In vivo characterization of renal auto-antigens involved in human auto-immune diseases: The case of membranous glomerulonephritis

Proteomics - Clinical Applications

Volumn 5, Issue 1-2, 2011, Pages 90-97

  Murtas, Corrado ^a   Bruschi, Maurizio ^b   Carnevali, Maria Luisa ^a   Petretto, Andrea ^c   Corradini, Emilia ^a   Prunotto, Marco ^b   Candiano, Giovanni ^b   Degl'Innocenti, Maria Ludovica ^b   Ghiggeri, Gian Marco ^b   Allegri, Landino ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b Laboratory on Pathophysiology of Uremia   (Italy)

^c G GASLINI INSTITUTE   (Italy)

Author keywords

Auto antigens; Auto immune diseases; Membranous Glomenalonephritis

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; IMMUNOGLOBULIN G4; IMMUNOSUPPRESSIVE AGENT; PHOSPHOLIPASE A2 RECEPTOR; STEROID; SUPEROXIDE DISMUTASE;

ANTIBODY BLOOD LEVEL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; AUTOIMMUNITY; DISEASE MARKER; HUMAN; IMMUNOGLOBULIN DEPOSITION; IN VIVO STUDY; INTERMETHOD COMPARISON; KIDNEY BIOPSY; LASER CAPTURE MICRODISSECTION; MASS SPECTROMETRY; MEMBRANOUS GLOMERULONEPHRITIS; NEPHROTIC SYNDROME; NONHUMAN; PATHOGENESIS; PODOCYTE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEOMICS; REVIEW; TWO DIMENSIONAL ELECTROPHORESIS; WESTERN BLOTTING;

ANIMALS; AUTOANTIGENS; GLOMERULONEPHRITIS, MEMBRANOUS; HUMANS; KIDNEY; PODOCYTES;

ANIMALIA; RATTUS;

EID: 79251541477     PISSN: 18628346     EISSN: 18628354     Source Type: Journal    
DOI: 10.1002/prca.201000079     Document Type: Review

References (34)

1. Bagavant, H., Fu, S. M., Pathogenesis of kidney disease in systemic lupus erythematosus. Curr. Opin. Rheumatol. 2009, 21, 489-494.
2. Heymann, W., Lund, H. Z., Hackel, D. B., The nephrotic syndrome in rats; with special reference to the progression of the glomerular lesion and to the use of nephrotoxic sera obtained from ducks. J. Lab. Clin. Med. 1952, 39, 218-224.
3. Ponticelli, C., Zucchelli, P., Imbasciati, E., Cagnoli, L. et al., Controlled trial of methylprednisolone and chlorambucil in idiopathic membranous nephropathy. N. Engl. J. Med. 1984, 310, 946-950.
4. Glassock, R. J., Diagnosis and natural course of membranous nephropathy. Semin. Nephrol. 2003, 23, 324-332.
5. Kerjaschki, D., Pathomechanisms and molecular basis of membranous glomerulopathy. Lancet 2004, 364, 1194-1196.
6. Kerjaschki, D., Horvat, R., Binder, S., Susani, M. et al., Identification of a 400-kd protein in the brush borders of human kidney tubules that is similar to gp330, the nephritogenic antigen of rat Heymann nephritis. Am. J. Pathol. 1987, 129, 183-191.
7. Kerjaschki, D., Ullrich, R., Diem, K., Pietromonaco, S. et al., Identification of a pathogenic epitope involved in initiation of Heymann nephritis. Proc. Natl. Acad. Sci. USA 1992, 89, 11179-11183.
8. Kerjaschki, D., Farquhar, M. G., The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc. Natl. Acad. Sci. USA 1982, 79, 5557-5561.
9. Couser, W. G., Steinmuller, D. R., Stilmant, M. M., Salant, D. J., Lowenstein, L. M., Experimental glomerulonephritis in the isolated perfused rat kidney. J. Clin. Invest. 1978, 62, 1275-1287.
10. Van Damme, B. J., Fleuren, G. J., Bakker, W. W., Vernier, R. L., Hoedemaeker, P. J., Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis. Lab. Invest. 1978, 38, 502-510.
11. Salant, D. J., Belok, S., Madaio, M. P., Couser, W. G., A new role for complement in experimental membranous nephropathy in rats. J. Clin. Invest. 1980, 66, 1339-1350.
12. Salant, D. J., Darby, C., Couser, W. G., Experimental membranous glomerulonephritis in rats. Quantitative studies of glomerular immune deposit formation in isolated glomeruli and whole animals. J. Clin. Invest. 1980, 66, 71-81.
13. Saito, A., Pietromonaco, S., Loo, A. K., Farquhar, M. G., Complete cloning and sequencing of rat gp330/"megalin, "a distinctive member of the low density lipoprotein receptor gene family. Proc. Natl. Acad. Sci. USA 1994, 91, 9725-9729.
14. Cybulsky, A. V., Takano, T., Papillon, J., McTavish, A. J., Complement-induced phospholipase A2 activation in experimental membranous nephropathy. Kidney Int. 2000, 57, 1052-1062.
15. Ghiggeri, G. M., Bruschi, M., Candiano, G., Rastaldi, M. P. et al., Depletion of clusterin in renal diseases causing nephrotic syndrome. Kidney Int. 2002, 62, 2184-2194.
16. Rastaldi, M. P., Candiano, G., Musante, L., Bruschi, M. et al., Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans. Kidney Int. 2006, 70, 477-485.
17. Bruschi, M., Candiano, G., Murtas, C., Prunotto, M. et al., Patients with primary membranous nephropathy lack auto-antibodies against LDL receptor, the homologue of megalin in human glomeruli. NDT Plus 2009, sfp002.
18. Ronco, P., Allegri, L., Brianti, E., Chatelet, F. et al., Antigenic targets in epimembranous glomerulonephritis. Experimental data and potential application in human pathology. Appl. Pathol. 1989, 7, 85-98.
19. Assmann, K. J., van Son, J. P., Dijkman, H. B., Koene, R. A., A nephritogenic rat monoclonal antibody to mouse aminopeptidase A. Induction of massive albuminuria after a single intravenous injection. J. Exp. Med. 1992, 175, 623-635.
20. Debiec, H., Guigonis, V., Mougenot, B., Decobert, F. et al., Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N. Engl. J. Med. 2002, 346, 2053-2060.
21. Debiec, H., Nauta, J., Coulet, F., van der Burg, M. et al., Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies. Lancet 2004, 364, 1252-1259.
22. Beck Jr, L. H., Bonegio, R. G., Lambeau, G., Beck, D. M. et al., M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N. Engl. J. Med. 2009, 361, 11-21.
23. Prunotto, M., Carnevali, M. L., Candiano, G., Murtas, C. et al., Autoimmunity in membranous nephropathy targets aldose reductase and SOD2. J. Am. Soc. Nephrol. 2010, 21, 507-519.
24. East, L., Isacke, C. M., The mannose receptor family. Biochim. Biophys. Acta 2002, 1572, 364-386.
25. Lambeau, G., Lazdunski, M., Receptors for a growing family of secreted phospholipases A2. Trends Pharmacol. Sci. 1999, 20, 162-170.
26. Son, D., Kojima, I., Inagi, R., Matsumoto, M. et al., Chronic hypoxia aggravates renal injury via suppression of Cu/Zn-SOD: a proteomic analysis. Am. J. Physiol. Renal Physiol. 2008, 294, F62-F72.
27. Williamson, J. R., Chang, K., Frangos, M., Hasan, K. S. et al., Hyperglycemic pseudohypoxia and diabetic complications. Diabetes 1993, 42, 801-813.
28. Srivastava, S., Spite, M., Trent, J. O., West, M. B. et al., Aldose reductase-catalyzed reduction of aldehyde phospholipids. J. Biol. Chem. 2004, 279, 53395-53406.
29. Barski, O. A., Papusha, V. Z., Ivanova, M. M., Rudman, D. M., Finegold, M. J., Developmental expression and function of aldehyde reductase in proximal tubules of the kidney. Am. J. Physiol. Renal Physiol. 2005, 289, F200-F207.
30. Terubayashi, H., Sato, S., Nishimura, C., Kador, P. F., Kinoshita, J. H., Localization of aldose and aldehyde reductase in the kidney. Kidney Int. 1989, 36, 843-851.
31. Youinou, P., New target antigens for anti-endothelial cell antibodies. Immunobiology 2005, 210, 789-797.
32. Servettaz, A., Guilpain, P., Tamas, N., Kaveri, S. V. et al., Natural anti-endothelial cell antibodies. Autoimmun. Rev. 2008, 7, 426-430.
33. Candiano, G., Bruschi, M., Musante, L., Santucci, L. et al., Blue silver: a very sensitive colloidal Coomassie G-250 staining for proteome analysis. Electrophoresis 2004, 25, 1327-1333.
34. Bruschi, M., Musante, L., Candiano, G., Ghiggeri, G. M. et al., Soft immobilized pH gradient gels in proteome analysis: a follow-up. Proteomics 2003, 3, 821-825.