Role of cholesterol in the development and progression of breast cancer

American Journal of Pathology

Volumn 178, Issue 1, 2011, Pages 402-412

  Llaverias, Gemma ^a   Danilo, Christiane ^a   Mercier, Isabelle ^a   Daumer, Kristin ^a   Capozza, Franco ^a   Williams, Terence M ^a   Sotgia, Federica ^a   Lisanti, Michael P ^a   Frank, Philippe G ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GROWTH; CELL PROLIFERATION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DIET; FEMALE; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

EID: 79251469405     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2010.11.005     Document Type: Article

References (61)

1. Key TJ, Verkasalo PK, Banks E: Epidemiology of breast cancer. Lancet Oncol 2001, 2:133-140
2. Kelsey JL: Breast cancer epidemiology: summary and future directions. Epidemiol Rev 1993, 15:256-263
3. Shimizu H, Ross RK, Bernstein L, Yatani R, Henderson BE, Mack TM: Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. Br J Cancer 1991, 63:963-966
4. Cowey S, Hardy RW: The metabolic syndrome: a high-risk state for cancer? Am J Pathol 2006, 169:1505-1522
5. McMillan DC, Sattar N, McArdle CS: ABC of obesity: obesity and cancer. BMJ 2006, 333:1109-1111
6. Cantafora A, Blotta I: Neutral lipids production, transport, utilization. Anticancer Res 1996, 16:1441-1449 (Pubitemid 26257813)
7. Tomiki Y, Suda S, Tanaka M, Okuzawa A, Matsuda M, Ishibiki Y, Sakamoto K, Kamano T, Tsurumaru M, Watanabe Y: Reduced low-density-lipoprotein cholesterol causing low serum cholesterol levels in gastrointestinal cancer: a case control study. J Exp Clin Cancer Res 2004, 23:233-240 (Pubitemid 38943554)
8. Vitols S, Norgren S, Juliusson G, Tatidis L, Luthman H: Multilevel regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in normal and leukemic cells. Blood 1994, 84:2689-2698
9. Tatidis L, Gruber A, Vitols S: Decreased feedback regulation of low density lipoprotein receptor activity by sterols in leukemic cells from patients with acute myelogenous leukemia. J Lipid Res 1997, 38:2436-2445 (Pubitemid 28028128)
10. Tatidis L, Vitols S, Gruber A, Paul C, Axelson M: Cholesterol catabolism in patients with acute myelogenous leukemia and hypocholesterolemia: suppressed levels of a circulating marker for bile acid synthesis. Cancer Lett 2001, 170:169-175
11. Chen Y, Hughes-Fulford M: Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2. Int J Cancer 2001, 91:41-45
12. Caruso MG, Notarnicola M, Cavallini A, Di Leo A: 3-Hydroxy-3- methylglutaryl coenzyme A reductase activity and low-density lipoprotein receptor expression in diffuse-type and intestinal-type human gastric cancer. J Gastroenterol 2002, 37:504-508
13. Tatidis L, Masquelier M, Vitols S: Elevated uptake of low density lipoprotein by drug resistant human leukemic cell lines. Biochem Pharmacol 2002, 63:2169-2180
14. Chang SJ, Hou MF, Tsai SM, Wu SH, Hou LA, Ma H, Shann TY, Wu SH, Tsai LY: The association between lipid profiles and breast cancer among Taiwanese women. Clin Chem Lab Med 2007, 45:1219-1223
15. Kucharska-Newton AM, Rosamond WD, Mink PJ, Alberg AJ, Shahar E, Folsom AR: HDL-cholesterol and incidence of breast cancer in the ARIC cohort study. Ann Epidemiol 2008, 18:671-677
16. Kim Y, Park SK, Han W, Kim DH, Hong YC, Ha EH, Ahn SH, Noh DY, Kang D, Yoo KY: Serum high-density lipoprotein cholesterol and breast cancer risk by menopausal status, body mass index, and hormonal receptor in Korea. Cancer Epidemiol Biomarkers Prev 2009, 18:508-515
17. Guy CT, Cardiff RD, Muller WJ: Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 1992, 12:954-961
18. Maglione JE, Moghanaki D, Young LJ, Manner CK, Ellies LG, Joseph SO, Nicholson B, Cardiff RD, MacLeod CL: Transgenic polyoma middle-T mice model premalignant mammary disease. Cancer Res 2001, 61:8298-8305 (Pubitemid 33091625)
19. Lin EY, Jones JG, Li P, Zhu L, Whitney KD, Muller WJ, Pollard JW: Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 2003, 163:2113-2126
20. Williams TM, Medina F, Badano I, Hazan RB, Hutchinson J, Muller WJ, Chopra NG, Scherer PE, Pestell RG, Lisanti MP: Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo: role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem 2004, 279:51630-51646
21. Williams TM, Cheung MW, Park DS, Razani B, Cohen AW, Muller WJ, Di Vizio D, Chopra NG, Pestell RG, Lisanti MP: Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Mol Biol Cell 2003, 14:1027-1042 (Pubitemid 36337450)
22. Abramoff MD, Magelhaes PJ, Ram SJ: Image processing with Image J. Biophotonics Int 2004, 11:36-42
23. Cardiff RD, Anver MR, Gusterson BA, Hennighausen L, Jensen RA, Merino MJ, Rehm S, Russo J, Tavassoli FA, Wakefield LM, Ward JM, Green JE: The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene 2000, 19:968-988
24. Williams TM, Sotgia F, Lee H, Hassan G, Di Vizio D, Bonuccelli G, Capozza F, Mercier I, Rui H, Pestell RG, Lisanti MP: Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells. Am J Pathol 2006, 169:1784-1801
25. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can.J. Biochem 1959, 37:911-917
26. Connor WE, Lin DS: Placental transfer of cholesterol-4-14C into rabbit and guinea pig fetus. J Lipid Res 1967, 8:558-564
27. Green MH, Dohner EL, Green JB: Influence of dietary fat and cholesterol on milk lipids and on cholesterol metabolism in the rat. J Nutr 1981, 111:276-286
28. Whatley BJ, Green JB, Green MH: Effect of dietary fat and cholesterol on milk composition, milk intake and cholesterol metabolism in the rabbit. J Nutr 1981, 111:432-441
29. Lapidus RG, Nass SJ, Davidson NE: The loss of estrogen and progesterone receptor gene expression in human breast cancer. J Mammary Gland Biol Neoplasia 1998, 3:85-94
30. Solomon KR, Pelton K, Boucher K, Joo J, Tully C, Zurakowski D, Schaffner CP, Kim J, Freeman MR: Ezetimibe is an inhibitor of tumor angiogenesis. Am J Pathol 2009, 174:1017-1026
31. Cowin PA, Anglesio M, Etemadmoghadam D, Bowtell DD: Profiling the cancer genome. Annu Rev Genomics Hum Genet 2010, 11:133-159
32. Schottenfeld D, Beebe-Dimmer JL: Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions. Annu Rev Public Health 2005, 26:37-60
33. Forman MR, Hursting SD, Umar A, Barrett JC: Nutrition and cancer prevention: a multidisciplinary perspective on human trials. Annu Rev Nutr 2004, 24:223-254 (Pubitemid 38938792)
34. Gordon T, Kannel WB: Predisposition to atherosclerosis in the head, heart, and legs: the Framingham study. JAMA 1972, 221:661-666
35. Kritchevsky SB, Kritchevsky D: Serum cholesterol and cancer risk: an epidemiologic perspective. Annu Rev Nutr 1992, 12:391-416
36. Iso H, Ikeda A, Inoue M, Sato S, Tsugane S: Serum cholesterol levels in relation to the incidence of cancer: the JPHC study cohorts. Int J Cancer 2009, 125:2679-2686
37. Tobert JA: Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov 2003, 2:517-526
38. Blais L, Desgagne A, LeLorier J: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and the risk of cancer: a nested casecontrol study. Arch Intern Med 2000, 160:2363-2368
39. Cauley JA, Zmuda JM, Lui LY, Hillier TA, Ness RB, Stone KL, Cummings SR, Bauer DC: Lipid-lowering drug use and breast cancer in older women: a prospective study. J Womens Health (Larchmt) 2003, 12:749-756
40. Graaf MR, Beiderbeck AB, Egberts AC, Richel DJ, Guchelaar HJ: The risk of cancer in users of statins. J Clin Oncol 2004, 22:2388-2394
41. Poynter JN, Gruber SB, Higgins PD, Almog R, Bonner JD, Rennert HS, Low M, Greenson JK, Rennert G: Statins and the risk of colorectal cancer. N Engl J Med 2005, 352:2184-2192
42. Liao JK: Isoprenoids as mediators of the biological effects of statins. J Clin Invest 2002, 110:285-288
43. Flint DJ, Travers MT, Barber MC, Binart N, Kelly PA: Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland. Am J Physiol Endocrinol Metab 2005, 288:E1179-E1187
44. Cleary MP, Grande JP, Maihle NJ: Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-alpha mice. Int J Obes Relat Metab Disord 2004, 28:956-962
45. Swyer G: The cholesterol content of normal and enlarged prostates. Cancer Res 1942, 2:372-375
46. Zhuang L, Kim J, Adam RM, Solomon KR, Freeman MR: Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest 2005, 115:959-968 (Pubitemid 40489400)
47. Fairbanks KP, Witte LD, Goodman DS: Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor. J Biol Chem 1984, 259:1546-1551
48. Witte LD, Fairbanks KP, Barbu V, Goodman DS: Studies on cell proliferation and mevalonic acid metabolism in cultured human fibroblasts. Ann NY Acad Sci 1985, 454:261-269
49. Oseni T, Patel R, Pyle J, Jordan VC: Selective estrogen receptor modulators and phytoestrogens. Planta Med 2008, 74:1656-1665
50. Liu B, Edgerton S, Yang X, Kim A, Ordonez-Ercan D, Mason T, Alvarez K, McKimmey C, Liu N, Thor A: Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention. Cancer Res 2005, 65:879-886 (Pubitemid 40216447)
51. Deeg MA, Bowen RF, Oram JF, Bierman EL: High density lipoproteins stimulate mitogen-activated protein kinases in human skin fibroblasts. Arterioscler Thromb Vasc Biol 1997, 17:1667-1674
52. Grewal T, de Diego I, Kirchhoff MF, Tebar F, Heeren J, Rinninger F, Enrich C: High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of Ras. J Biol Chem 2003, 278:16478-16481
53. Gratton JP, Lin MI, Yu J, Weiss ED, Jiang ZL, Fairchild TA, Iwakiri Y, Groszmann R, Claffey KP, Cheng YC, Sessa WC: Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell 2003, 4:31-39
54. Dvorak HF: Leaky tumor vessels: consequences for tumor stroma generation and for solid tumor therapy. Prog Clin Biol Res 1990, 354A:317-330
55. Yuhanna IS, Zhu Y, Cox BE, Hahner LD, Osborne-Lawrence S, Lu P, Marcel YL, Anderson RG, Mendelsohn ME, Hobbs HH, Shaul PW: High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nat Med 2001, 7:853-857
56. Tauber JP, Cheng J, Massoglia S, Gospodarowicz D: High density lipoproteins and the growth of vascular endothelial cells in serum-free medium. In Vitro 1981, 17:519-530
57. Jadeski LC, Lala PK: Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors. Am J Pathol 1999, 155:1381-1390
58. Orucevic A, Bechberger J, Green AM, Shapiro RA, Billiar TR, Lala PK: Nitric-oxide production by murine mammary adenocarcinoma cells promotes tumor-cell invasiveness. Int J Cancer 1999, 81:889-896
59. Butt AJ, Sutherland RL, Musgrove EA: Live or let die: oestrogen regulation of survival signalling in endocrine response. Breast Cancer Res 2007, 9:306
60. Gong M, Wilson M, Kelly T, Su W, Dressman J, Kincer J, Matveev SV, Guo L, Guerin T, Li XA, Zhu W, Uittenbogaard A, Smart EJ: HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI-dependent manner. J Clin Invest 2003, 111:1579-1587 (Pubitemid 38063291)
61. Brodeur MR, Brissette L, Falstrault L, Luangrath V, Moreau R: Scavenger receptor of class B expressed by osteoblastic cells are implicated in the uptake of cholesteryl ester and estradiol from LDL and HDL3. J Bone Miner Res 2008, 23:326-337