISSION; SYNAPTIC VESICLES;

EID: 79251562175     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.22551     Document Type: Article

References (21)

1. Besalduch N, Tomás M, Santafé M, Garcia N, Tomás J, Lanuza MA. 2010. Synaptic activity-related classical-PKC isoforms localization in the adult rat neuromuscular synapse. J Comp Neurol 518: 211-228.
2. Byrne JH, Kandel ER. 1996. Presynaptic facilitation revisited: state and time dependence. J Neurosci 16: 425-435.
3. 2+ channels and snare proteins in neurotransmitter release. Ann N Y Acad Sci 868: 144-159.
4. Hilgenberg L, Miles K. 1995. Developmental regulation of a protein kinase C isoform localized to the neuromuscular junction. J Cell Sci 108: 51-61.
5. Hilgenberg L, Yearwood S, Milstein S, Miles K. 1996. Neural influence on protein kinase C expression in skeletal muscle. J Neurosci 16: 4994-5003.
6. Inoue A, Akagawa K. 1993. Neuron specific expression of a membrane protein, HPC-1: tissue distribution, and cellular and subcellular localization of immunoreactivity and mRNA. Brain Res Mol Brain Res 19: 121-128.
7. Inoue A, Obata K, Akagawa K. 1992. Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1. J Biol Chem 267: 10613-10619.
8. Lanuza MA, Besalduch N, Garcia N, Sabaté M, Santafé MM, Tomás J. 2007. Plastic embedded semithin cross-sections as a tool for high-resolution immunofluorescence analisis of the neuromuscular junction molecules: specific cellular location of proteaseactivated receptor-1. J Neurosci Res 85: 748-756.
9. Lanuza MA, Besalduch N, González C, Santafé MM, Garcia N, Tomás M, Nelson PG, Tomás J. 2010. Decreased phosphorylation of delta and epsilon subunits of the acetylcholine receptor coincides with delayed postsynaptic maturation in PKC theta deficient mouse. Exp Neurol 225: 183-195.
10. Li MX, Jia M, Yang LX, Jiang H, Lanuza MA, González CM, Nelson PG. 2004. The role of the theta isoform of protein kinase C (PKC) in activity-dependent synapse elimination: evidence from the PKC theta knock-out mouse in vivo and in vitro. J Neurosci 24: 3762-3769.
11. McLachlan EM, Martin AR. 1981. Non-linear summation of end-plate potentials in the frog and mouse. J Physiol 311: 307-324.
12. Mochly-Rosen D, Gordon AS. 1998. Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J 12: 35-42.
13. Nelson PG. 2005. Activity-dependent synapse modulation and the pathogenesis of Alzheimer disease. Curr Alzheimer Res 2: 497-506.
14. Nelson PG, Lanuza MA, Jia M, Li MX, Tomás J. 2003. Phosphorylation reactions in activity-dependent synapse modification at the neuromuscular junction during development. J Neurocytol 32: 803-816.
15. Nishizuka Y. 1995. Protein kinase C and lipid signalling for sustained cellular responses. FASEB J 9: 484-496.
16. Numann R, Hauschka SD, Catterall WA, Scheuer T. 1994. Modulation of skeletal muscle sodium channels in a satellite cell line by protein kinase C. J Neurosci 14: 4226- 4236.
17. Santafé MM, Garcia N, Lanuza MA, Tomás M, Besalduch N, Tomás J. 2009. Presynaptic muscarinic receptors, calcium channels, and protein kinase C modulate the functional disconnection of weak inputs at polyinnervated neonatal neuromuscular synapses. J Neurosci Res 87: 1195-1206.
18. Sun Z, Arendt C, Ellmeier W, Schaeffer E, Sunshine M, Gandhi L, Annes J, Petrzilka D, Kupfer A, Schwartzberg P, Littman D. 2000. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature 404: 402-407.
19. Swope SL, Moss SJ, Raymond LA, Huganir RL. 1999. Regulation of ligand-gated ion channels by protein phosphorylation. Adv Second Messenger Phosphoprotein Res 33: 49-78.
20. Tanaka C, Nishizuka Y. 1994. The protein kinase C family for neuronal signaling. Annu Rev Neurosci 17: 551-567.
21. + channel required for modulation by protein kinase C. Science 254: 866-868.