Mutagenic potential and modulatory effects of the medicinal plant Luehea divaricata (Malvaceae) in somatic cells of Drosophila melanogaster: SMART/wing

Genetics and Molecular Research

Volumn 10, Issue 1, 2011, Pages 16-24

  Felicio L P ^a   Silva, E M ^a   Ribeiro, V ^a   Miranda, C T ^b   Vieira, I L B F ^a   Passos, D C S ^a   Ferreira, A K S ^a   Vale, C R ^a   Lima, D C S ^a   Carvalho, S ^a   Nunes, W B ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b UNIVERSITY OF BRASILIA   (Brazil)

Author keywords

Anti genotoxicity; Drosophila melanogaster; Genotoxicity; Luehea divaricata; Smart wing

Indexed keywords

DOXORUBICIN; LUEHEA DIVARICATA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANGIOSPERM; ANIMAL CELL; ARTICLE; BARK; COMBINATION CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DROSOPHILA MELANOGASTER; GENE MUTATION; GENOTOXICITY; LUEHEA DIVARICATA; MEDICINAL PLANT; MONOTHERAPY; MUTAGENICITY; NONHUMAN; RECOMBINANT DNA TECHNOLOGY; SOMATIC CELL; SOMATIC MUTATION; TOXICITY TESTING;

ANIMALS; DOXORUBICIN; DROSOPHILA MELANOGASTER; MALVACEAE; MUTAGENICITY TESTS; MUTAGENS; MUTATION; PLANT EXTRACTS; PLANTS, MEDICINAL; SURVIVAL ANALYSIS; WING;

DROSOPHILA MELANOGASTER; LUEHEA; MALVACEAE;

EID: 79251508349     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/vol10-1gmr982     Document Type: Article

References (27)

1. Artavanis-Tsakonas S, Matsuno K and Fortini ME (1995). Notch signaling. Science 268: 225-232.
2. Balbach A (1993). As Plantas Curam. Editora Missionária, Itaquaquecetuba.
3. Calixto JB (2000). Biopirataria - A Diversidade Biológica na Mira da Indústria Farmacêutica. Ciência Hoje, Rio de Janeiro. 36-43.
4. Campelo PMS (2006). Plantas Medicinais e Seus Extratos: A Necessidade de Estudos Continuados. Estud. Biol. 28: 62.
5. Carvalho JE (2006). Atividade antiulcerogênica e anticâncer de produtos naturais e de síntese. Multiciência 7: 1-18.
6. Franchi LP, Guimarães NN, Lehmann M, Andrade HHR, et al. (2008). Ausência de efeito tóxicogênico de Morinda citrifolia (NONI) em células somática de Drosophila melanogaster. Rev. Eletrônica Farm. 5: 46-536.
7. Frei H and Würgler FE (1988). Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative, or inconclusive result. Mutat. Res. 203: 297-308.
8. Frei H and Würgler FE (1995). Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila. Mutat. Res. 334: 247-258.
9. Giulietti AM, Harley RM, Queiroz LP, Wanderley MG, et al. (2005). Biodiversidade e conservação das plantas no Brasil. Megadiversidade 1: 52-61. Avaliable at [http://www.agencia.cnptia.embrapa.br/recursos/BIOD_ConservacaoIDeWNPNpKEJw.pdf]. Accessed November 22, 2010.
10. Graf U and van Schaik N (1992). Improved high bioactivation cross for the wing somatic mutation and recombination test in Drosophila melanogaster. Mutat. Res. 271: 59-67.
11. Graf U, Wurgler FE, Katz AJ, Frei H, et al. (1984). Somatic mutation and recombination test in Drosophila melanogaster. Environ. Mutagen. 6: 153-188.
12. Graf U, Frei H, Kagi A, Katz AJ, et al. (1989). Thirty compounds tested in the Drosophila wing spot test. Mutat. Res. 222: 359-373.
13. Gusmán-Rincón J and Graf U (1995). Drosophila melanogaster Somatic Mutation and Recombination Test as a Biomonitor. In: Biomonitors and Biomarkers as Indicators of Environmental Change. Plenum Press, New York, 169-181.
14. o edição. Fundação Integrada Municipal de Ensino Superior, Mineiros.
15. Lorenzi H (1998). Árvores Brasileiras: Manual de Identificação e Cultivo de Plantas Arbóreas Nativas do Brasil. Plantarum, Nova Odessa.
16. Mendanha DM, Ferreira HD, Felicio LP, Silva EM, et al. (2010). Modulatory effect of Byrsonima verbascifolia (Malpighiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster. Genet. Mol. Res. 9: 69-77.
17. Miklos GL and Rubin GM (1996). The role of the genome project in determining gene function: insights from model organisms. Cell 86: 521-529.
18. a Reunião Anual da SBPC, Florianópolis.
19. Nunes WB (2004). Efeito Modulador do Extrato Aquoso Padronizado de Ginkgo biloba (EGb 761) Contra Mutações e Recombinações Somáticas Induzidas pela Doxorrubicina em Células Somáticas de Drosophila melanogaster. Doctoral thesis, UFU, Uberlândia.
20. a edição. Elsevier, Rio de Janeiro.
21. Passos DC, Ferreira HD, Vieira IL, Nunes WB, et al. (2010). Modulatory effect of Palicourea coriacea (Rubiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster. Genet. Mol. Res. 9: 1153-1162.
22. Robert J and Gianni L (1993). Pharmacokinetics and metabolism of anthracyclines. Cancer Surv. 17: 219-252.
23. Saner C, Weibel B, Wurgler FE and Sengstag C (1996). Metabolism of promutagens catalyzed by Drosophila melanogaster CYP6A2 enzyme in Saccharomyces cerevisiae. Environ. Mol. Mutagen. 27: 46-58.
24. Silva LD, Nascimento V, Santos SC, Morais JOR, et al. (2003). Análise morfométrica das células de cloro de Poecilia vivipara expostas a frações da folha e da casca do caule de Caryocar brasiliensis. Portal de Periódicos da UEM. Available at [http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/viewFile/2107/1545]. Accessed November 22, 2010.
25. Siqueira MG (2006). Atividade Antiulcerogênica do Extrato Bruto Hidroalcoólico da Luehea divaricata Martus et Zuccarini. 100 f. Master's thesis, UNICAMP, Campinas.
26. Takeuchi PL, Antunes LM and Takahashi CS (2007). Evaluation of the clastogenicity and anticlastogenicity of vitamin B6 in human lymphocyte cultures. Toxicol. In Vitro 21: 665-670.
27. Tanaka JCA, Silva CC, Dias Filho BP and Nakamura CV (2005). Constituintes Químicos de Luehea divaricata Mart. (Tiliaceae). Quím. Nova 5: 834-837.