Pregnancy in Cystic Fibrosis

Clinics in Chest Medicine

Volumn 32, Issue 1, 2011, Pages 111-120

  Mcardle, John R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Birth outcomes; Cystic fibrosis; Genetic screening; Pregnancy

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; CEPHALOSPORIN; COTRIMOXAZOLE; DORNASE ALFA; GENTAMICIN; MUCOLYTIC AGENT; PANCREAS ENZYME; PENICILLIN DERIVATIVE; RIFAMYCIN; TETRACYCLINE; TOBRAMYCIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; VANCOMYCIN;

CYSTIC FIBROSIS; DRUG SAFETY; FETUS OUTCOME; FORCED EXPIRATORY VOLUME; GENETIC COUNSELING; GENETIC SCREENING; HUMAN; LUNG FUNCTION; LUNG TRANSPLANTATION; MALE INFERTILITY; MALNUTRITION; MATERNAL MORTALITY; NONHUMAN; PREGNANCY; PREGNANCY DIABETES MELLITUS; PREGNANCY OUTCOME; PRIORITY JOURNAL; PUERPERIUM; REVIEW; SURVIVAL TIME; TOOTH DISCOLORATION; TREATMENT PLANNING;

CYSTIC FIBROSIS; DELIVERY, OBSTETRIC; DIABETES, GESTATIONAL; DRUG TOXICITY; FEMALE; FERTILITY; FORCED EXPIRATORY VOLUME; GENETIC TESTING; HUMANS; LUNG; LUNG TRANSPLANTATION; MALNUTRITION; MATERNAL MORTALITY; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; TERATOGENS;

EID: 79251491342     PISSN: 02725231     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccm.2010.10.005     Document Type: Review

References (51)

1. Hamosh A., FitzSimmons S.C., Macek M., et al. Comparison of the clinical manifestations of cystic fibrosis in black and white patients. J Pediatr 1998, 132(2):255-259.
2. Riordan J.R., Rommens J.M., Kerem B., et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 1989, 245(4922):1066-1073.
3. Curran D.R., McArdle J.R., Talwalkar J.S. Diabetes mellitus and bone disease in cystic fibrosis. Semin Respir Crit Care Med 2009, 30(5):514-530.
4. Cystic Fibrosis Foundation Patient Registry: Annual Data Report 2008 Available at:, Accessed May 19, 2010. http://www.cff.org/UploadedFiles/research/ClinicalResearch/2008-Patient-Registry-Report.pdf.
5. Kaplan E., Shwachman H., Perlmutter A.D., et al. Reproductive failure in males with cystic fibrosis. N Engl J Med 1968, 279(2):65-69.
6. Anguiano A., Oates R.D., Amos J.A., et al. Congenital bilateral absence of the vas deferens. A primarily genital form of cystic fibrosis. JAMA 1992, 267(13):1794-1797.
7. Holsclaw D.S. Cystic fibrosis and fertility. Br Med J 1969, 3(5666):356.
8. Popli K., Stewart J. Infertility and its management in men with cystic fibrosis: review of literature and clinical practices in the UK. Hum Fertil (Camb) 2007, 10(4):217-221.
9. Meniru G.I., Forman R.G., Craft I.L. Utility of percutaneous epididymal sperm aspiration in situations of unexpected obstructive azoospermia. Hum Reprod 1997, 12(5):1013-1014.
10. Hubert D., Patrat C., Guibert J., et al. Results of assisted reproductive technique in men with cystic fibrosis. Hum Reprod 2006, 21(5):1232-1236.
11. Sueblinvong V., Whittaker L.A. Fertility and pregnancy: common concerns of the aging cystic fibrosis population. Clin Chest Med 2007, 28(2):433-443.
12. Johannesson M., Landgren B.M., Csemiczky G., et al. Female patients with cystic fibrosis suffer from reproductive endocrinological disorders despite good clinical status. Hum Reprod 1998, 13(8):2092-2097.
13. Johannesson M., Bogdanovic N., Nordqvist A.C., et al. Cystic fibrosis mRNA expression in rat brain: cerebral cortex and medial preoptic area. Neuroreport 1997, 8(2):535-539.
14. Oppenheimer E.A., Case A.L., Esterly J.R., et al. Cervical mucus in cystic fibrosis: a possible cause of infertility. Am J Obstet Gynecol 1970, 108(4):673-674.
15. Sutton K.A., Jungnickel M.K., Florman H.M. Of fertility, cystic fibrosis and the bicarbonate ion. Nat Cell Biol 2003, 5(10):857-859.
16. Edenborough F.P. Pregnancy in women with cystic fibrosis. Acta Obstet Gynecol Scand 2002, 81(8):689-692.
17. Edenborough F.P., Borgo G., Knoop C., et al. Guidelines for the management of pregnancy in women with cystic fibrosis. J Cyst Fibros 2008, 7(Suppl 1):S2-S32.
18. Lemna W.K., Feldman G.L., Kerem B., et al. Mutation analysis for heterozygote detection and the prenatal diagnosis of cystic fibrosis. N Engl J Med 1990, 322(5):291-296.
19. Simcox A.M., Hewison J., Duff A.J., et al. Decision-making about pregnancy for women with cystic fibrosis. Br J Health Psychol 2009, 14(Pt 2):323-342.
20. Saiman L., Marshall B.C., Mayer-Hamblett N., et al. Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial. JAMA 2003, 290(13):1749-1756.
21. Loebstein R., Addis A., Ho E., et al. Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled study. Antimicrob Agents Chemother 1998, 42(6):1336-1339.
22. Czeizel A.E., Rockenbauer M., Olsen J., et al. A teratological study of aminoglycoside antibiotic treatment during pregnancy. Scand J Infect Dis 2000, 32(3):309-313.
23. Geller D.E., Pitlick W.H., Nardella P.A., et al. Pharmacokinetics and bioavailability of aerosolized tobramycin in cystic fibrosis. Chest 2002, 122(1):219-226.
24. Fuchs H.J., Borowitz D.S., Christiansen D.H., et al. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group. N Engl J Med 1994, 331(10):637-642.
25. McMullen A.H., Pasta D.J., Frederick P.D., et al. Impact of pregnancy on women with cystic fibrosis. Chest 2006, 129(3):706-711.
26. Elkins M.R., Robinson M., Rose B.R., et al. A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med 2006, 354(3):229-240.
27. Siegel B., Siegel S. Pregnancy and delivery in a patient with cystic fibrosis of the pancreas. Obstet Gynecol 1960, 16:438-440.
28. Edenborough F.P., Stableforth D.E., Webb A.K., et al. Outcome of pregnancy in women with cystic fibrosis. Thorax 1995, 50(2):170-174.
29. Edenborough F.P., Mackenzie W.E., Stableforth D.E. The outcome of 72 pregnancies in 55 women with cystic fibrosis in the United Kingdom 1977-1996. BJOG 2000, 107(2):254-261.
30. Gillet D., de Braekeleer M., Bellis G., et al. Cystic fibrosis and pregnancy. Report from French data (1980-1999). BJOG 2002, 109(8):912-918.
31. Barak A., Dulitzki M., Efrati O., et al. Pregnancies and outcome in women with cystic fibrosis. Isr Med Assoc J 2005, 7(2):95-98.
32. Gilljam M., Antoniou M., Shin J., et al. Pregnancy in cystic fibrosis. Fetal and maternal outcome. Chest 2000, 118(1):85-91.
33. Boyd J.M., Mehta A., Murphy D.J. Fertility and pregnancy outcomes in men and women with cystic fibrosis in the United Kingdom. Hum Reprod 2004, 19(10):2238-2243.
34. Goss C.H., Rubenfeld G.D., Otto K., et al. The effect of pregnancy on survival in women with cystic fibrosis. Chest 2003, 124(4):1460-1468.
35. Ødegaard I., Stray-Pedersen B., Hallberg K., et al. Maternal and fetal morbidity in pregnancies of Norwegian and Swedish women with cystic fibrosis. Acta Obstet Gynecol Scand 2002, 81(8):698-705.
36. Cheng E.Y., Goss C.H., McKone E.F., et al. Aggressive prenatal care results in successful fetal outcomes in CF women. J Cyst Fibros 2006, 5(2):85-91.
37. Moran A., Hardin D., Rodman D., et al. Diagnosis, screening and management of cystic fibrosis related diabetes mellitus: a consensus conference report. Diabetes Res Clin Pract 1999, 45(1):61-73.
38. Kapoor N., Sankaran S., Hyer S., et al. Diabetes in pregnancy: a review of current evidence. Curr Opin Obstet Gynecol 2007, 19(6):586-590.
39. Metzger B.E., Lowe L.P., Dyer A.R., et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008, 358(19):1991-2002.
40. Dodd J.M., Crowther C.A., Antoniou G., et al. Screening for gestational diabetes: the effect of varying blood glucose definitions in the prediction of adverse maternal and infant health outcomes. Aust N Z J Obstet Gynaecol 2007, 47(4):307-312.
41. Crowther C.A., Hiller J.E., Moss J.R., et al. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med 2005, 352(24):2477-2486.
42. Hardin D.S., Rice J., Cohen R.C., et al. The metabolic effects of pregnancy in cystic fibrosis. Obstet Gynecol 2005, 106(2):367-375.
43. Thorpe-Beeston J.G. Contraception and pregnancy in cystic fibrosis. J R Soc Med 2009, 102(Suppl 1):3-10.
44. Hilman B.C., Aitken M.L., Constantinescu M. Pregnancy in patients with cystic fibrosis. Clin Obstet Gynecol 1996, 39(1):70-86.
45. Kotloff R.M., FitzSimmons S.C., Fiel S.B. Fertility and pregnancy in patients with cystic fibrosis. Clin Chest Med 1992, 13(4):623-635.
46. Budev M.M., Arroliga A.C., Emery S. Exacerbation of underlying pulmonary disease in pregnancy. Crit Care Med 2005, 33(Suppl 10):S313-S318.
47. Morton J., Glanville A.R. Lung transplantation in patients with cystic fibrosis. Semin Respir Crit Care Med 2009, 30(5):559-568.
48. Meachery G., De Soyza A., Nicholson A., et al. Outcomes of lung transplantation for cystic fibrosis in a large UK cohort. Thorax 2008, 63(8):725-731.
49. Gyi K.M., Hodson M.E., Yacoub M.Y. Pregnancy in cystic fibrosis lung transplant recipients: case series and review. J Cyst Fibros 2006, 5(3):171-175.
50. Armenti V.T., Radomski J.S., Moritz M., et al. Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. Clin Transpl 2004, 103-114.
51. Cleary B.J., Källén B. Early pregnancy azathioprine use and pregnancy outcome. Birth Defects Res A Clin Mol Teratol 2009, 85:647-654.