Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype

Journal of Virology

Volumn 85, Issue 4, 2011, Pages 1464-1472

  Heiss, Brian L ^a,b   Maximova, Olga A ^a   Pletnev, Alexander G ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 124A; MICRORNA 128A; MICRORNA 218; MICRORNA 9; MICRORNA LET 7C; STRUCTURAL PROTEIN; TICK BORNE ENCEPHALITIS VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; BRAIN TISSUE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DENGUE VIRUS 4; DNA MODIFICATION; FLAVIVIRUS; GENE EXPRESSION; GENE INSERTION; HAPLORHINI; HUMORAL IMMUNITY; MOUSE; NEUROPATHOLOGY; NEUROTROPISM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RHESUS MONKEY; STRUCTURAL GENE; TICK BORNE ENCEPHALITIS; TICK BORNE ENCEPHALITIS FLAVIVIRUS; VIRUS ATTENUATION; VIRUS GENOME; VIRUS REPLICATION; VIRUS VIRULENCE;

ANIMALS; ANTIBODIES, VIRAL; BRAIN; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CULICIDAE; DENGUE; DENGUE VIRUS; ENCEPHALITIS VIRUSES, TICK-BORNE; ENCEPHALITIS, TICK-BORNE; GENOME, VIRAL; HUMANS; MACACA MULATTA; MICE; MICRORNAS; MUTAGENESIS, INSERTIONAL; NEURONS; RATS; RATS, INBRED F344; RECOMBINANT FUSION PROTEINS; VACCINES, ATTENUATED; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRAL VACCINES; VIRUS REPLICATION;

FLAVIVIRUS; IXODIDA; JAPANESE ENCEPHALITIS VIRUS; MUS; TICK-BORNE ENCEPHALITIS VIRUS; TICK-BORNE ENCEPHALITIS VIRUS GROUP;

EID: 78951495607     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02091-10     Document Type: Article

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