Biological safety of human skin-derived stem cells after long-term in vitro culture

Journal of Tissue Engineering and Regenerative Medicine

Volumn 5, Issue 2, 2011, Pages 97-103

  Guan, Liping ^a   Yu, Jie ^a   Zhong, Ling ^a   Huang, Bing ^a   Luo, Ting ^a   Zhang, Min ^a   Lin, Shaochun ^a   Li, Weihua ^a   Ge, Jian ^a   Chen, Xigu ^a   Liu, Qian ^a   Zeng, Mei Zhen ^a   Song, Xinming ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Biological safety; Human skin mesenchymal stem cells; Karyotype; Major histocompatibility complex

Indexed keywords

CELL MEMBRANES; FLOW CYTOMETRY; MAMMALS; PROTEINS; STEM CELLS;

BIOLOGICAL SAFETY; HUMAN SKIN; HUMAN SKIN MESENCHYMAL STEM CELL; IN-VITRO; MAJOR HISTOCOMPATIBILITY COMPLEX; MESENCHYMAL STEM CELL; PROTEIN EXPRESSIONS; STEM-CELL; TUMORIGENICITY; VITRO CULTURE;

CELL CULTURE;

5' NUCLEOTIDASE; CD19 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; ENDOGLIN; HLA ANTIGEN; HLA DR ANTIGEN; MESSENGER RNA; VIMENTIN;

ANTIGEN EXPRESSION; ARTICLE; BIOSAFETY; CARCINOGENESIS; CARCINOGENICITY; CONTROLLED STUDY; FLOW CYTOMETRY; HEMATOPOIETIC CELL; HISTOCOMPATIBILITY; HISTOCOMPATIBILITY COMPLEX; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KARYOTYPE; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; SKIN; STEM CELL; TISSUE CULTURE;

EID: 79251474942     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.290     Document Type: Article

References (17)

1. Basham TY, Merigan TG. 1983; Recombinant γ-interferon increase HLA-DR synthesis and expression. Immunology 130: 1492.
2. Bernardo ME, Zaffaroni N, Novara F, et al. 2007; Human bone marrow-derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms. Cancer Res 67(19): 9142-9149.
3. Bianco P, Riminucci M, Gronthos S, et al. 2001; Bone marrow stromal stem cells. Nature, biology and potential applications. Stem Cells 19(3): 180-192.
4. Cheng L, Lai MD. 2003; Aberrant crypt foci as microscopic precursors of colorectal cancer. World Gastroenterol 9(12): 2642-2649.
5. Choumerianou DM, Dimitriou H, Perdikogianni C, et al. 2008; Study of oncogenic transformation in ex vivo expanded mesenchymal cells, from paediatric bone marrow. Cell Prolif 41: 909-922.
6. Deans RJ, Moseley AB. 2000; Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol 28: 875-884.
7. Devine SM, Hofman R. 2000; Role of mesenchymal stem cells in hematopoietic stem cell transplantation. Curr Opin Hematol 7(6): 358-363.
8. Geisler JP, Goodheart MJ, Sood AK, et al. Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma. Cancer 98(10): 2199-2206.
9. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. 2002; Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418: 41-49.
10. Kim J, Kang JW, Park JH, et al. 2009; Biological characterization of long-term cultured human mesenchymal stem cells. Arch Pharm Res 32(1): 117-126.
11. Kircher B, Stevanovic S, Urbanek I, et al. 2002; Induction of HA-I specific cytotoxic T-cell clones parallels the therapeutic effect of donor Iymphocyte infusion. Br J Haematol 117: 935-939.
12. Krause DS. 2002; Plasticity of marrow-derived stem cells. Gene Ther 9: 754-758.
13. Pittenger MF, Biackay AM, Jaiswal SC, et al. 1999; Multilineage potential of adult human mesenchymal stem cells. Science 284(5411): 143-148.
14. Pujol-Borell R, Todd I, Doshi M, et al. 1987; HLA class II induction in human islet cells by γ-interferon plus tumor necrosis factor or lymphotoxin. Nature 326: 304.
15. Souwer Y, Chamuleau MED, Arjan A, et al. 2009; Detection of aberrant transcription of major histocompatibility complex classII antigen presentation genes in chronic lymphocytic leukaemiaides HLA-DOA mRNA as a prognostic factor for survival. Br J Haematol 145(3): 334-343.
16. Woodbury D, Schmarz EJ, Prockop DJ, et al. 2000; Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61(4): 364-370.
17. Wulf GG, Chapuy B, Trumper L. 2006; Mesenchymal stem cells from bone marrow. Phenotype, aspects of biology, and clinical perspectives. Med Klin (Munich) 101: 408-413.