Mesenchymal Stromal Cells Fail to Prevent Acute Graft-versus-Host Disease and Graft Rejection after Dog Leukocyte Antigen-Haploidentical Bone Marrow Transplantation

Biology of Blood and Marrow Transplantation

Volumn 17, Issue 2, 2011, Pages 214-225

  Mielcarek, Marco ^a,b   Storb, Rainer ^a,b   Georges, George E ^a,b   Golubev, Ludmila ^a   Nikitine, Alla ^a   Hwang, Billanna ^a   Nash, Richard A ^a,b   Torok Storb, Beverly ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Canine model; Hematopoietic cell transplantation; MSC, GVHD; Rejection

Indexed keywords

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DOG; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HISTOCOMPATIBILITY COMPLEX; LEUKOCYTE; MESENCHYME CELL; NONHUMAN; STROMA CELL;

ANIMALS; BONE MARROW TRANSPLANTATION; CELLS, CULTURED; CLONE CELLS; CYTOKINES; CYTOTOXICITY TESTS, IMMUNOLOGIC; DOGS; GENE EXPRESSION PROFILING; GRAFT REJECTION; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; IMMUNOSUPPRESSION; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; STROMAL CELLS; SURVIVAL ANALYSIS; TRANSPLANTATION, HOMOLOGOUS;

EID: 79151475166     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2010.08.015     Document Type: Article

References (39)

1. Bartholomew A., Sturgeon C., Siatskas M., et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002, 30:42-48.
2. Le Blanc K., Tammik L., Sundberg B., et al. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 2003, 57:11-20.
3. Krampera M., Glennie S., Dyson J., et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003, 101:3722-3729.
4. Sudres M., Norol F., Trenado A., et al. Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice. J Immunol 2006, 176:7761-7767.
5. Chung N.G., Jeong D.C., Park S.J., et al. Cotransplantation of marrow stromal cells may prevent lethal graft-versus-host disease in major histocompatibility complex-mismatched murine hematopoietic stem cell transplantation. Int J Hematol 2004, 80:370-376.
6. Tisato V., Naresh K., Girdlestone J., et al. Mesenchymal stem cells of cord blood origin are effective at preventing but not treating graft-versus-host disease. Leukemia 2007, 21:1992-1999.
7. Lazarus H.M., Koc O.N., Devine S.M., et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant 2005, 11:389-398.
8. in't Anker P.S., Noort W.A., Kruisselbrink A.B., et al. Nonexpanded primary lung and bone marrow-derived mesenchymal cells promote the engraftment of umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp Hematol 2003, 31:881-889.
9. Angelopoulou M., Novelli E., Grove J.E., et al. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Exp Hematol 2003, 31:413-420.
10. Le Blanc K., Samuelsson H., Gustafsson B., et al. Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells. Leukemia 2007, 21:1733-1738.
11. Lee S.T., Jang J.H., Cheong J.W., et al. Treatment of high-risk acute myelogenous leukaemia by myeloablative chemoradiotherapy followed by co-infusion of T cell-depleted haematopoietic stem cells and culture-expanded marrow mesenchymal stem cells from a related donor with one fully mismatched human leucocyte antigen haplotype. Br J Haematol 2002, 118:1128-1131.
12. Lee W.S., Suzuki Y., Graves S.S., Iwata M., Venkataraman G.M., Mielcarek M., Peterson L.J., Ikehara S., Torok-Storb B., Storb R. Canine bone marrow-derived mesenchymal stromal cells suppress allo-reactive lymphocyte proliferation in vitro but fail to enhance engraftment in canine bone marrow transplantation. Biology of Blood and Marrow Transplantation 2010, [Epub ahead of print].
13. Le Blanc K., Rasmusson I., Sundberg B., et al. Treatment of severe acute graft-versus-host disease with third-party haploidentical mesenchymal stem cells. Lancet 2004, 363:1439-1441.
14. Lazarus H.M., Haynesworth S.E., Gerson S.L., et al. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplant 1995, 16:557-564.
15. Koc O.N., Gerson S.L., Cooper B.W., et al. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 2000, 18:307-316.
16. Ringdén O., Uzunel M., Rasmusson I., et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006, 81:1390-1397.
17. Le Blanc K., Frassoni F., Ball L., et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008, 371:1579-1586.
18. Baron F., Lechanteur C., Willems E., et al. Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning. Biol Blood Marrow Transplant 2010 Jun, 16(6):838-847. Epub 2010 Jan 28.
19. Martin P.J., Uberti J.P., Soiffer R.J., et al. Prochymal improves response rates in patioents with steroid-refractory acute graft versus host disease (SR-GVHD) involving the liver and gut: results of a randomized, placebo-controlled, multicenter phase III trial in GVHD. Biol Blood Marrow Transplant 2010, 16(Suppl):41. [abstract].
20. Roecklein B.A., Torok-Storb B. Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes. Blood 1995, 85:997-1005.
21. Graf L., Iwata M., Torok-Storb B. Gene expression profiling of the functionally distinct human bone marrow stromal cell lines HS-5 and HS-27a. Blood 2002, 100:1509-1511. [letter].
22. Gartner S.M., Kaplan H.S. Long-term culture of human bone marrow cells. Proc Natl Acad Sci U S A 1980, 77:4756-4759.
23. Raff R.F., Storb R., Ladiges W.C., et al. Recognition of target cell determinants associated with DLA-D locus-encoded antigens by canine cytotoxic lymphocytes. Transplantation 1985, 40:323-328.
24. Burroughs L., Mielcarek M., Little M.-T., et al. Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral blood mononuclear cells in a canine transplantation model. Blood 2005, 106:4002-4008.
25. Wagner J.L., Burnett R.C., DeRose S.A., et al. Histocompatibility testing of dog families with highly polymorphic microsatellite markers. Transplantation 1996, 62:876-877.
26. Wagner J.L., Works J.D., Storb R. DLA-DRB1 and DLA-DQB1 histocompatibility typing by PCR-SSCP and sequencing. Tissue Antigens 1998, 52:397-401.
27. + cells in granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cells induce secretion of interleukin-6 and G-CSF by marrow stroma. Blood 1996, 87:574-580.
28. Mielcarek M., Georges G.E., Storb R. Denileukin difitoxin as prophylaxis against graft-versus-host disease in the canine hematopoietic cell transplantation model. Biol Blood Marrow Transplant 2006, 12:899-904.
29. Georges G.E., Storb R., Bruno B., et al. Engraftment of DLA-haploidentical marrow with ex vivo expanded, retrovirally transduced cytotoxic T lymphocytes. Blood 2001, 98:3447-3455.
30. n polymorphisms to determine the origin of blood cells after allogeneic canine marrow grafting. Transplantation 1994, 58:701-706.
31. Hilgendorf I., Weirich V., Zeng L., et al. Canine haematopoietic chimerism analyses by semiquantitative fluorescence detection of variable number of tandem repeat polymorphism. Vet Res Commun 2005, 29:103-110.
32. Bindslev L., Haack-Sorensen M., Bisgaard K., et al. Labelling of human mesenchymal stem cells with indium-111 for SPECT imaging: effect on cell proliferation and differentiation. Eur J Nucl Med Mol Imag 2006, 33:1171-1177.
33. Keating A. Mesenchymal stromal cells. Curr Opin Hematol 2006, 13:419-425.
34. Bernardo M.E., Locatelli F., Fibbe W.E. Mesenchymal stromal cells. Ann NY Acad Sci 2009, 1176:101-117.
35. Aggarwal S., Pittenger M.F. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005, 105:1815-1822.
36. Meisel R., Zibert A., Laryea M., et al. Human bone marrow stromal cells inhibit allogeneic T cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004, 103:4619-4621.
37. Rasmusson I., Ringden O., Sundberg B., et al. Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms. Exp Cell Res 2005, 305:33-41.
38. Gao J., Dennis J.E., Muzic R.F., et al. The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion. Cells Tissues Organs 2001, 169:12-20.
39. 111In oxine-labeled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction. Nucl Med Commun 2003, 24:1149-1154.