Thyroid stunning: Fact or fiction?

Seminars in Nuclear Medicine

Volumn 41, Issue 2, 2011, Pages 105-112

  McDougall, I Ross ^a   Iagaru, Andrei ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; IODINE; IODINE 131; THYROTROPIN;

ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DIAGNOSTIC TEST; FOLLOW UP; HUMAN; SENSITIVITY AND SPECIFICITY; THYROID CANCER; THYROID DISEASE; THYROID SCINTISCANNING; THYROID STUNNING; THYROIDECTOMY;

EID: 79251513658     PISSN: 00012998     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semnuclmed.2010.10.004     Document Type: Review

References (54)

1. H. Yagcloglu, E. Ozalp, and E. Ibis Partial stunning in thyroid remnant after administration of scanning dose followed by 100 mCi I-131 therapy Clin Nucl Med 21 1996 340
2. A.J. Coakley Thyroid stunning Eur J Nucl Med 25 1998 203 204
3. O. Sabri, M. Zimny, and M. Schreckenberger Does thyroid stunning exist? A model with benign thyroid disease Eur J Nucl Med 27 2000 1591 1597
4. M. Medvedec Thyroid stunning J Nucl Med 42 2001 1129 1131
5. W. Brenner Is thyroid stunning a real phenomenon or just fiction? J Nucl Med 43 2002 835 836
6. K.C. Allman Thyroid stunning revisited J Nucl Med 44 2003 1194
7. L.F. Morris, A.D. Waxman, and G.D. Braunstein Thyroid stunning Thyroidology 13 2003 333 340
8. J.C. Sisson, A.M. Avram, and S.A. Lawson The so-called stunning of thyroid tissue J Nucl Med 47 2006 1406 1412
9. J.M. Woolfenden Thyroid stunning revisited J Nucl Med 47 2006 1403 1405
10. S.K. Gerard, and H.M. Park Stunning effect J Nucl Med 48 2007 328 329 author reply: 329-330
11. T.E. Hilditch, A.A. Bolster, and M.F. Dempsey The so-called stunning of thyroid tissue J Nucl Med 48 2007 675 676 author reply: 676
12. M. Filesi, M. Colandrea, and T. Montesano Thyroid stunning in clinical practice: is it a real problem? Minerva Endocrinol 34 2008 29 36
13. M. Filesi, M. Colandrea, and T. Montesano Thyroid stunning in clinical practice: is it a real problem? Minerva Endocrinol 34 2009 29 36
14. J.E. Kalinyak, and I.R. McDougall Whole-body scanning with radionuclides of iodine, and the controversy of "thyroid stunning" Nucl Med Commun 25 2004 883 889
15. R.W. Rawson, and L.D. Marinelli The effect of total thyroidectomy on the function of metastatic thyroid cancer J Clin Endocrinol Metab 8 1948 826 841
16. S.M. Seidlin, L.D. Marinelli, and E. Oshry Radioactive iodine therapy; effect on functioning metastases of adenocarcinoma of the thyroid JAMA 132 1946 838 847
17. S.M. Seidlin, E. Oshry, and A.A. Yalow Spontaneous and experimentally induced uptake of radioactive iodine in metastases from thyroid carcinoma; a preliminary report J Clin Endocrinol Metab 8 1948 423 432
18. J. Nemec, S. Rohling, and V. Zamrazil Comparison of the distribution of diagnostic and thyroablative I-131 in the evaluation of differentiated thyroid cancers J Nucl Med 20 1979 92 97
19. S. Balachandran, and B.A. Sayle Value of thyroid carcinoma imaging after therapeutic doses of radioiodine Clin Nucl Med 6 1981 162 167
20. R.A. Preisman, and S. Halpern Detection of metastatic thyroid carcinoma after the administration of a therapeutic dose of 131-iodine Eur J Nucl Med 3 1978 69 70
21. A. Waxman, L. Ramanna, and N. Chapman The significance of 1-131 scan dose in patients with thyroid cancer: determination of ablation: concise communication J Nucl Med 22 1981 861 865
22. F. Pacini, F. Lippi, and N. Formica Therapeutic doses of iodine-131 reveal undiagnosed metastases in thyroid cancer patients with detectable serum thyroglobulin levels J Nucl Med 28 1987 1888 1891
23. R.W. Rawson, J.E. Rall, and W. Peacock Limitations and indications in the treatment of cancer of the thyroid with radioactive iodine J Clin Endocrinol Metab 11 1951 1128 1142
24. H.M. Park Stunned thyroid after high-dose I-131 imaging Clin Nucl Med 17 1992 501 502
25. R.K. Jeevanram, D.H. Shah, and S.M. Sharma Influence of initial large dose on subsequent uptake of therapeutic radioiodine in thyroid cancer patients Int J Radiol Appl Instrum B 13 1986 277 279
26. H.M. Park, O.W. Perkins, and J.W. Edmondson Influence of diagnostic radioiodines on the uptake of ablative dose of iodine-131 Thyroidology 4 1994 49 54
27. H.M. Park, Y.H. Park, and X.H. Zhou Detection of thyroid remnant/metastasis without stunning: an ongoing dilemma Thyroidology 7 1997 277 280
28. D. Huic, M. Medvedec, and D. Dodig Radioiodine uptake in thyroid cancer patients after diagnostic application of low-dose 131I Nucl Med Commun 17 1996 839 842
29. J.P. Muratet, A. Daver, and J.F. Minier Influence of scanning doses of iodine-131 on subsequent first ablative treatment outcome in patients operated on for differentiated thyroid carcinoma J Nucl Med 39 1998 1546 1550
30. H.W. Yeung, J.L. Humm, and S.M. Larson Radioiodine uptake in thyroid remnants during therapy after tracer dosimetry J Nucl Med 41 2000 1082 1085
31. F.A. Leger, M. Izembart, and F. Dagousset Decreased uptake of therapeutic doses of iodine-131 after 185-MBq iodine-131 diagnostic imaging for thyroid remnants in differentiated thyroid carcinoma Eur J Nucl Med 25 1998 242 246
32. 131 I Nuklearmedizin 48 2009 138 142 quiz N119-120
33. H.S. Wu, H.H. Hseu, and W.Y. Lin Decreased uptake after fractionated ablative doses of iodine-131 Eur J Nucl Med Mol Imaging 32 2005 167 173
34. E. Arad, K. Flannery, and G.A. Wilson Fractionated doses of radioiodine for ablation of postsurgical thyroid tissue remnants Clin Nucl Med 15 1990 676 677
35. A.F. Leger, M. Pellan, and F. Dagousset A case of stunning of lung and bone metastases of papillary thyroid cancer after a therapeutic dose (3.7 GBq) of 131I and review of the literature: implications for sequential treatments Br J Radiol 78 2005 428 432
36. I.R. McDougall 74 megaBecquerels radioiodine 131I does not prevent uptake of therapeutic doses of 131I i.e. it does not cause stunning) in differentiated thyroid cancer Nucl Med Commun 18 1997 505 512
37. L.F. Morris, A.D. Waxman, and G.D. Braunstein The nonimpact of thyroid stunning: remnant ablation rates in 131I-scanned and nonscanned individuals J Clin Endocrinol Metab 86 2001 3507 3511
38. S.P. Cholewinski, K.S. Yoo, and P.S. Klieger Absence of thyroid stunning after diagnostic whole-body scanning with 185 MBq 131I J Nucl Med 41 2000 1198 1202
39. M.T. Bajen, S. Mane, and A. Munoz Effect of a diagnostic dose of 185 MBq 131I on postsurgical thyroid remnants J Nucl Med 41 2000 2038 2042
40. T.E. Hilditch, M.F. Dempsey, and A.A. Bolster Self-stunning in thyroid ablation: evidence from comparative studies of diagnostic 131I and 123I Eur J Nucl Med Mol Imaging 29 2002 783 788
41. F. Guiraud-Vitaux, G. Feldmann, and N. Vadrot Early ultrastructural injuries in the thyroid of the normal rat radioinduced by diagnostic and/or therapeutic amounts of iodine-131 Cell Mol Biol Noisy Le Grand 47 2001 495 502
42. P.W. Rosario, A.L. Barroso, and L.L. Rezende 5 millicuries pretreatment scanning does not cause stunning when the ablative dose is administered within 72 hours Arq Bras Endocrinol Metab Jun 49 2005 420 424
43. H.Q. Dam, S.M. Kim, and H.C. Lin 131I therapeutic efficacy is not influenced by stunning after diagnostic whole-body scanning Radiology 232 2004 527 533
44. E.B. Silberstein Comparison of outcomes after (123)I versus 131I pre-ablation imaging before radioiodine ablation in differentiated thyroid carcinoma J Nucl Med 48 2007 1043 1046
45. M. Karam, A. Gianoukakis, and P.J. Feustel Influence of diagnostic and therapeutic doses on thyroid remnant ablation rates Nucl Med Commun 24 2003 489 495
46. M. Nordn, F. Larsson, and S. Tedelind Down-regulation of the sodium/iodide symporter explains 131I-induced thyroid stunning Cancer Res 67 2007 7512 7517
47. B. Meller, E. Gaspar, and W. Deisting Decreased radioiodine uptake of FRTL-5 cells after (131)I incubation in vitro: molecular biological investigations indicate a cell cycle-dependent pathway Eur J Nucl Med Mol Imaging 35 2008 1204 1212
48. P. Postgard, J. Himmelman, and U. Lindencrona Stunning of iodide transport by (131)I irradiation in cultured thyroid epithelial cells J Nucl Med 43 2002 828 834
49. C. Lundh, U. Lindencrona, and P. Postgard Radiation-induced thyroid stunning: differential effects of (123) I 131I, (99m)Tc, and (211)At on iodide transport and NIS mRNA expression in cultured thyroid cells J Nucl Med 50 2009 1161 1167
50. M.J. Dong, Z.F. Liu, and K. Zhao Value of 18F-FDG-PET/PET-CT in differentiated thyroid carcinoma with radioiodine-negative whole-body scan: a meta-analysis Nucl Med Commun 30 2009 639 650
51. M. Urhan, S. Dadparvar, and A. Mavi Iodine-123 as a diagnostic imaging agent in differentiated thyroid carcinoma: a comparison with iodine-131 post-treatment scanning and serum thyroglobulin measurement Eur J Nucl Med Mol Imaging 34 2007 1012 1017
52. D. Van Nostrand, M. Aiken, and F. Atkins The utility of radioiodine scans prior to iodine 131 ablation in patients with well-differentiated thyroid cancer Thyroidology 19 2009 849 855
53. I.R. McDougall The case for obtaining a diagnostic whole-body scan prior to iodine-131 treatment of differentiated thyroid cancer Thyroidology 19 2009 811 813
54. S.S.H. Kueh, P. Roach, and G. Schembri Role of Tc-99m pertechnetate for remnant scintigraphy post-thyroidectomy Clin Nucl Med 35 2010 671 674