Actin-based motility: WAVE regulatory complex structure reopens old SCARs

Current Biology

Volumn 21, Issue 2, 2011, Pages

  Davidson, Andrew J ^a   Insall, Robert H ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79251507630     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2010.12.001     Document Type: Short Survey

References (20)

1. R.H. Insall, and L.M. Machesky Actin dynamics at the leading edge: from simple machinery to complex networks Dev. Cell 17 2009 310 322
2. A. Steffen, K. Rottner, J. Ehinger, M. Innocenti, G. Scita, J. Wehland, and T.E. Stradal Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation EMBO J. 23 2004 749 759
3. P. Kunda, G. Craig, V. Dominguez, and B. Baum Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions Curr. Biol. 13 2003 1867 1875
4. Z. Chen, D. Borek, S.B. Padrick, T.S. Gomez, Z. Metagel, A. Ismail, J. Umetani, D.D. Billadeau, Z. Otwinowski, and M.K. Rosen Structure and control of the actin regulatory WAVE complex Nature 468 2010 533 538
5. L.M. Machesky, and R.H. Insall Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex Curr. Biol. 8 1998 1347 1356
6. K.J. Amann, and T.D. Pollard Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy Proc. Natl. Acad. Sci. USA 98 2001 15009 15013
7. A.S. Kim, L.T. Kakalis, N. Abdul-Manan, G.A. Liu, and M.K. Rosen Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein Nature 404 2000 151 158
8. L.M. Machesky, R.D. Mullins, H.N. Higgs, D.A. Kaiser, L. Blanchoin, R.C. May, M.E. Hall, and T.D. Pollard Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex Proc. Natl. Acad. Sci. USA 96 1999 3739 3744
9. S. Eden, R. Rohatgi, A.V. Podtelejnikov, M. Mann, and M.W. Kirschner Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck Nature 418 2002 790 793
10. A.M. Ismail, S.B. Padrick, B. Chen, J. Umetani, and M.K. Rosen The WAVE regulatory complex is inhibited. Nat Struct. Mol. Biol. 16 2009 561 563
11. K. Kobayashi, S. Kuroda, M. Fukata, T. Nakamura, T. Nagase, N. Nomura, Y. Matsuura, N. Yoshida-Kubomura, A. Iwamatsu, and K. Kaibuchi p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase J. Biol. Chem. 273 1998 291 295
12. A.M. Lebensohn, and M.W. Kirschner Activation of the WAVE complex by coincident signals controls actin assembly Mol. Cell 36 2009 512 524
13. S.L. Rogers, U. Wiedemann, N. Stuurman, and R.D. Vale Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J Cell Biol. 162 2003 1079 1088
14. A.Y. Pollitt, and R.H. Insall Abi mutants in Dictyostelium reveal specific roles for the SCAR/WAVE complex in cytokinesis Curr. Biol. 18 2008 203 210
15. A. Gautreau, H.Y. Ho, J. Li, H. Steen, S.P. Gygi, and M.W. Kirschner Purification and architecture of the ubiquitous Wave complex Proc. Natl. Acad. Sci. USA 101 2004 4379 4383
16. S.M. Pocha, and G.O. Cory WAVE2 is regulated by multiple phosphorylation events within its VCA domain. Cell Motil Cytoskeleton 66 2009 36 47
17. T. Oikawa, H. Yamaguchi, T. Itoh, M. Kato, T. Ijuin, D. Yamazaki, S. Suetsugu, and T. Takenawa PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia Nat. Cell Biol. 6 2004 420 426
18. R.H. Insall, and O.D. Weiner PIP3, PIP2, and cell movement-similar messages, different meanings? Dev. Cell 1 2001 743 747
19. D.M. Veltman, and R.H. Insall WASP family proteins: their evolution and its physiological implications Mol. Biol. Cell 21 2010 2880 2893
20. N. Ibarra, S.L. Blagg, F. Vazquez, and R.H. Insall Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways Curr. Biol. 16 2006 717 722