Clomifene citrate and intrauterine insemination as first-line treatments for unexplained infertility: Are they cost-effective?

Human Reproduction

Volumn 26, Issue 2, 2011, Pages 369-375

  Wordsworth, S ^a   Buchanan, J ^a   Mollison, J ^b   Harrild, K ^b   Robertson, L ^c   Tay, C ^d   Harrold, A ^e   McQueen, D ^f   Lyall, H ^g   Johnston, L ^b   Burrage, J ^f   Grossett, S ^d   Walton, H ^g   Lynch, J ^g   Johnstone, A ^d   Kini, S ^d   Raja, A ^d   Templeton, A ^b   Bhattacharya, S ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e NINEWELLS HOSPITAL   (United Kingdom)

^f NHS FORTH VALLEY   (United Kingdom)

^g GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

clomifene citrate; cost effectiveness; expectant management; intrauterine insemination; unexplained infertility

Indexed keywords

CLOMIFENE CITRATE;

ADULT; ARTICLE; BIRTH RATE; CALCULATION; CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; ECONOMIC EVALUATION; FEMALE; FEMALE INFERTILITY; HUMAN; INTRAUTERINE INSEMINATION; MAJOR CLINICAL STUDY; MONEY; MULTICENTER STUDY; OUTCOME ASSESSMENT; TREATMENT OUTCOME; UNITED KINGDOM;

EID: 79251489423     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/deq315     Document Type: Article

References (15)

1. Bhattacharya S, Harrild K, Mollison J, Wordsworth S, Tay C, Harrold A, McQueen D, Lyall H, Johnston L, Burrage J et al. Clomifene citrate or unstimulated intrauterine insemination compared with expectant management for unexplained infertility: pragmatic randomised controlled trial. Br Med J 2008;337:a716.
2. Claxton K. The irrelevance of inference: a decision-making approach to the stochastic evaluation of health care technologies. J Health Econ 1999;18:341-364.
3. Curtis L. Unit Costs of Health and Social Care 2008: Personal Social Services Research Unit. University of Kent, 2008. Daya. Cost-effective, evidence-based infertility care. Curr Opin Obstet Gynecol 2000;12:227-231.
4. Drummond MF, Sculpher M, Torrance G, O'Brien B, Stoddart G. Methods for the Economic Evaluation of Health Care Programmes. Oxford; New York: Oxford University Press, 2005.
5. Fenwick E, Claxton K, Sculpher M. Representing uncertainty: the role of cost-effectiveness acceptability curves. Health Econ 2001;10: 779-787.
6. Fenwick E, Marshall D, Levy A, Nichol G. Using and interpreting cost- effectiveness acceptability curves: an example using data from a trial of management strategies for atrial fibrillation. BMC Health Serv Res 2006;6:52.
7. Guzick D, Sullivan M, Adamson GD, Cedars M, Falk R, Peterson E, Steinkampf M. Efficacy of treatment for unexplained infertility. Fertil Steril 1998;70:207-213.
8. HM Treasury. Basis for setting the discount rate for calculating cash equivalent transfer values payable by public service pension schemes, 2008.
9. Hughes E. The effectiveness of ovulation induction and intrauterine insemination in the treatment of persistent infertility: a meta-analysis. Hum Reprod 1997;12:1865-1872.
10. ISD Scotland. Scottish Health Service Costs Book. ISD Publications, 2006.
11. NICE. Fertility: Assessment and Treatment for People with Fertility Problems. National Collaborating Centre for Women's and Children's Health, 2004.
12. Pashayan N, Lyratzopoulos G, Mathur R. Cost-effectiveness of primary offer of IVF vs. primary offer of IUI followed by IVF (for IUI failures) in couples with unexplained or mild male factor subfertility. BMC Health Serv Res 2006;6:80.
13. Practice Committee of the American Society for Reproductive Medicine. Effectiveness and treatment for unexplained infertility. Fertil Steril 2006; 86:S1111.
14. Steures P, van der Steeg JW, Hompes PGA, Habbema JDF, Eijkemans MJC, Broekmans FJ, Verhoeve HR, Bossuyt PMM, van der Veen F, Mol BWJ. Intrauterine insemination with controlled ovarian hyperstimulation versus expectant management for couples with unexplained subfertility and an intermediate prognosis: a randomised clinical trial. Lancet 2006;368(9531):216-221.
15. Templeton A. Infertility-epidemiology, aetiology, and effective management. Health Bull Edinb 1995;53:294-298.