Perioperative reductions in circulating lymphocyte levels predict wound complications after excisional breast cancer surgery

Annals of Surgery

Volumn 253, Issue 2, 2011, Pages 360-364

  Hogan, Brian V ^a,c   Peter, Mark B ^a   Achuthan, Rajgopal ^a   Beaumont, Amy J ^a   Langlands, Fiona E ^a,c   Shakes, Sara ^b   Wood, Philip M D ^c   Shenoy, Hrishikesh G ^a   Orsi, Nicolas M ^c   Horgan, Kieran ^a   Carter, Clive R D ^b   Hughes, Thomas A ^c  

^a LEEDS GENERAL INFIRMARY   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

ADULT; AGED; ARTICLE; AXILLARY LYMPH NODE; BREAST CANCER; CANCER SURGERY; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DEBRIDEMENT; DIABETES MELLITUS; HUMAN; IMMUNE STATUS; LYMPH NODE METASTASIS; LYMPHOCYTE; MAJOR CLINICAL STUDY; MASTECTOMY; MONOCYTE; NEUTROPHIL; PRIORITY JOURNAL; PROSPECTIVE STUDY; SMOKING; SURGICAL INFECTION;

AGED; BREAST NEOPLASMS; FEMALE; HUMANS; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; MASTECTOMY; MASTECTOMY, SEGMENTAL; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; SURGICAL WOUND INFECTION;

EID: 79151474440     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e318207c139     Document Type: Article

References (39)

1. Lefebvre D, Penel N, Deberles MF, et al. [Incidence and surgical wound infection risk factors in breast cancer surgery]. Presse Med. 2000;29(35):1927-1932.
2. Witt A, Yavuz D, Walchetseder C, et al. Preoperative core needle biopsy as an independent risk factor for wound infection after breast surgery. Obstet Gynecol. 2003;101(4):745-750.
3. Vinton AL, Traverso LW, Jolly PC.Wound complications aftermodified radical mastectomy comparedwith tylectomywith axillary lymph node dissection. Am J Surg. 1991;161(5):584-588.
4. Lin KY, Johns FR, Gibson J, et al. An outcome study of breast reconstruction: presurgical identification of risk factors for complications. Ann Surg Oncol. 2001;8(7):586-591.
5. Ruvalcaba-Limon E, Robles-Vidal C, Poitevin-Chacon A, et al. Complications after breast cancer surgery in patients treated with concomitant preoperative chemoradiation: a case-control analysis. Breast Cancer Res Treat. 2006;95(2):147-152.
6. Huang J, Barbera L, Brouwers M, et al. Does delay in starting treatment affect the outcomes of radiotherapy? A systematic review. J Clin Oncol. 2003;21(3):555-563.
7. Hershman DL,Wang X,McBride R, et al. Delay of adjuvant chemotherapy initiation following breast cancer surgery among elderly women. Breast Cancer Res Treat. 2006;99(3):313-321.
8. Murthy BL, ThomsonCS, DodwellD, et al. Postoperativewound complications and systemic recurrence in breast cancer. Br J Cancer. 2007;97(9):1211-1217.
9. Goyal S, Khan AJ, Vicini F, et al. Factors associated with optimal cosmetic results at 36 months in patients treated with accelerated partial breast irradiation (APBI) on the American Society of Breast Surgeons (ASBrS) MammoSite Breast Brachytherapy Registry Trial. Ann Surg Oncol. 2009;16(9):2450-2458.
10. Coello R, Glenister H, Fereres J, et al. The cost of infection in surgical patients: a case-control study. J Hosp Infect. 1993;25(4):239-250.
11. Cunningham M, Bunn F, Handscomb K. Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery. Cochrane Database Syst Rev. 2006;2:CD005360.
12. National Audit Office UK. The Management and Control of Hospital Acquired Infection in Acute NHS Trusts in England. London, UK: Her Majesty's Stationery Office, 2000.
13. National Audit Office UK. Reducing Healthcare Associated Infections in Hospitals in England. London, UK: Her Majesty's Stationery Office, 2009.
14. Chen J, Gutkin Z, Bawnik J. Postoperative infections in breast surgery. J Hosp Infect. 1991;17(1):61-65.
15. Cruse PJ, Foord R. The epidemiology of wound infection. A 10-year prospective study of 62,939 wounds. Surg Clin North Am. 1980;60(1): 27-40.
16. Sorensen LT, Horby J, Friis E, et al. Smoking as a risk factor for wound healing and infection in breast cancer surgery. Eur J Surg Oncol. 2002;28(8): 815-820.
17. Platt R, Zaleznik DF, Hopkins CC, et al. Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery. N Engl J Med. 1990;322(3):153-160. (Pubitemid 20036388)
18. Gupta S, Koirala J, Khardori R, et al. Infections in diabetes mellitus and hyperglycemia. Infect Dis Clin North Am. 2007;21(3):617-638, vii.
19. Enderle MD, Pfohl M, Kellermann N, et al. Endothelial function, variables of fibrinolysis and coagulation in smokers and healthy controls. Haemostasis. 2000;30(3):149-158.
20. Rassias AJ, Givan AL,Marrin CA, et al. Insulin increases neutrophil count and phagocytic capacity after cardiac surgery. Anesth Analg. 2002;94(5):1113-1119.
21. Holt PG. Immune and inflammatory function in cigarette smokers. Thorax. 1987;42(4):241-249.
22. Weiskopf D,Weinberger B, Grubeck-Loebenstein B. The aging of the immune system. Transpl Int. 2009;22(11):1041-1050.
23. Redmond HP, Watson RW, Houghton T, et al. Immune function in patients undergoing open vs laparoscopic cholecystectomy. Arch Surg. 1994;129(12):1240- 1246.
24. SladeMS, Simmons RL, Yunis E, et al. Immunodepression after major surgery in normal patients. Surgery. 1975;78(3):363-372.
25. Moudgil GC, Pandya AR, Ludlow DJ. Influence of anaesthesia and surgery on neutrophil chemotaxis. Can Anaesth Soc J. 1981;28(3):232-238.
26. Welch WD. Halothane reversibly inhibits human neutrophil bacterial killing. Anesthesiology. 1981;55(6):650-654.
27. Frohlich D, Rothe G, Schwall B, et al. Effects of volatile anaesthetics on human neutrophil oxidative response to the bacterial peptide FMLP. Br J Anaesth. 1997;78(6):718-723.
28. Chen RM, Wu CH, Chang HC, et al. Propofol suppresses macrophage functions and modulates mitochondrial membrane potential and cellular adenosine triphosphate synthesis. Anesthesiology. 2003;98(5):1178-1185.
29. Wu GJ, Tai YT, Chen TL, et al. Propofol specifically inhibits mitochondrial membrane potential but not complex I NADH dehydrogenase activity, thus reducing cellular ATP biosynthesis and migration of macrophages. Ann N Y Acad Sci. 2005;1042:168-176.
30. Lennard TW, Shenton BK, Borzotta A, et al. The influence of surgical operations on components of the human immune system. Br J Surg. 1985;72(10):771-776.
31. Ogawa K, Hirai M, Katsube T, et al. Suppression of cellular immunity by surgical stress. Surgery. 2000;127(3):329-336.
32. GoldfarbY, Ben-Eliyahu S. Surgery as a risk factor for breast cancer recurrence and metastasis: mediating mechanisms and clinical prophylactic approaches. Breast Dis. 2006;26:99-114.
33. Sacerdote P. Opioids and the immune system. Palliat Med. 2006;20 (suppl 1):s9-s15.
34. Toft P, Lillevang ST, Tonnesen E, et al. Redistribution of lymphocytes following E. coli sepsis. Scand J Immunol. 1993;38(6):541-545.
35. Toft P, Svendsen P, Tonnesen E, et al. Redistribution of lymphocytes aftermajor surgical stress. Acta Anaesthesiol Scand. 1993;37(3):245-249.
36. Comans-Bitter WM, de Groot R, van den Beemd R, et al. Immunophenotyping of blood lymphocytes in childhood. Reference values for lymphocyte subpopulations. J Pediatr. 1997;130(3):388-393.
37. Wakefield CH, Carey PD, Foulds S, et al. Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. Br J Surg. 1993;80(2):205-209.
38. Duignan JP, Collins PB, Johnson AH, et al. The association of impaired neutrophil chemotaxis with postoperative surgical sepsis. Br J Surg. 1986;73(3):238-240.
39. Lapsley HM, Vogels R. Quality and cost impacts: prevention of postoperative clean wound infections. Int J Health Care Qual Assur Inc Leadersh Health Serv. 1998;11(6/7):222-231.