Sodium thiosulfate-based treatment in calcific uremic arteriolopathy: A consecutive case series

Clinical Nephrology

Volumn 75, Issue 1, 2011, Pages 8-15

  Sood, A R ^a,b   Wazny, L D ^a,b   Raymond, C B ^a,b   Leung, K ^b   Komenda, P ^a,b   Reslerova, M ^a,b   Verrelli, M ^a,b   Rigatto, C ^a,b   Sood, M M ^a,b  

^a ST BONIFACE GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Calcific uremic arteriolopathy; Calciphylaxis; End stage renal disease; Sodium thiosulfate

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CINACALCET; PAMIDRONIC ACID; SEVELAMER; SODIUM THIOSULFATE;

ADULT; ANALGESIA; ARTICLE; CALCIFIC UREMIC ARTERIOLOPATHY; CALCINOSIS; CLINICAL ARTICLE; CLINICAL FEATURE; COMORBIDITY; COST OF ILLNESS; DIAGNOSTIC IMAGING; FEMALE; FOLLOW UP; HUMAN; KIDNEY FAILURE; MALE; METABOLIC ACIDOSIS; MORTALITY; NAUSEA; RISK FACTOR; TREATMENT DURATION; UREMIA; VOMITING; WOUND CARE;

ADULT; ARTERIAL OCCLUSIVE DISEASES; CALCIPHYLAXIS; FEMALE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MANITOBA; MIDDLE AGED; PAIN; PERITONEAL DIALYSIS; RETROSPECTIVE STUDIES; THIOSULFATES; TIME FACTORS; TREATMENT OUTCOME; UREMIA; WOUND HEALING;

EID: 79251472145     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: 10.2379/CNP75008     Document Type: Article

References (35)

1. Mazhar AR, Johnson RJ, Gillen D, Stivelman JC, Ryan MJ, Davis CL, Stehman-Breen CO. Risk factors and mortality associated with calciphylaxis in end-stage renal disease. Kid Int. 2001; 60: 324-332.
2. Fine A, Zacharias J. Calciphylaxis is usually non-ulcerating: Risk factors, outcome and therapy. Kid Int. 2002; 61: 2210-2217.
3. Weenig RH, Sewell LD, Davis MDP, McCarthy JT, Pittelkow MR. Calciphylaxis: Natural history, risk factor analysis, and outcome. J Am Acad Dermatol. 2007; 56: 569-579.
4. Cicone JS, Petronis JB, Embert CD, Spector DA. Successful treatment of calciphylaxis with intravenous sodium thiosulfate. Am J Kidney Dis. 2004; 43: 1104-1108.
5. Schlieper G, Brandenburg V, Ketteler M, Floege J. Sodium thiosulfate in the treatment of calcific uremic arteriolopathy. Nat Rev Nephrol. 2009; 5: 539-543.
6. Pasch A, Schaffner T, Huynh-Do U, Frey BM, Frey FJ, Farese S. Sodium thiosulfate prevents vascular calcifcations in uremic rats. KI. 2008; 74: 1444-1453.
7. O'Neill WC. Treatment of vascular calcification. KI. 2008; 74: 1376-1378.
8. Ackermann F, Levy A, Daugas E, Schartz N, Riaux A, Derancourt C et al. Sodium thiosulfate as first-line treatment for calciphylaxis. Arch Dermatol. 2007; 143: 1336-1337.
9. Araya CE, Fennell RS, Neilberger RE, Dharnidharka VR. Sodium thiosulfate treatment for calcific uremic arteriolopathy in children and young adults. Clin J Am Soc Nephrol. 2006; 1: 1161-1166.
10. Guerra G, Shah RC, Ross EA. Rapid resolution of calciphylaxis with intravenous sodium thiosulfate and continuous venovenous haemofiltration using low calcium replacement fluid: case report. Nephrol Dial Transplant. 2005; 20: 1260-1262.
11. Hayden MR, Kolb LG, Khanna R. Calciphylaxis and the cardiometabolic syndrome. J Cardiometab Syndr. 2006; 1: 76-79.
12. Meissner M, Bauer R, Beier C, Betz C, Wolter M, Kaufmann R et al. Sodium thiosulphate as a promising therapeutic option to treat calciphylaxis. Dermatology. 2006; 212: 373-376.
13. Subramaniam K, Wallace H, Sinniah R, Saker B. Complete resolution of recurrent calciphylaxis with long-term intravenous sodium thiosulfate. Australas J Dermatol. 2008; 49: 30-34.
14. Tokashiki K, Ishida A, Kouchi M, Ishihara S, Tomiyama N, Kohagura K et al. Successful management of critical limb ischemia with intravenous sodium thiosulfate in a chronic hemodialysis patient. Clin Nephrol. 2006; 66: 140-143.
15. Kalisiak M, Courtney M, Lin A, Brassard A. Calcific uremic arteriolopathy (calciphylaxis): successful treatment with sodium thiosulfate in spite of elevated serum phosphate. J Cutan Med Surg. 2009; 13 (Suppl): 29-34.
16. Bazari H, Jaff MR, Mannstadt M, Yan S. Case records of the Massachusetts General Hospital. Case 7-2007. A 59-year-old woman with diabetic renal disease and nonhealing skin ulcers. N Engl J Med. 2007; 356: 1049-1057.
17. Brucculeri M, Cheigh J, Bauer G, Serur D. Long-term intravenous sodium thiosulfate in the treatment of a patient with calciphylaxis. Semin Dial. 2005; 18: 431-434.
18. Kyritsis I, Gombou A, Griveas I et al. Combination of sodium thiosulphate, cinacalcet, and paricalcitol in the treatment of calciphylaxis with hyperparathyroidism. Int J Artif Organs. 2008; 31: 742-744.
19. Musso CG, Enz P, Vidal F et al. Oral sodium thiosulfate solution as a secondary preventive treatment for calciphylaxis in dialysis patients. Saudi J Kidney Dis Transpl. 2008; 19: 820-821.
20. Soni S, Leslie WD. Bone scan findings in metastatic calcification from calciphylaxis. Clin Nucl Med. 2008; 33: 502-504.
21. Mataic D, Bastani B. Intraperitoneal sodium thiosulfate for the treatment of calciphylaxis. Ren Fail. 2006; 28: 361-363.
22. Norris B, Vaysman V, Line BR. Bone scintigraphy of calciphylaxis: a syndrome of vascular calcification and skin necrosis. Clin Nucl Med. 2005; 30: 725-727.
23. Thang OH, Jaspars EH, ter Wee PM. Necrotizing mastitis caused by calciphylaxis. Nephrol Dial Transplant. 2006; 21: 2020-2021.
24. Tindni A, Gaurav K, Panda M. Non-healing painful ulcers in a patient with chronic kidney disease and role of sodium thiosulfate: a case report. Cases J. 2008; 23: 178.
25. Li JZ, Huen W. Images in clinical medicine. Calciphylaxis with arterial calcification. N Engl J Med. 2007; 357: 1326.
26. Barakzoy AS, Moss AH. Efficacy of the world health organization analgesic ladder to treat pain in end-stage renal disease. J Am Soc Nephrol. 2006; 17: 3198-3203.
27. Drug Topics Red Book. Montvale, NJ: Thomson Healthcare; 2007. p. 725-726.
28. American Regent, Inc. www.americanregent.com 1-800-645-1706 (personal communication April 2010).
29. Ahmed S, O'Neill KD, Hood AF, Evan AP, Moe SM. Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells. Am J Kidney Dis. 2001; 37: 1267-1276.
30. Bleyer AJ, Choi M, Igwemezie B, de la Torre E, White WL. Acase control study of proximal calciphylaxis. Am J Kidney Dis. 1998; 32: 376-383.
31. Angelis M, Wong LL, Myers SA, Wong LM. Calciphylaxis in patients on hemodialysis: a prevalence study. Surgery. 1997; 122: 1083-1090.
32. Coates T, Kirkland GS, Dymock RB, Murphy BF, Brealey JK, Mathew TH, Disney AP. Cutaneous necrosis from calcific uremic arteriolopathy. Am J Kidney Dis. 1998; 32: 384-391.
33. Rubinger D, Friedlaender MM, Silver J, Kopolovic Y, Czaczkes WJ, Popovtzer MM. Progressive vascular calcification with necrosis of extremities in hemodialysis patients: a possible role of iron overload. Am J Kidney Dis. 1986; 7: 125-129.
34. Ruggian JC, Maesaka JK, Fishbane S. Proximal calciphylaxis in four insulin-requiring diabetic hemodialysis patients. Am J Kidney Dis. 1996; 28: 409-414.
35. Albrecht J, Meves A, Bigby M. Case reports and case series from Lancet had significant impact on medical literature. J Clin Epidemiol. 2005; 58: 1227-1232.