Induction of oxidative DNA damage by mesalamine in the presence of copper: A potential mechanism for mesalamine anticancer activity

Toxicology

Volumn 280, Issue 3, 2011, Pages 71-76

  Zimmerman, Ryan P ^a   Jia, Zhenquan ^a,b   Zhu, Hong ^a,b   Vandjelovic, Nathan ^a   Misra, Hara P ^a   Wang, Jianmin ^c   Li, Yunbo ^a,b  

^a EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c Beijing Labsolutions Pharmaceuticals   (China)

Author keywords

Anticancer activity; Copper; DNA strand breaks; Mesalamine

Indexed keywords

BATHOCUPROINEDISULFONIC ACID; CATALASE; CHELATING AGENT; COPPER; HYDROGEN PEROXIDE; HYDROXYL RADICAL; MESALAZINE; OXYGEN; PLASMID DNA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DNA STRAND BREAKAGE; DRUG MECHANISM; ELECTRON SPIN RESONANCE; IN VITRO STUDY; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; COPPER; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HUMANS; MESALAMINE; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 79151484926     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.11.009     Document Type: Article

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