Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 670-675

  Kumar, Suresh ^a   Bawa, Sandhya ^a   Drabu, Sushma ^a   Gupta, Himanshu ^a   MacHwal, Lalit ^a   Kumar, Rajiv ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

2 chloro 8 methylquinoline amines; Antidepressant activity; MAO activity; Neurotoxicity

Indexed keywords

2 CHLORO 3 (CHLOROMETHYL) 8 METHYLQUINOLINE; 2 CHLORO 8 METHYLQUINOLINE AMINE DERIVATIVE; 2 CHLORO N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL]ANILINE; 3 CHLORO N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL] 4 FLUOROANILINE; 3 CHLORO N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL]ANILINE; 3,4 DICHLORO N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL]ANILINE; 4 BROMO N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL]ANILINE; 4 CHLORO N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL]ANILINE; 4 NITRO N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL]ANILINE; ALIPHATIC AMINE; AMINE; AROMATIC AMINE; CLOMIPRAMINE; CLORGYLINE; FLUOXETINE; MOCLOBEMIDE; N [(2 CHLORO 8 METHYLQUINOLIN 3 YL) METHYL] 4 FLUOROANILINE; N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL] 2 METHYLANILINE; N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL] 3 METHYLANILINE; N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL] 4 METHOXYANILINE; N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL] 4-METHYLANILINE; N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL]ANILINE; N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL]BUTAN 1 AMINE; N [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYL]CYCLOHEXAMINE; N BENZYL 1 (2 CHLORO 8 METHYLQUINOLIN 3 YL)METHANAMINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE; QUIPAZINE; SELEGILINE; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS NIGER; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FORCED SWIMMING TEST; IMMOBILIZATION; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MICROANALYSIS; MONASCUS; NEUROTOXICITY; NONHUMAN; PENICILLIUM CITRINUM; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ROTAROD TEST; SUBSTITUTION REACTION;

ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIFUNGAL AGENTS; ASPERGILLUS FLAVUS; ASPERGILLUS NIGER; ENZYME INHIBITORS; MOLECULAR STRUCTURE; MONASCUS; MONOAMINE OXIDASE; MOTOR ACTIVITY; PENICILLIUM; QUINOLINES; RATS; RATS, WISTAR; ROTAROD PERFORMANCE TEST; STEREOISOMERISM; STRESS, PSYCHOLOGICAL; STRUCTURE-ACTIVITY RELATIONSHIP; SWIMMING;

EID: 79151481939     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.12.002     Document Type: Article

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