Effects of agmatine on hypoxic microglia and activity of nitric oxide synthase

Brain Research

Volumn 1373, Issue , 2011, Pages 48-54

  Ahn, Soo Kyung ^a   Hong, Samin ^a   Park, Yu Mi ^a   Lee, Won Taek ^a   Park, Kyung Ah ^a   Lee, Jong Eun ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Agmatine; Hypoxia; Microglia; Neuroprotection; Nitric oxide synthase

Indexed keywords

AGMATINE; CALCIUM BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1; NITRIC OXIDE SYNTHASE; NITRITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN HYPOXIA; CELL VIABILITY; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVITY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

AGMATINE; ANALYSIS OF VARIANCE; ANIMALS; CALCIUM-BINDING PROTEINS; CELL HYPOXIA; CELL LINE, TRANSFORMED; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INFARCTION, MIDDLE CEREBRAL ARTERY; L-LACTATE DEHYDROGENASE; MALE; MICE; MICROGLIA; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY;

MURINAE; RATTUS;

EID: 79151485524     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.12.002     Document Type: Article

References (49)

1. K. Abe, Y. Abe, and H. Saito Agmatine suppresses nitric oxide production in microglia Brain Res. 872 2000 141 148
2. T. Arimoto, and G. Bing Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration Neurobiol. Dis. 12 2003 35 45
3. M. Auguet, I. Viossat, J.G. Marin, and P.E. Chabrier Selective inhibition of inducible nitric oxide synthase by agmatine Jpn J. Pharmacol. 69 1995 285 287
4. R.B. Banati, J. Gehrmann, P. Schubert, and G.W. Kreutzberg Cytotoxicity of microglia Glia 7 1993 111 118
5. V. Bocchini, R. Mazzolla, R. Barluzzi, E. Blasi, P. Sick, and H. Kettenmann An immortalized cell line expresses properties of activated microglial cells J. Neurosci. Res. 31 1992 616 621
6. K.M. Boje, and P.K. Arora Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death Brain Res. 587 1992 250 256
7. C.C. Chao, S. Hu, L. Ehrlich, and P.K. Peterson Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors Brain Behav. Immun. 9 1995 355 365
8. G.H. Danton, and W.D. Dietrich Inflammatory mechanisms after ischemia and stroke J. Neuropathol. Exp. Neurol. 62 2003 127 136
9. Y. Feng, J.E. Piletz, and M.H. Leblanc Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats Pediatr. Res. 52 2002 606 611
10. E. Galea, S. Regunathan, V. Eliopoulos, D.L. Feinstein, and D.J. Reis Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine Biochem. J. 316 1996 247 249
11. G.M. Gilad, and V.H. Gilad Accelerated functional recovery and neuroprotection by agmatine after spinal cord ischemia in rats Neurosci. Lett. 296 2000 97 100
12. G.M. Gilad, K. Salame, J.M. Rabey, and V.H. GIlad Agmatine treatment is neuroprotective in rodent brain injury models Life Sci. 58 1996 41 46
13. D. Giulian Ameboid microglia as effectors of inflammation in the central nervous system J. Neurosci. Res. 18 1987 155 171
14. H.S. Han, Y. Qiao, M. Karabiyikoglu, R.G. Giffard, and M.A. Yenari Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation J. Neurosci. 22 2002 3921 3928
15. S. Hong, C.Y. Kim, J.E. Lee, and G.J. Seong Agmatine protects cultured retinal ganglion cells from tumor necrosis factor-alpha-induced apoptosis Life Sci. 84 2009 28 32
16. S. Hong, J.E. Lee, C.Y. Kim, and G.J. Seong Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line BMC Neurosci. 8 2007 81
17. C. Iadecola, F. Zhang, R. Casey, M. Nagayama, and M.E. Ross Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene J. Neurosci. 17 1997 9157 9164
18. C. Iadecola, F. Zhang, S. Xu, R. Casey, and M.E. Ross Inducible nitric oxide synthase gene expression in brain following cerebral ischemia J. Cereb. Blood Flow Metab. 15 1995 378 384
19. R. Jin, G. Yang, and G. Li Inflammatory mechanisms in ischemic stroke: role of inflammatory cells J. Leukoc. Biol. 87 2010 779 789
20. B. Kaminska, K. Gaweda-Walerych, and M. Zawadzka Molecular mechanisms of neuroprotective action of immunosuppressants-facts and hypotheses J. Cell. Mol. Med. 8 2004 45 58
21. M. Khan, C. Elango, M.A. Ansari, I. Singh, and A.K. Singh Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia J. Neurochem. 102 2007 365 377
22. J.H. Kim, Y.W. Lee, K.A. Park, W.T. Lee, and J.E. Lee Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia J. Cereb. Blood Flow Metab. 30 2010 943 949
23. J.H. Kim, M.A. Yenari, R.G. Giffard, S.W. Cho, K.A. Park, and J.E. Lee Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury Exp. Neurol. 189 2004 122 130
24. K. Kotil, U. Kuscuoglu, M. Kirali, H. Uzun, M. Akcetin, and T. Bilge Investigation of the dose-dependent neuroprotective effects of agmatine in experimental spinal cord injury: a prospective randomized and placebo-control trial J. Neurosurg. Spine 4 2006 392 399
25. S.C. Lee, W. Liu, D.W. Dickson, C.F. Brosnan, and J.W. Berman Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysacch6aride and IL-1 beta J. Immunol. 150 1993 2659 2667
26. W.T. Lee, S. Hong, S.H. Yoon, J.H. Kim, K.A. Park, G.J. Seong, and J.E. Lee Neuroprotective effects of agmatine on oxygen-glucose deprived primary-cultured astrocytes and nuclear translocation of nuclear factor-kappa B Brain Res. 1281 2009 64 70
27. Y. Li, R.S. Erzurumlu, C. Chen, S. Jhaveri, and S. Tonegawa Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice Cell 76 1994 427 437 (Pubitemid 24064165)
28. H.Y. Lin, C.C. Huang, and K.F. Chang Lipopolysaccharide preconditioning reduces neuroinflammation against hypoxic ischemia and provides long-term outcome of neuroprotection in neonatal rat Pediatr. Res. 66 2009 254 259
29. S. Love Oxidative stress in brain ischemia Brain Pathol. 9 1999 119 131
30. M. Minami, Y. Kuraishi, K. Yabuuchi, A. Yamazaki, and M. Satoh Induction of interleukin-1 beta mRNA in rat brain after transient forebrain ischemia J. Neurochem. 58 1992 390 392
31. G. Olmos, N. DeGregorio-Rocasolano, M. Paz Regalado, T. Gasull, M. Assumpcio Boronat, R. Trullas, A. Villarroel, J. Lerma, and J.A. Garcia-Sevilla Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor Br. J. Pharmacol. 127 1999 1317 1326
32. K. Ono, H. Suzuki, and M. Sawada Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model Neurosci. Lett. 473 2010 146 150
33. J.E. Piletz, D.N. Chikkala, and P. Ernsberger Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors J. Pharmacol. Exp. Ther. 272 1995 581 587
34. I.J. Reynolds Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptor J. Pharmacol. Exp. Ther. 255 1990 1001 1007
35. N.J. Rothwell, and J.K. Relton Involvement of cytokines in acute neurodegeneration in the CNS Neurosci. Biobehav. Rev. 17 1993 217 227
36. G. Stoll, S. Jander, and M. Schroeter Inflammation and glial responses in ischemic brain lesions Prog. Neurobiol. 56 1998 149 171
37. W.J. Streit, M.B. Graeber, and G.W. Kreutzberg Functional plasticity of microglia: a review Glia 1 1988 301 307
38. M.G. Vannucchi, E. Bizzoco, L. Corsani, M. Gianfriddo, F. Pedata, and M.S. Faussone-Pellegrini Relationships between neurons expressing neuronal nitric oxide synthase, degree of microglia activation and animal survival. A study in the rat cortex after transient ischemia Brain Res. 1132 2007 218 227
39. M.T. Viscomi, L. Latini, F. Florenzano, G. Bernardi, and M. Molinari Minocycline attenuates microglial activation but fails to mitigate degeneration in inferior olive and pontine nuclei after focal cerebellar lesion Cerebellum 7 2008 401 405
40. H. Wang, W. Li, S. Zhu, J. Li, J. D'Amore, M.F. Ward, H. Yang, R. Wu, W. Jahnen-Dechent, K.J. Tracey, P. Wang, and A.E. Sama Peripheral administration of fetuin-A attenuates early cerebral ischemic injury in rats J. Cereb. Blood Flow Metab. 30 2010 493 504
41. W.P. Wang, A.H. Iyo, J. Miguel-Hidalgo, S. Regunathan, and M.Y. Zhu Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons Brain Res. 1084 2006 210 216
42. B.L. Ya, C.Y. Li, L. Zhang, W. Wang, and L. Li Cornel iridoid glycoside inhibits inflammation and apoptosis in brains of rats with focal cerebral ischemia Neurochem. Res. 35 2010 773 781
43. K. Yamashita, Y. Kataoka, Y. Sakurai-Yamashita, K. Shigematsu, A. Himeno, M. Niwa, and K. Taniyama Involvement of glial endothelin/nitric oxide in delayed neuronal death of rat hippocampus after transient forebrain ischemia Cell. Mol. Neurobiol. 20 2000 541 551
44. M.Z. Yang, C.H. Mun, Y.J. Choi, J.H. Baik, K.A. Park, W.T. Lee, and J.E. Lee Agmatine inhibits matrix metalloproteinase-9 via endothelial nitric oxide synthase in cerebral endothelial cells Neurol. Res. 29 2007 749 754
45. X.C. Yang, and D.J. Reis Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neurons J. Pharmacol. Exp. Ther. 288 1999 544 549
46. C.G. Yu, A.E. Marcillo, C.A. Fairbanks, G.L. Wilcox, and R.P. Yezierski Agmatine improves locomotor function and reduces tissue damage following spinal cord injury NeuroReport 11 2000 3203 3207
47. F. Zhang, and C. Iadecola Temporal characteristics of the protective effect of aminoguanidine on cerebral ischemic damage Brain Res. 802 1998 104 110
48. M.Y. Zhu, J.E. Piletz, A. Halaris, and S. Regunathan Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells Cell. Mol. Neurobiol. 23 2003 865 872
49. M.Y. Zhu, W.P. Wang, and G. Bissette Neuroprotective effects of agmatine against cell damage caused by glucocorticoids in cultured rat hippocampal neurons Neuroscience 141 2006 2019 2027