Human hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein cures fas-induced acute liver failure in mice by attenuating free-radical damage in injured livers

Hepatology

Volumn 53, Issue 2, 2011, Pages 618-627

  Moniaux, Nicolas ^a,b   Song, Haiyan ^a,b   Darnaud, Marion ^a,b   Garbin, Kévin ^a,b   Gigou, Michelle ^a,b   Mitchell, Claudia ^a   Samuel, Didier ^a,b   Jamot, Laure ^c   Amouyal, Paul ^c   Amouyal, Gilles ^c   Bréchot, Christian ^a,b   Faivre, Jamila ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c Alfact Innovation   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CASPASE 3; DACTINOMYCIN; FAS ANTIBODY; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; FREE RADICAL; HYDROGEN PEROXIDE; LECTIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL XL; PROTEIN BID; REACTIVE OXYGEN METABOLITE; RECOMBINANT PANCREATITIS ASSOCIATED PROTEIN; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE LIVER FAILURE; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; CELL PROLIFERATION; CELL STRESS; CELL VIABILITY; CONTROLLED STUDY; DISTRIBUTION VOLUME; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE ESCALATION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; HUMAN EXPERIMENT; LIVER CELL; LIVER INJURY; MALE; MORTALITY; MOUSE; NONHUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; OXIDATIVE STRESS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAT; RECOMMENDED DRUG DOSE; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TISSUE REGENERATION; TRANSGENIC MOUSE;

ADOLESCENT; ADULT; ANIMALS; ANTIGENS, CD95; ANTIGENS, NEOPLASM; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG-INDUCED LIVER INJURY; FREE RADICAL SCAVENGERS; FREE RADICALS; HEPATOCYTES; HUMANS; LECTINS, C-TYPE; LIPID PEROXIDATION; LIVER FAILURE, ACUTE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDDLE AGED; RECOMBINANT PROTEINS; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 79251508317     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24087     Document Type: Article

References (17)

1. Stravitz RT, Kramer DJ. Management of acute liver failure. Nat Rev Gastroenterol Hepatol 2009; 6: 542-553.
2. Shen HM, Pervaiz S. TNF receptor superfamily-induced cell death: redox-dependent execution. FASEB J 2006; 20: 1589-1598.
3. Bedda S, Laurent A, Conti F, Chereau C, Tran A, Tran-Van NJ, et al. Mangafodipir prevents liver injury induced by acetaminophen in the mouse. J Hepatol 2003; 39: 765-772.
4. Bustos M, Beraza N, Lasarte JJ, Baixeras E, Alzuguren P, Bordet T, et al. Protection against liver damage by cardiotrophin-1: a hepatocyte survival factor up-regulated in the regenerating liver in rats. Gastroenterology 2003; 125: 192-201.
5. Eichhorst ST, Krueger A, Muerkoster S, Fas SC, Golks A, Gruetzner U, et al. Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice. Nat Med 2004; 10: 602-609.
6. Lieu HT, Batteux F, Simon MT, Cortes A, Nicco C, Zavala F, et al. HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice. HEPATOLOGY 2005; 42: 618-626.
7. Lieu HT, Simon MT, Nguyen-Khoa T, Kebede M, Cortes A, Tebar L, et al. Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice. HEPATOLOGY 2006; 44: 1452-1464.
8. Lee WM, Hynan LS, Rossaro L, Fontana RJ, Stravitz RT, Larson AM, et al. Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. Gastroenterology 2009; 137: 856-864, 864.
9. Gironella M, Folch-Puy E, LeGoffic A, Garcia S, Christa L, Smith A, et al. Experimental acute pancreatitis in PAP/HIP knock-out mice. Gut 2007; 56: 1091-1097.
10. Simon MT, Pauloin A, Normand G, Lieu HT, Mouly H, Pivert G, et al. HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotic functions through the PKA signaling pathway. FASEB J 2003; 17: 1441-1450.
11. Nishimune H, Vasseur S, Wiese S, Birling MC, Holtmann B, Sendtner M, et al. Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway. Nat Cell Biol 2000; 2: 906-914.
12. Malka D, Vasseur S, Bodeker H, Ortiz EM, Dusetti NJ, Verrando P, et al. Tumor necrosis factor alpha triggers antiapoptotic mechanisms in rat pancreatic cells through pancreatitis-associated protein I activation. Gastroenterology 2000; 119: 816-828.
13. Walter D, Schmich K, Vogel S, Pick R, Kaufmann T, Hochmuth FC, et al. Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes. HEPATOLOGY 2008; 48: 1942-1953.
14. Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120: 649-661.
15. Volkmann X, Anstaett M, Hadem J, Stiefel P, Bahr MJ, Lehner F, et al. Caspase activation is associated with spontaneous recovery from acute liver failure. HEPATOLOGY 2008; 47: 1624-1633.
16. Hinge A, Bajaj M, Limaye L, Surolia A, Kale V. Oral administration of insulin receptor-interacting lectins leads to an enhancement in the hematopoietic stem and progenitor cell pool of mice. Stem Cells Dev 2010; 19: 163-174.
17. Abergel C, Chenivesse S, Stinnakre MG, Guasco S, Brechot C, Claverie JM, et al. Crystallization and preliminary crystallographic study of HIP/PAP, a human C-lectin overexpressed in primary liver cancers. Acta Crystallogr D Biol Crystallogr 1999; 55: 1487-1489.