Cocrystal formation from solvent mixtures

Crystal Growth and Design

Volumn 10, Issue 7, 2010, Pages 3237-3241

  Rager, Timo ^a   Hilfiker, Rolf ^a  

^a SOLVIAS AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; CO-CRYSTAL FORMATION; CO-CRYSTALS; COCRYSTALLIZATION; SOLVENT MIXTURES;

AMIDES; MIXTURES; SUGARS;

SOLVENTS;

EID: 79251504903     PISSN: 15287483     EISSN: 15287505     Source Type: Journal    
DOI: 10.1021/cg100361y     Document Type: Article

References (22)

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22. This statement is based on the assumption that thermodynamic equilibrium was reached. However, although there is an inherent driving force in suspension equilibration experiments toward the state of lowest energy, it cannot be excluded that kinetically instead of thermodynamically controlled solid-state forms are recovered after limited equilibration times. The ultimate proof for thermodynamic instability of the cocrystal would be the transformation of the cocrystal into the solvate in the given solution.