Selective transmission of R5 HIV-1 variants: Where is the gatekeeper?

Journal of Translational Medicine

Volumn 9, Issue SUPPL. 1, 2010, Pages

  Grivel, Jean Charles ^a   Shattock, Robin J ^b   Margolis, Leonid B ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120;

ANUS INTERCOURSE; ARTICLE; BODY FLUID; CD4+ T LYMPHOCYTE; DISEASE COURSE; GASTROINTESTINAL MUCOSA; GENETIC POLYMORPHISM; HETEROSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFECTION SENSITIVITY; NONHUMAN; ORAL SEXUAL CONTACT; PATHOGENESIS; PHENOTYPE; PROTECTION; PROTEIN FUNCTION; SEQUENCE ANALYSIS; SEXUAL TRANSMISSION; TARGET CELL; UTERINE CERVIX MUCUS; VERTICAL TRANSMISSION; VIRAL TROPISM; VIRUS CELL INTERACTION; VIRUS CLASSIFICATION; VIRUS ENTRY; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TRANSMISSION; CHEMISTRY; DISEASE TRANSMISSION; FEMALE; GENETIC VARIABILITY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; INTESTINE MUCOSA; MALE; METABOLISM; REVIEW; STATISTICAL MODEL; STOMACH MUCOSA; VIROLOGY;

FEMALE; GASTRIC MUCOSA; GENETIC VARIATION; HIV INFECTIONS; HIV-1; HUMANS; INTESTINAL MUCOSA; MALE; MODELS, STATISTICAL; PHENOTYPE; POLYMORPHISM, GENETIC; RECEPTORS, CCR5; RECEPTORS, CXCR4;

EID: 79251508013     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-9-S1-S6     Document Type: Article

References (194)

1. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996, 272:1955-1958. 10.1126/science.272.5270.1955, 8658171.
2. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996, 381:661-666. 10.1038/381661a0, 8649511.
3. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxton WA. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996, 381:667-673. 10.1038/381667a0, 8649512.
4. Berger EA, Doms RW, Fenyo EM, Korber BT, Littman DR, Moore JP, Sattentau QJ, Schuitemaker H, Sodroski J, Weiss RA. A new classification for HIV-1. Nature 1998, 391:240. 10.1038/34571, 9440686.
5. Moore JP, Kitchen SG, Pugach P, Zack JA. The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses 2004, 20:111-126. 10.1089/088922204322749567, 15000703.
6. Keele BF, Derdeyn CA. Genetic and antigenic features of the transmitted virus. Curr Opin HIV AIDS 2009, 4:352-357. 10.1097/COH.0b013e32832d9fef, 20048697.
7. Salazar-Gonzalez JF, Salazar MG, Keele BF, Learn GH, Giorgi EE, Li H, Decker JM, Wang S, Baalwa J, Kraus MH, et al. Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection. J Exp Med 2009, 206:1273-1289. 10.1084/jem.20090378, 2715054, 19487424.
8. Vahlne A. A historical reflection on the discovery of human retroviruses. Retrovirology 2009, 6:40. 10.1186/1742-4690-6-40, 2686671, 19409074.
9. Gottlieb MS, Schroff R, Schanker HM, Weisman JD, Fan PT, Wolf RA, Saxon A. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl J Med 1981, 305:1425-1431. 10.1056/NEJM198112103052401, 6272109.
10. Klatzmann D, Barre-Sinoussi F, Nugeyre MT, Danquet C, Vilmer E, Griscelli C, Brun-Veziret F, Rouzioux C, Gluckman JC, Chermann JC, et al. Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes. Science 1984, 225:59-63. 10.1126/science.6328660, 6328660.
11. Popovic M, Read-Connole E, Gallo RC. T4 positive human neoplastic cell lines susceptible to and permissive for HTLV-III. Lancet 1984, 2:1472-1473. 10.1016/S0140-6736(84)91666-0, 6151082.
12. Klatzmann D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercend T, Gluckman JC, Montagnier L. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 1984, 312:767-768. 10.1038/312767a0, 6083454.
13. Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 1986, 47:333-348. 10.1016/0092-8674(86)90590-8, 3094962.
14. Chesebro B, Buller R, Portis J, Wehrly K. Failure of human immunodeficiency virus entry and infection in CD4-positive human brain and skin cells. Journal of virology 1990, 64:215-221. 249089, 2293663.
15. McDougal JS, Klatzmann DR, Maddon PJ. CD4-gp120 interactions. Curr Opin Immunol 1991, 3:552-558. 10.1016/0952-7915(91)90020-2, 1721822.
16. Benn S, Rutledge R, Folks T, Gold J, Baker L, McCormick J, Feorino P, Piot P, Quinn T, Martin M. Genomic heterogeneity of AIDS retroviral isolates from North America and Zaire. Science 1985, 230:949-951. 10.1126/science.2997922, 2997922.
17. Hahn BH, Gonda MA, Shaw GM, Popovic M, Hoxie JA, Gallo RC, Wong-Staal F. Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes. Proc Natl Acad Sci U S A 1985, 82:4813-4817. 10.1073/pnas.82.14.4813, 390995, 2991896.
18. Wong-Staal F, Shaw GM, Hahn BH, Salahuddin SZ, Popovic M, Markham P, Redfield R, Gallo RC. Genomic diversity of human T-lymphotropic virus type III (HTLV-III). Science 1985, 229:759-762. 10.1126/science.2992084, 2992084.
19. di Marzo Veronese F, Sarngadharan MG, Rahman R, Markham PD, Popovic M, Bodner AJ, Gallo RC. Monoclonal antibodies specific for p24, the major core protein of human T-cell leukemia virus type III. Proc Natl Acad Sci U S A 1985, 82:5199-5202. 10.1073/pnas.82.15.5199, 390527, 2991911.
20. Brun-Vezinet F, Rouzioux C, Barre-Sinoussi F, Klatzmann D, Saimot AG, Rozenbaum W, Christol D, Gluckmann JC, Montagnier L, Chermann JC. Detection of IgG antibodies to lymphadenopathy-associated virus in patients with AIDS or lymphadenopathy syndrome. Lancet 1984, 1:1253-1256. 10.1016/S0140-6736(84)92444-9, 6144973.
21. Palker TJ, Scearce RM, Miller SE, Popovic M, Bolognesi DP, Gallo RC, Haynes BF. Monoclonal antibodies against human T cell leukemia-lymphoma virus (HTLV) p24 internal core protein. Use as diagnostic probes and cellular localization of HTLV. J Exp Med 1984, 159:1117-1131. 10.1084/jem.159.4.1117, 2187274, 6323615.
22. Schupbach J, Haller O, Vogt M, Luthy R, Joller H, Oelz O, Popovic M, Sarngadharan MG, Gallo RC. Antibodies to HTLV-III in Swiss patients with AIDS and pre-AIDS and in groups at risk for AIDS. N Engl J Med 1985, 312:265-270. 10.1056/NEJM198501313120502, 2981407.
23. Barrett JE, Dawson G, Heller J, Bairstow C, Fico R, Webber JS, Gutierrez R, Decker RH. Performance evaluation of the Abbott HTLV III EIA, a test for antibody to HTLV III in donor blood. Am J Clin Pathol 1986, 86:180-185.
24. Gallo D, Diggs JL, Shell GR, Dailey PJ, Hoffman MN, Riggs JL. Comparison of detection of antibody to the acquired immune deficiency syndrome virus by enzyme immunoassay, immunofluorescence, and Western blot methods. J Clin Microbiol 1986, 23:1049-1051. 268791, 3011854.
25. Jackson B, Sannerud K, Rhame F, Tsang R, Balfour HH. Comparison of reverse transcriptase assay with the Retro-Tek viral capture assay for detection of human immunodeficiency virus. Diagn Microbiol Infect Dis 1987, 7:185-192. 10.1016/0732-8893(87)90003-4, 2443299.
26. Kaplan MH, Pahwa SG, Popovic M, Sarngadharan MG, Gallo RC. A classification of HTLV-III infection based on 75 cases seen in a suburban community. Cancer Res 1985, 45:4655s-4658s.
27. Asjo B, Morfeldt-Manson L, Albert J, Biberfeld G, Karlsson A, Lidman K, Fenyo EM. Replicative capacity of human immunodeficiency virus from patients with varying severity of HIV infection. Lancet 1986, 2:660-662.
28. Cheng-Mayer C, Seto D, Tateno M, Levy JA. Biologic features of HIV-1 that correlate with virulence in the host. Science 1988, 240:80-82. 10.1126/science.2832945, 2832945.
29. Castro BA, Cheng-Mayer C, Evans LA, Levy JA. HIV heterogeneity and viral pathogenesis. Aids 1988, 2(Suppl 1):S17-27. 10.1097/00002030-198800001-00004, 3147667.
30. Sakai K, Dewhurst S, Ma XY, Volsky DJ. Differences in cytopathogenicity and host cell range among infectious molecular clones of human immunodeficiency virus type 1 simultaneously isolated from an individual. J Virol 1988, 62:4078-4085. 253838, 3172338.
31. Fredriksson R, Stalhanske P, von Gegerfelt A, Lind B, Aman P, Rassart E, Fenyo EM. Biological characterization of infectious molecular clones derived from a human immunodeficiency virus type-1 isolate with rapid/high replicative capacity. Virology 1991, 181:55-61. 10.1016/0042-6822(91)90469-R, 1704660.
32. Fernandez-Larsson R, Srivastava KK, Lu S, Robinson HL. Replication of patient isolates of human immunodeficiency virus type 1 in T cells: a spectrum of rates and efficiencies of entry. Proc Natl Acad Sci U S A 1992, 89:2223-2226. 10.1073/pnas.89.6.2223, 48629, 1549586.
33. De Rossi A, Giaquinto C, Ometto L, Mammano F, Zanotto C, Dunn D, Chieco-Bianchi L. Replication and tropism of human immunodeficiency virus type 1 as predictors of disease outcome in infants with vertically acquired infection. J Pediatr 1993, 123:929-936. 10.1016/S0022-3476(05)80389-0, 7901357.
34. Scarlatti G, Hodara V, Rossi P, Muggiasca L, Bucceri A, Albert J, Fenyo EM. Transmission of human immunodeficiency virus type 1 (HIV-1) from mother to child correlates with viral phenotype. Virology 1993, 197:624-629. 10.1006/viro.1993.1637, 8249285.
35. Lifson JD, Reyes GR, McGrath MS, Stein BS, Engleman EG. AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen. Science 1986, 232:1123-1127. 10.1126/science.3010463, 3010463.
36. Epstein LG, Sharer LR, Cho ES, Myenhofer M, Navia B, Price RW. HTLV-III/LAV-like retrovirus particles in the brains of patients with AIDS encephalopathy. AIDS Res 1984, 1:447-454.
37. Tersmette M, de Goede RE, Al BJ, Winkel IN, Gruters RA, Cuypers HT, Huisman HG, Miedema F. Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. J Virol 1988, 62:2026-2032. 253287, 3130494.
38. Fenyo EM, Morfeldt-Manson L, Chiodi F, Lind B, von Gegerfelt A, Albert J, Olausson E, Asjo B. Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates. J Virol 1988, 62:4414-4419. 253886, 2459416.
39. Schuitemaker H, Kootstra NA, de Goede RE, de Wolf F, Miedema F, Tersmette M. Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture. J Virol 1991, 65:356-363. 240525, 1985204.
40. Tersmette M, Gruters RA, de Wolf F, de Goede RE, Lange JM, Schellekens PT, Goudsmit J, Huisman HG, Miedema F. Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates. J Virol 1989, 63:2118-2125. 250628, 2564898.
41. Gruters RA, Terpstra FG, De Goede RE, Mulder JW, De Wolf F, Schellekens PT, Van Lier RA, Tersmette M, Miedema F. Immunological and virological markers in individuals progressing from seroconversion to AIDS. Aids 1991, 5:837-844. 10.1097/00002030-199107000-00007, 1892588.
42. Koot M, Keet IP, Vos AH, de Goede RE, Roos MT, Coutinho RA, Miedema F, Schellekens PT, Tersmette M. Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med 1993, 118:681-688.
43. Gendelman HE, Orenstein JM, Martin MA, Ferrua C, Mitra R, Phipps T, Wahl LA, Lane HC, Fauci AS, Burke DS, et al. Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med 1988, 167:1428-1441. 10.1084/jem.167.4.1428, 2188914, 3258626.
44. Schwartz S, Felber BK, Fenyo EM, Pavlakis GN. Rapidly and slowly replicating human immunodeficiency virus type 1 isolates can be distinguished according to target-cell tropism in T-cell and monocyte cell lines. Proc Natl Acad Sci U S A 1989, 86:7200-7203. 10.1073/pnas.86.18.7200, 298024, 2789383.
45. Fenyo EM, Albert J, Asjo B. Replicative capacity, cytopathic effect and cell tropism of HIV. AIDS 1989, 3(Suppl 1):S5-12. 10.1097/00002030-198901001-00002, 2514754.
46. Valentin A, Albert J, Fenyo EM, Asjo B. HIV-1 infection of normal human macrophage cultures: implication for silent infection. Virology 1990, 177:790-794. 10.1016/0042-6822(90)90551-2, 2371782.
47. Valentin A, Albert J, Fenyo EM, Asjo B. Dual tropism for macrophages and lymphocytes is a common feature of primary human immunodeficiency virus type 1 and 2 isolates. J Virol 1994, 68:6684-6689. 237089, 7521920.
48. Harada S, Koyanagi Y, Yamamoto N. Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay. Science 1985, 229:563-566. 10.1126/science.2992081, 2992081.
49. Koot M, Vos AH, Keet RP, de Goede RE, Dercksen MW, Terpstra FG, Coutinho RA, Miedema F, Tersmette M. HIV-1 biological phenotype in long-term infected individuals evaluated with an MT-2 cocultivation assay. Aids 1992, 6:49-54. 10.1097/00002030-199201000-00006, 1543566.
50. Schuitemaker H, Koot M, Kootstra NA, Dercksen MW, de Goede RE, van Steenwijk RP, Lange JM, Schattenkerk JK, Miedema F, Tersmette M. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. J Virol 1992, 66:1354-1360. 240857, 1738194.
51. Karlsson A, Parsmyr K, Sandstrom E, Fenyo EM, Albert J. MT-2 cell tropism as prognostic marker for disease progression in human immunodeficiency virus type 1 infection. J Clin Microbiol 1994, 32:364-370. 263037, 7908672.
52. Schneider T, Jahn HU, Schmidt W, Riecken EO, Zeitz M, Ullrich R. Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Berlin Diarrhea/Wasting Syndrome Study Group. Gut 1995, 37:524-529. 10.1136/gut.37.4.524, 1382905, 7489940.
53. Bishop PE, McMillan A, Gilmour HM. Immunological study of the rectal mucosa of men with and without human immunodeficiency virus infection. Gut 1987, 28:1619-1624. 10.1136/gut.28.12.1619, 1433915, 2962908.
54. Collman R, Godfrey B, Cutilli J, Rhodes A, Hassan NF, Sweet R, Douglas SD, Friedman H, Nathanson N, Gonzalez-Scarano F. Macrophage-tropic strains of human immunodeficiency virus type 1 utilize the CD4 receptor. J Virol 1990, 64:4468-4476. 247917, 2200889.
55. Cordonnier A, Montagnier L, Emerman M. Single amino-acid changes in HIV envelope affect viral tropism and receptor binding. Nature 1989, 340:571-574. 10.1038/340571a0, 2475780.
56. O'Brien WA, Koyanagi Y, Namazie A, Zhao JQ, Diagne A, Idler K, Zack JA, Chen IS. HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain. Nature 1990, 348:69-73. 10.1038/348069a0, 2172833.
57. Schuitemaker H, Groenink M, Tersmette M, Miedema F. HIV tropism. Nature 1993, 361:310. 10.1038/361310a0, 8426651.
58. Weiner DB, Huebner K, Williams WV, Greene MI. Human genes other than CD4 facilitate HIV-1 infection of murine cells. Pathobiology 1991, 59:361-371. 10.1159/000163679, 1930688.
59. Alkhatib G, Broder CC, Berger EA. Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages. J Virol 1996, 70:5487-5494. 190506, 8764060.
60. Harrington RD, Geballe AP. Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line. J Virol 1993, 67:5939-5947. 238014, 7690415.
61. Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996, 272:872-877. 10.1126/science.272.5263.872, 8629022.
62. Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, Springer TA. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996, 382:829-833. 10.1038/382829a0, 8752280.
63. Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, et al. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 1996, 382:833-835. 10.1038/382833a0, 8752281.
64. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV- suppressive factors produced by CD8+ T cells. Science 1995, 270:1811-1815. 10.1126/science.270.5243.1811, 8525373.
65. Combadiere C, Ahuja SK, Tiffany HL, Murphy PM. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. J Leukoc Biol 1996, 60:147-152.
66. Raport CJ, Gosling J, Schweickart VL, Gray PW, Charo IF. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha. J Biol Chem 1996, 271:17161-17166. 10.1074/jbc.271.29.17161, 8663314.
67. Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 1996, 35:3362-3367. 10.1021/bi952950g, 8639485.
68. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, et al. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996, 85:1135-1148. 10.1016/S0092-8674(00)81313-6, 8674119.
69. Bjorndal A, Deng H, Jansson M, Fiore JR, Colognesi C, Karlsson A, Albert J, Scarlatti G, Littman DR, Fenyo EM. Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype. J Virol 1997, 71:7478-7487. 192094, 9311827.
70. Cheng-Mayer C, Liu R, Landau NR, Stamatatos L. Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor. J Virol 1997, 71:1657-1661. 191226, 8995695.
71. Simmons G, Wilkinson D, Reeves JD, Dittmar MT, Beddows S, Weber J, Carnegie G, Desselberger U, Gray PW, Weiss RA, Clapham PR. Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. J Virol 1996, 70:8355-8360. 190923, 8970955.
72. Berger EA, Murphy PM, Farber JM. Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism and disease. Ann Rev Immunol 1999, 17:657-700.
73. Lee S, Tiffany HL, King L, Murphy PM, Golding H, Zaitseva MB. CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor. J Virol 2000, 74:6946-6952. 10.1128/JVI.74.15.6946-6952.2000, 112211, 10888633.
74. Sharron M, Pohlmann S, Price K, Lolis E, Tsang M, Kirchhoff F, Doms RW, Lee B. Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes. Blood 2000, 96:41-49.
75. O'Brien TR, Winkler C, Dean M, Nelson JA, Carrington M, Michael NL, White GC. HIV-1 infection in a man homozygous for CCR5 delta 32. Lancet 1997, 349:1219. 10.1016/S0140-6736(97)24017-1, 9130945.
76. Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996, 382:722-725. 10.1038/382722a0, 8751444.
77. Gorry PR, Zhang C, Wu S, Kunstman K, Trachtenberg E, Phair J, Wolinsky S, Gabuzda D. Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Delta 32 allele. Lancet 2002, 359:1832-1834. 10.1016/S0140-6736(02)08681-6, 12044382.
78. Michael NL, Nelson JA, KewalRamani VN, Chang G, O'Brien SJ, Mascola JR, Volsky B, Louder M, White GC, Littman DR, et al. Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32. Journal of virology 1998, 72:6040-6047. 110409, 9621067.
79. Rowe PM. CKR-5 deletion heterozygotes progress slower to AIDS. Lancet 1996, 348:947. 10.1016/S0140-6736(05)65339-1, 8843818.
80. Karlsson I, Grivel JC, Chen SS, Karlsson A, Albert J, Fenyo EM, Margolis LB. Differential pathogenesis of primary CCR5-using human immunodeficiency virus type 1 isolates in ex vivo human lymphoid tissue. Journal of virology 2005, 79:11151-11160. 10.1128/JVI.79.17.11151-11160.2005, 1193585, 16103166.
81. Goodenow MM, Collman RG. HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypes. J Leukoc Biol 2006, 80:965-972. 10.1189/jlb.0306148, 16923919.
82. Glushakova S, Yi Y, Grivel JC, Singh A, Schols D, De Clercq E, Collman RG, Margolis L. Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo. J Clin Invest 1999, 104:R7-R11. 10.1172/JCI7403, 408546, 10487781.
83. Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci U S A 1997, 94:1925-1930. 10.1073/pnas.94.5.1925, 20019, 9050881.
84. Gondois-Rey F, Grivel JC, Biancotto A, Pion M, Vigne R, Margolis LB, Hirsch I. Segregation of R5 and X4 HIV-1 variants to memory T cell subsets differentially expressing CD62L in ex vivo infected human lymphoid tissue. Aids 2002, 16:1245-1249. 10.1097/00002030-200206140-00006, 12045489.
85. Grivel J-C, Margolis LB. CCR5- and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue. Nature Medicine 1999, 5:344-346. 10.1038/6565, 10086394.
86. Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman GJ, Nguyen PL, Khoruts A, Larson M, Haase AT, Douek DC. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004, 200:749-759. 10.1084/jem.20040874, 2211962, 15365096.
87. Guadalupe M, Reay E, Sankaran S, Prindiville T, Flamm J, McNeil A, Dandekar S. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. Journal of virology 2003, 77:11708-11717. 10.1128/JVI.77.21.11708-11717.2003, 229357, 14557656.
88. Lim SG, Condez A, Lee CA, Johnson MA, Elia C, Poulter LW. Loss of mucosal CD4 lymphocytes is an early feature of HIV infection. Clin Exp Immunol 1993, 92:448-454. 10.1111/j.1365-2249.1993.tb03419.x, 1554790, 8099858.
89. Ullrich R, Zeitz M, Heise W, L'Age M, Ziegler K, Bergs C, Riecken EO. Mucosal atrophy is associated with loss of activated T cells in the duodenal mucosa of human immunodeficiency virus (HIV)-infected patients. Digestion 1990, 46(Suppl 2):302-307. 10.1159/000200401, 2262063.
90. Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P. HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. Aids 2007, 21:1263-1272. 10.1097/QAD.0b013e3281864667, 17545702.
91. Haaland RE, Hawkins PA, Salazar-Gonzalez J, Johnson A, Tichacek A, Karita E, Manigart O, Mulenga J, Keele BF, Shaw GM, et al. Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1. PLoS Pathog 2009, 5:e1000274. 10.1371/journal.ppat.1000274, 2621345, 19165325.
92. O'Connor DM. A tissue basis for colposcopic findings. Obstet Gynecol Clin North Am 2008, 35:565-582. viii, 10.1016/j.ogc.2008.09.009, 19061817.
93. Pudney J, Quayle AJ, Anderson DJ. Immunological Microenvironments in the Human Vagina and Cervix: Mediators of Cellular Immunity Are Concentrated in the Cervical Transformation Zone. Biol Reprod 2005,
94. Haase AT. Targeting early infection to prevent HIV-1 mucosal transmission. Nature 2010, 464:217-223. 10.1038/nature08757, 20220840.
95. Miller CJ, Shattock RJ. Target cells in vaginal HIV transmission. Microbes Infect 2003, 5:59-67. 10.1016/S1286-4579(02)00056-4, 12593974.
96. Kell PD, Barton SE, Edmonds DK, Boag FC. HIV infection in a patient with Meyer-Rokitansky-Kuster-Hauser syndrome. J R Soc Med 1992, 85:706-707. 1293736, 1474562.
97. Miller CJ, Alexander NJ, Vogel P, Anderson J, Marx PA. Mechanism of genital transmission of SIV: a hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques. J Med Primatol 1992, 21:64-68.
98. Anderson DJ, Politch JA, Nadolski AM, Blaskewicz CD, Pudney J, Mayer KH. Targeting Trojan Horse leukocytes for HIV prevention. AIDS 2010, 24:163-187. 10.1097/QAD.0b013e32833424c8, 20010071.
99. Argueso P, Spurr-Michaud S, Tisdale A, Gipson IK. Variation in the amount of T antigen and N-acetyllactosamine oligosaccharides in human cervical mucus secretions with the menstrual cycle. J Clin Endocrinol Metab 2002, 87:5641-5648. 10.1210/jc.2002-020766, 12466366.
100. Olmsted SS, Padgett JL, Yudin AI, Whaley KJ, Moench TR, Cone RA. Diffusion of macromolecules and virus-like particles in human cervical mucus. Biophys J 2001, 81:1930-1937. 10.1016/S0006-3495(01)75844-4, 1301668, 11566767.
101. Lai SK, Hida K, Shukair S, Wang YY, Figueiredo A, Cone R, Hope TJ, Hanes J. Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus. Journal of virology 2009, 83:11196-11200. 10.1128/JVI.01899-08, 2772788, 19692470.
102. Lai SK, O'Hanlon DE, Harrold S, Man ST, Wang YY, Cone R, Hanes J. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci U S A 2007, 104:1482-1487. 10.1073/pnas.0608611104, 1785284, 17244708.
103. Boukari H, Brichacek B, Stratton P, Mahoney SF, Lifson JD, Margolis L, Nossal R. Movements of HIV-virions in human cervical mucus. Biomacromolecules 2009, 10:2482-2488. 10.1021/bm900344q, 2768114, 19711976.
104. Agace WW, Amara A, Roberts AI, Pablos JL, Thelen S, Uguccioni M, Li XY, Marsal J, Arenzana-Seisdedos F, Delaunay T, et al. Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation. Curr Biol 2000, 10:325-328. 10.1016/S0960-9822(00)00380-8, 10744978.
105. Bomsel M, David V. Mucosal gatekeepers: selecting HIV viruses for early infection. Nat Med 2002, 8:114-116. 10.1038/nm0202-114, 11821891.
106. Furci L, Sironi F, Tolazzi M, Vassena L, Lusso P. Alpha-defensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4. Blood 2007, 109:2928-2935.
107. Wira CR, Grant-Tschudy KS, Crane-Godreau MA. Epithelial cells in the female reproductive tract: a central role as sentinels of immune protection. Am J Reprod Immunol 2005, 53:65-76. 10.1111/j.1600-0897.2004.00248.x, 15790340.
108. Wira CR, Fahey JV, Sentman CL, Pioli PA, Shen L. Innate and adaptive immunity in female genital tract: cellular responses and interactions. Immunol Rev 2005, 206:306-335. 10.1111/j.0105-2896.2005.00287.x, 16048557.
109. Seidel A, Ye Y, de Armas LR, Soto M, Yarosh W, Marcsisin RA, Tran D, Selsted ME, Camerini D. Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms. PLoS One 2010, 5:e9737. 10.1371/journal.pone.0009737, 2840026, 20305815.
110. Sun L, Finnegan CM, Kish-Catalone T, Blumenthal R, Garzino-Demo P, La Terra Maggiore GM, Berrone S, Kleinman C, Wu Z, Abdelwahab S, et al. Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. Journal of virology 2005, 79:14318-14329. 10.1128/JVI.79.22.14318-14329.2005, 1280242, 16254366.
111. Feng Z, Dubyak GR, Lederman MM, Weinberg A. Cutting edge: human beta defensin 3--a novel antagonist of the HIV-1 coreceptor CXCR4. J Immunol 2006, 177:782-786.
112. Quinones-Mateu ME, Lederman MM, Feng Z, Chakraborty B, Weber J, Rangel HR, Marotta ML, Mirza M, Jiang B, Kiser P, et al. Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication. AIDS 2003, 17:F39-48. 10.1097/00002030-200311070-00001, 14571200.
113. Zegels G, Van Raemdonck GA, Coen EP, Tjalma WA, Van Ostade XW. Comprehensive proteomic analysis of human cervical-vaginal fluid using colposcopy samples. Proteome Sci 2009, 7:17. 10.1186/1477-5956-7-17, 2678104, 19374746.
114. Habte HH, de Beer C, Lotz ZE, Tyler MG, Schoeman L, Kahn D, Mall AS. The inhibition of the Human Immunodeficiency Virus type 1 activity by crude and purified human pregnancy plug mucus and mucins in an inhibition assay. Virol J 2008, 5:59. 10.1186/1743-422X-5-59, 2409310, 18489743.
115. Kwong PD, Wyatt R, Sattentau QJ, Sodroski J, Hendrickson WA. Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus. J Virol 2000, 74:1961-1972. 10.1128/JVI.74.4.1961-1972.2000, 111674, 10644369.
116. Moulard M, Lortat-Jacob H, Mondor I, Roca G, Wyatt R, Sodroski J, Zhao L, Olson W, Kwong PD, Sattentau QJ. Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120. J Virol 2000, 74:1948-1960. 10.1128/JVI.74.4.1948-1960.2000, 111673, 10644368.
117. Vives RR, Imberty A, Sattentau QJ, Lortat-Jacob H. Heparan sulfate targets the HIV-1 envelope glycoprotein gp120 coreceptor binding site. J Biol Chem 2005, 280:21353-21357. 10.1074/jbc.M500911200, 15797855.
118. Alfsen A, Yu H, Magerus-Chatinet A, Schmitt A, Bomsel M. HIV-1-infected blood mononuclear cells form an integrin- and agrin-dependent viral synapse to induce efficient HIV-1 transcytosis across epithelial cell monolayer. Mol Biol Cell 2005, 16:4267-4279. 10.1091/mbc.E05-03-0192, 1196336, 15975901.
119. Wira CR, Fahey JV. A new strategy to understand how HIV infects women: identification of a window of vulnerability during the menstrual cycle. AIDS 2008, 22:1909-1917. 10.1097/QAD.0b013e3283060ea4, 2647143, 18784454.
120. Yeaman GR, Howell AL, Weldon S, Demian DJ, Collins JE, O'Connell DM, Asin SN, Wira CR, Fanger MW. Human immunodeficiency virus receptor and coreceptor expression on human uterine epithelial cells: regulation of expression during the menstrual cycle and implications for human immunodeficiency virus infection. Immunology 2003, 109:137-146. 10.1046/j.1365-2567.2003.01623.x, 1782948, 12709027.
121. Heise C, Miller CJ, Lackner A, Dandekar S. Primary acute simian immunodeficiency virus infection of intestinal lymphoid tissue is associated with gastrointestinal dysfunction. J Infect Dis 1994, 169:1116-1120.
122. Phillips DM, Zacharopoulos VR, Tan X, Pearce-Pratt R. Mechanisms of sexual transmission of HIV: does HIV infect intact epithelia?. Trends Microbiol 1994, 2:454-458. 10.1016/0966-842X(94)90804-4, 7866704.
123. Norvell MK, Benrubi GI, Thompson RJ. Investigation of microtrauma after sexual intercourse. J Reprod Med 1984, 29:269-271.
124. Ganor Y, Zhou Z, Tudor D, Schmitt A, Vacher-Lavenu MC, Gibault L, Thiounn N, Tomasini J, Wolf JP, Bomsel M. Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates. Mucosal Immunol 2010,
125. Platt EJ, Kozak SL, Durnin JP, Hope TJ, Kabat D. Rapid dissociation of HIV-1 from cultured cells severely limits infectivity assays, causes the inactivation ascribed to entry inhibitors, and masks the inherently high level of infectivity of virions. J Virol 2010, 84:3106-3110. 10.1128/JVI.01958-09, 2826045, 20042508.
126. Zhang Z, Schuler T, Zupancic M, Wietgrefe S, Staskus KA, Reimann KA, Reinhart TA, Rogan M, Cavert W, Miller CJ, et al. Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells. Science 1999, 286:1353-1357. 10.1126/science.286.5443.1353, 10558989.
127. Grivel JC, Margolis L. Use of human tissue explants to study human infectious agents. Nat Protoc 2009, 4:256-269. 10.1038/nprot.2008.245, 19197269.
128. Saba E, Grivel JC, Vanpouille C, Brichacek B, Fitzgerald W, Margolis L, Lisco A. HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model. Mucosal Immunol 2010, 3:280-290. 10.1038/mi.2010.2, 20147895.
129. Yeaman GR, Asin S, Weldon S, Demian DJ, Collins JE, Gonzalez JL, Wira CR, Fanger MW, Howell AL. Chemokine receptor expression in the human ectocervix: implications for infection by the human immunodeficiency virus-type I. Immunology 2004, 113:524-533. 10.1111/j.1365-2567.2004.01990.x, 1782606, 15554931.
130. Patterson BK, Landay A, Andersson J, Brown C, Behbahani H, Jiyamapa D, Burki Z, Stanislawski D, Czerniewski MA, Garcia P. Repertoire of chemokine receptor expression in the female genital tract: implications for human immunodeficiency virus transmission. Am J Pathol 1998, 153:481-490. 1852974, 9708808.
131. McClure CP, Tighe PJ, Robins RA, Bansal D, Bowman CA, Kingston M, Ball JK. HIV coreceptor and chemokine ligand gene expression in the male urethra and female cervix. Aids 2005, 19:1257-1265. 10.1097/01.aids.0000180096.50393.96, 16052080.
132. Hladik F, Sakchalathorn P, Ballweber L, Lentz G, Fialkow M, Eschenbach D, McElrath MJ. Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1. Immunity 2007, 26:257-270. 10.1016/j.immuni.2007.01.007, 1885958, 17306567.
133. Hussain LA, Lehner T. Comparative investigation of Langerhans' cells and potential receptors for HIV in oral, genitourinary and rectal epithelia. Immunology 1995, 85:475-484. 1383923, 7558138.
134. Turville SG, Cameron PU, Handley A, Lin G, Pohlmann S, Doms RW, Cunningham AL. Diversity of receptors binding HIV on dendritic cell subsets. Nat Immunol 2002, 3:975-983. 10.1038/ni841, 12352970.
135. Zacharopoulos VR, Perotti ME, Phillips DM. A role for cell migration in the sexual transmission of HIV-1?. Curr Biol 1997, 7:534-537. 10.1016/S0960-9822(06)00225-9, 9210380.
136. Hladik F, McElrath MJ. Setting the stage: host invasion by HIV. Nat Rev Immunol 2008, 8:447-457. 10.1038/nri2302, 2587276, 18469831.
137. Spira AI, Marx PA, Patterson BK, Mahoney J, Koup RA, Wolinsky SM, Ho DD. Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J Exp Med 1996, 183:215-225. 10.1084/jem.183.1.215, 2192425, 8551225.
138. Jayakumar P, Berger I, Autschbach F, Weinstein M, Funke B, Verdin E, Goldsmith MA, Keppler OT. Tissue-resident macrophages are productively infected ex vivo by primary X4 isolates of human immunodeficiency virus type 1. Journal of virology 2005, 79:5220-5226. 10.1128/JVI.79.8.5220-5226.2005, 1069582, 15795306.
139. McCoombe SG, Short RV. Potential HIV-1 target cells in the human penis. AIDS 2006, 20:1491-1495. 10.1097/01.aids.0000237364.11123.98, 16847403.
140. Dinh MH, McRaven MD, Kelley Z, Penugonda S, Hope TJ. Keratinization of the adult male foreskin and implications for male circumcision. Aids 2010, 24:899-906. 10.1097/QAD.0b013e3283367779, 20098294.
141. Patterson BK, Landay A, Siegel JN, Flener Z, Pessis D, Chaviano A, Bailey RC. Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture. Am J Pathol 2002, 161:867-873. 1867269, 12213715.
142. Donoval BA, Landay AL, Moses S, Agot K, Ndinya-Achola JO, Nyagaya EA, MacLean I, Bailey RC. HIV-1 target cells in foreskins of African men with varying histories of sexually transmitted infections. Am J Clin Pathol 2006, 125:386-391.
143. McClure CP, Tighe PJ, Robins RA, Bansal D, Bowman CA, Kingston M, Ball JK. HIV coreceptor and chemokine ligand gene expression in the male urethra and female cervix. AIDS 2005, 19:1257-1265. 10.1097/01.aids.0000180096.50393.96, 16052080.
144. Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, et al. Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes. J Infect Dis 2010, 201:1155-1163. 10.1086/651274, 20214475.
145. Nazli A, Chan O, Dobson-Belaire WN, Ouellet M, Tremblay MJ, Gray-Owen SD, Arsenault AL, Kaushic C. Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation. PLoS Pathog 2010, 6:e1000852. 10.1371/journal.ppat.1000852, 2851733, 20386714.
146. Olsson J, Poles M, Spetz AL, Elliott J, Hultin L, Giorgi J, Andersson J, Anton P. Human immunodeficiency virus type 1 infection is associated with significant mucosal inflammation characterized by increased expression of CCR5, CXCR4, and beta-chemokines. J Infect Dis 2000, 182:1625-1635. 10.1086/317625, 11069233.
147. Poles MA, Elliott J, Taing P, Anton PA, Chen IS. A preponderance of CCR5(+) CXCR4(+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection. J Virol 2001, 75:8390-8399. 10.1128/JVI.75.18.8390-8399.2001, 115084, 11507184.
148. Brenchley JM, Price DA, Douek DC. HIV disease: fallout from a mucosal catastrophe?. Nat Immunol 2006, 7:235-239. 10.1038/ni1316, 16482171.
149. Bomsel M. Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier. Nat Med 1997, 3:42-47. 10.1038/nm0197-42, 8986739.
150. Shen R, Smythies LE, Clements RH, Novak L, Smith PD. Dendritic cells transmit HIV-1 through human small intestinal mucosa. J Leukoc Biol 2010, 87:663-670. 10.1189/jlb.0909605, 20007245.
151. Wolinsky SM, Wike CM, Korber BT, Hutto C, Parks WP, Rosenblum LL, Kunstman KJ, Furtado MR, Munoz JL. Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants. Science 1992, 255:1134-1137. 10.1126/science.1546316, 1546316.
152. Scarlatti G, Hodara V, Rossi P, Muggiasca L, Bucceri A, Albert J, Fenyo EM. Transmission of human immunodeficiency virus type 1 (HIV-1) from mother to child correlates with viral phenotype. Virology 1993, 197:624-629. 10.1006/viro.1993.1637, 8249285.
153. van't Wout AB, Kootstra NA, Mulder-Kampinga GA, Albrecht-van Lent N, Scherpbier HJ, Veenstra J, Boer K, Coutinho RA, Miedema F, Schuitemaker H. Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission. J Clin Invest 1994, 94:2060-2067. 10.1172/JCI117560, 294642, 7962552.
154. Scarlatti G, Tresoldi E, Bjorndal A, Fredriksson R, Colognesi C, Deng HK, Malnati MS, Plebani A, Siccardi AG, Littman DR, et al. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Nat Med 1997, 3:1259-1265. 10.1038/nm1197-1259, 9359702.
155. Matala E, Hahn T, Yedavalli VR, Ahmad N. Biological characterization of HIV type 1 envelope V3 regions from mothers and infants associated with perinatal transmission. AIDS Res Hum Retroviruses 2001, 17:1725-1735. 10.1089/08892220152741423, 11788024.
156. Fultz PN. Components of saliva inactivate human immunodeficiency virus. Lancet 1986, 2:1215. 10.1016/S0140-6736(86)92218-X, 2877344.
157. Malamud D, Davis C, Berthold P, Roth E, Friedman H. Human submandibular saliva aggregates HIV. AIDS Res Hum Retroviruses 1993, 9:633-637. 10.1089/aid.1993.9.633, 8396401.
158. Nagashunmugam T, Friedman HM, Davis C, Kennedy S, Goldstein LT, Malamud D. Human submandibular saliva specifically inhibits HIV type 1. AIDS Res Hum Retroviruses 1997, 13:371-376. 10.1089/aid.1997.13.371, 9075477.
159. McNeely TB, Dealy M, Dripps DJ, Orenstein JM, Eisenberg SP, Wahl SM. Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro. J Clin Invest 1995, 96:456-464. 10.1172/JCI118056, 185219, 7615818.
160. Weinberg A, Quinones-Mateu ME, Lederman MM. Role of human beta-defensins in HIV infection. Adv Dent Res 2006, 19:42-48. 10.1177/154407370601900109, 16672548.
161. Abel K, Pahar B, Van Rompay KK, Fritts L, Sin C, Schmidt K, Colon R, McChesney M, Marthas ML. Rapid virus dissemination in infant macaques after oral simian immunodeficiency virus exposure in the presence of local innate immune responses. Journal of virology 2006, 80:6357-6367. 10.1128/JVI.02240-05, 1488945, 16775324.
162. Meng G, Wei X, Wu X, Sellers MT, Decker JM, Moldoveanu Z, Orenstein JM, Graham MF, Kappes JC, Mestecky J, et al. Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells. Nat Med 2002, 8:150-156. 10.1038/nm0202-150, 11821899.
163. Salvatori F, Scarlatti G. HIV type 1 chemokine receptor usage in mother-to-child transmission. AIDS Res Hum Retroviruses 2001, 17:925-935. 10.1089/088922201750290041, 11461678.
164. Clevestig P, Maljkovic I, Casper C, Carlenor E, Lindgren S, Naver L, Bohlin AB, Fenyo EM, Leitner T, Ehrnst A. The X4 phenotype of HIV type 1 evolves from R5 in two children of mothers, carrying X4, and is not linked to transmission. AIDS Res Hum Retroviruses 2005, 21:371-378. 10.1089/aid.2005.21.371, 15929699.
165. Huang W, Eshleman SH, Toma J, Stawiski E, Whitcomb JM, Jackson JB, Guay L, Musoke P, Parkin N, Petropoulos CJ. Vertical transmission of X4-tropic and dual-tropic HIV-1 in five Ugandan mother-infant pairs. AIDS 2009, 23:1903-1908. 10.1097/QAD.0b013e32832f1802, 2764460, 19593079.
166. Fenyo EM. Viral phenotype and severity of HIV-1 infection: are children different from adults?. Aids 1993, 7:1673-1674. 10.1097/00002030-199312000-00020, 8286079.
167. Spijkerman IJ, Koot M, Prins M, Keet IP, van den Hoek AJ, Miedema F, Coutinho RA. Lower prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users compared with homosexual men. AIDS 1995, 9:1085-1092. 10.1097/00002030-199509000-00016, 8527083.
168. Schutten M, van Baalen CA, Guillon C, Huisman RC, Boers PH, Sintnicolaas K, Gruters RA, Osterhaus AD. Macrophage tropism of human immunodeficiency virus type 1 facilitates in vivo escape from cytotoxic T-lymphocyte pressure. J Virol 2001, 75:2706-2709. 10.1128/JVI.75.6.2706-2709.2001, 115895, 11222694.
169. Harouse JM, Buckner C, Gettie A, Fuller R, Bohm R, Blanchard J, Cheng-Mayer C. CD8+ T cell-mediated CXC chemokine receptor 4-simian/human immunodeficiency virus suppression in dually infected rhesus macaques. Proc Natl Acad Sci U S A 2003, 100:10977-10982. 10.1073/pnas.1933268100, 196912, 12963814.
170. David SA, Smith MS, Lopez GJ, Adany I, Mukherjee S, Buch S, Goodenow MM, Narayan O. Selective transmission of R5-tropic HIV type 1 from dendritic cells to resting CD4+ T cells. AIDS Res Hum Retroviruses 2001, 17:59-68. 10.1089/088922201750056799, 11177384.
171. Ito Y, Grivel JC, Chen S, Kiselyeva Y, Reichelderfer P, Margolis L. CXCR4-tropic HIV-1 suppresses replication of CCR5-tropic HIV-1 in human lymphoid tissue by selective induction of CC-chemokines. J Infect Dis 2004, 189:506-514. 10.1086/381153, 14745709.
172. Lusso P, Earl PL, Sironi F, Santoro F, Ripamonti C, Scarlatti G, Longhi R, Berger EA, Burastero SE. Cryptic nature of a conserved, CD4-inducible V3 loop neutralization epitope in the native envelope glycoprotein oligomer of CCR5-restricted, but not CXCR4-using, primary human immunodeficiency virus type 1 strains. J Virol 2005, 79:6957-6968. 10.1128/JVI.79.11.6957-6968.2005, 1112133, 15890935.
173. Pastore C, Ramos A, Mosier DE. Intrinsic obstacles to human immunodeficiency virus type 1 coreceptor switching. J Virol 2004, 78:7565-7574. 10.1128/JVI.78.14.7565-7574.2004, 434079, 15220431.
174. Kuhmann SE, Moore JP. The HIV-1 phenotype variants: deadly and deadlier. J VirEntry 2005, 1:4-16.
175. Tscherning C, Alaeus A, Fredriksson R, Bjorndal A, Deng H, Littman DR, Fenyo EM, Albert J. Differences in chemokine coreceptor usage between genetic subtypes of HIV-1. Virology 1998, 241:181-188. 10.1006/viro.1997.8980, 9499793.
176. Lee HY, Giorgi EE, Keele BF, Gaschen B, Athreya GS, Salazar-Gonzalez JF, Pham KT, Goepfert PA, Kilby JM, Saag MS, et al. Modeling sequence evolution in acute HIV-1 infection. J Theor Biol 2009, 261:341-360. 10.1016/j.jtbi.2009.07.038, 2760689, 19660475.
177. Keele BF, Giorgi EE, Salazar-Gonzalez JF, Decker JM, Pham KT, Salazar MG, Sun C, Grayson T, Wang S, Li H, et al. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:7552-7557. 10.1073/pnas.0802203105, 2387184, 18490657.
178. Keele BF. Identifying and characterizing recently transmitted viruses. Curr Opin HIV AIDS 2010, 5:327-334. 10.1097/COH.0b013e32833a0b9b, 20543609.
179. Li H, Bar KJ, Wang S, Decker JM, Chen Y, Sun C, Salazar-Gonzalez JF, Salazar MG, Learn GH, Morgan CJ, et al. High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men. PLoS Pathog 2010, 6:e1000890. 10.1371/journal.ppat.1000890, 2869329, 20485520.
180. Gupta P, Collins KB, Ratner D, Watkins S, Naus GJ, Landers DV, Patterson BK. Memory CD4(+) T cells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system. Journal of virology 2002, 76:9868-9876. 10.1128/JVI.76.19.9868-9876.2002, 136513, 12208964.
181. Peters PJ, Sullivan WM, Duenas-Decamp MJ, Bhattacharya J, Ankghuambom C, Brown R, Luzuriaga K, Bell J, Simmonds P, Ball J, Clapham PR. Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis. Journal of virology 2006, 80:6324-6332. 10.1128/JVI.02328-05, 1488974, 16775320.
182. Alexander M, Lynch R, Mulenga J, Allen S, Derdeyn CA, Hunter E. Donor and recipient envs from heterosexual human immunodeficiency virus subtype C transmission pairs require high receptor levels for entry. Journal of virology 2010, 84:4100-4104. 10.1128/JVI.02068-09, 2849512, 20147398.
183. Liu Y, Curlin ME, Diem K, Zhao H, Ghosh AK, Zhu H, Woodward AS, Maenza J, Stevens CE, Stekler J, et al. Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses. Virology 2008, 374:229-233. 10.1016/j.virol.2008.01.029, 2441482, 18314154.
184. Derdeyn CA, Decker JM, Bibollet-Ruche F, Mokili JL, Muldoon M, Denham SA, Heil ML, Kasolo F, Musonda R, Hahn BH, et al. Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission. Science 2004, 303:2019-2022. 10.1126/science.1093137, 15044802.
185. Doores KJ, Bonomelli C, Harvey DJ, Vasiljevic S, Dwek RA, Burton DR, Crispin M, Scanlan CN. Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens. Proceedings of the National Academy of Sciences of the United States of America 2010,
186. Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, Middel J, Cornelissen IL, Nottet HS, KewalRamani VN, Littman DR, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000, 100:587-597. 10.1016/S0092-8674(00)80694-7, 10721995.
187. Geijtenbeek TB, van Kooyk Y. DC-SIGN: a novel HIV receptor on DCs that mediates HIV-1 transmission. Curr Top Microbiol Immunol 2003, 276:31-54.
188. Muratori C, Bona R, Ruggiero E, D'Ettorre G, Vullo V, Andreotti M, Federico M. DC contact with HIV-1-infected cells leads to high levels of Env-mediated virion endocytosis coupled with enhanced HIV-1 Ag presentation. Eur J Immunol 2009, 39:404-416. 10.1002/eji.200838751, 19180463.
189. van der Vlist M, Geijtenbeek TB. Langerin functions as an antiviral receptor on Langerhans cells. Immunol Cell Biol 2010, 88:410-415. 10.1038/icb.2010.32, 20309013.
190. Fauci AS. New Concepts in HIV/AIDS Pathogenesis: Implications for Interventions. In Book New Concepts in HIV/AIDS Pathogenesis: Implications for Interventions (Editor ed.^eds.), vol. TUPL010. City; 2010.
191. Cicala C, Martinelli E, McNally JP, Goode DJ, Gopaul R, Hiatt J, Jelicic K, Kottilil S, Macleod K, O'Shea A, et al. The integrin {alpha}4{beta}7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1. Proceedings of the National Academy of Sciences of the United States of America 2009, 2780317, 19933330.
192. Brenchley JM, Douek DC. HIV infection and the gastrointestinal immune system. Mucosal Immunol 2008, 1:23-30. 10.1038/mi.2007.1, 2777614, 19079157.
193. Sagar M, Laeyendecker O, Lee S, Gamiel J, Wawer MJ, Gray RH, Serwadda D, Sewankambo NK, Shepherd JC, Toma J, et al. Selection of HIV variants with signature genotypic characteristics during heterosexual transmission. J Infect Dis 2009, 199:580-589. 10.1086/596557, 2755256, 19143562.
194. Margolis L, Shattock R. Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved?. Nat Rev Microbiol 2006, 4:312-317. 10.1038/nrmicro1387, 16541138.