The activity and hydrogen peroxide sensitivity of the peroxiredoxins from the parasitic nematode Haemonchus contortus

Molecular and Biochemical Parasitology

Volumn 176, Issue 1, 2011, Pages 17-24

  Hudson, Amanda L ^a   Sotirchos, Irene M ^a   Davey, Mary W ^b  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

Antioxidant activity; Glutathione system; Haemonchus contortus; Nematode; Peroxiredoxin; Thioredoxin system

Indexed keywords

DNA; FREE RADICAL; GLUTATHIONE; HYDROGEN PEROXIDE; PEROXIREDOXIN 1; PEROXIREDOXIN 2; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 2;

ANTIOXIDANT ACTIVITY; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DETOXIFICATION; EUKARYOTE; HAEMONCHUS CONTORTUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGENERATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANTIOXIDANTS; CAENORHABDITIS ELEGANS; ENZYME ACTIVATION; HAEMONCHUS; HERBICIDES; HYDROGEN PEROXIDE; KINETICS; MOLECULAR SEQUENCE DATA; OXIDANTS; OXIDATIVE STRESS; PARAQUAT; PEROXIREDOXINS; PHYLOGENY; SEQUENCE ALIGNMENT; THIOREDOXINS;

CAENORHABDITIS ELEGANS; EUKARYOTA; HAEMONCHUS CONTORTUS; MAMMALIA;

EID: 78951491178     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2010.11.006     Document Type: Article

References (44)

1. J.R. Pedrajas, A. Miranda-Vizuete, N. Javanmardy, J.A. Gustafsson, and G. Spyrou Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity J Biol Chem 275 2000 16296 16301
2. B. Hofmann, H.J. Hecht, and L. Flohe Peroxiredoxins Biol Chem 383 2002 347 364
3. H.Z. Chae, H.J. Kim, S.W. Kang, and S.G. Rhee Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin Diabetes Res Clin Pract 45 1999 101 112
4. R.B. Moore, M.V. Mankad, S.K. Shriver, V.N. Mankad, and G.A. Plishker Reconstitution of Ca(2+)-dependent K+ transport in erythrocyte membrane vesicles requires a cytoplasmic protein J Biol Chem 266 1991 18964 18968
5. Z.A. Wood, L.B. Poole, and P.A. Karplus Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling Science 300 2003 650 653
6. G.B. Henderson, A.H. Fairlamb, and A. Cerami Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei Mol Biochem Parasitol 24 1987 39 45
7. R.K. Mehlotra Antioxidant defense mechanisms in parasitic protozoa Crit Rev Microbiol 22 1996 295 314
8. G.M. Mkoji, J.M. Smith, and R.K. Prichard Antioxidant systems in Schistosoma mansoni: correlation between susceptibility to oxidant killing and the levels of scavengers of hydrogen peroxide and oxygen free radicals Int J Parasitol 18 1988 661 666
9. C. Nickel, M. Trujillo, S. Rahlfs, M. Deponte, R. Radi, and K. Becker Plasmodium falciparum 2-Cys peroxiredoxin reacts with plasmoredoxin and peroxynitrite Biol Chem 386 2005 1129 1136
10. W.A. Pryor, K.N. Houk, and C.S. Foote Free radical biology and medicine: it's a gas, man! Am J Physiol Regul Integr Comp Physiol 291 2006 R491 511
11. H.L. Callahan, R.K. Crouch, and E.R. James Helminth anti-oxidant enzymes: a protective mechanism against host oxidants? Parasitol Today 4 1988 218 225
12. S. Muller, E. Liebau, R.D. Walter, and R.L. Krauth-Siegel Thiol-based redox metabolism of protozoan parasites Trends Parasitol 19 2003 320 328
13. T. Jaeger, and L. Flohe The thiol-based redox networks of pathogens: unexploited targets in the search for new drugs Biofactors 27 2006 109 120
14. G. Salinas, M.E. Selkirk, C. Chalar, R.M. Maizels, and C. Fernandez Linked thioredoxin-glutathione systems in platyhelminths Trends Parasitol 20 2004 340 346
15. K. Kunchithapautham, B. Padmavathi, R.B. Narayanan, P. Kaliraj, and A.L. Scott Thioredoxin from Brugia malayi: defining a 16-kilodalton class of thioredoxins from nematodes Infect Immun 71 2003 4119 4126
16. I.M. Sotirchos, A.L. Hudson, J. Ellis, and M.W. Davey Thioredoxins of a parasitic nematode: comparison of the 16- and 12-kDA thioredoxins from Haemonchus contortus Free Radic Biol Med 44 2008 2026 2033
17. I.M. Sotirchos, A.L. Hudson, J. Ellis, and M.W. Davey A unique thioredoxin of the parasitic nematode Haemonchus contortus with glutaredoxin activity Free Radic Biol Med 46 2009 579 585
18. N.H. Bagnall, and A.C. Kotze cDNA cloning and expression patterns of a peroxiredoxin, a catalase and a glutathione peroxidase from Haemonchus contortus Parasitol Res 94 2004 283 289
19. A.L. Hudson, I.M. Sotirchos, and M.W. Davey Substrate specificity of the mitochondrial thioredoxin reductase of the parasitic nematode Haemonchus contortus Parasitol Res 107 2010 487 493
20. M. Sekiya, G. Mulcahy, and J.A. Irwin Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica FEBS Lett 580 2006 5016 5022
21. A. Holmgren Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide J Biol Chem 254 1979 9627 9632
22. A. Holmgren, and M. Bjornstedt Thioredoxin and thioredoxin reductase Methods Enzymol 252 1995 199 208
23. X.W. Wang, Y.C. Liou, B. Ho, and J.L Ding An evolutionarily conserved 16-kDa thioredoxin-related protein is an antioxidant which regulates the NF-kappaB signaling pathway Free Radic Biol Med 42 2007 247 259
24. C.E. James, and M.W. Davey A rapid colorimetric assay for the quantitation of the viability of free-living larvae of nematodes in vitro Parasitol Res 101 2007 975 980
25. A.A. Sayed, and D.L. Williams Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni J Biol Chem 279 2004 26159 26166
26. S. Bar-Noy, S.N. Gorlatov, and T.C. Stadtman Overexpression of wild type and SeCys/Cys mutant of human thioredoxin reductase in E. coli: the role of selenocysteine in the catalytic activity Free Radic Biol Med 30 2001 51 61
27. O. Rengby, L. Johansson, and L.A. Carlson Assessment of production conditions for efficient use of Escherichia coli in high-yield heterologous recombinant selenoprotein synthesis Appl Environ Microbiol 70 2004 5159 5167
28. M. Feelisch, K. Schonafinger, and E. Noack Thiol-mediated generation of nitric oxide accounts for the vasodilator action of furoxans Biochem Pharmacol 44 1992 1149 1157
29. S.J. Kwon, K. Kim, I.H. Kim, I.K. Yoon, and J.W. Park Strand breaks in DNA induced by a thiol/Fe(III)/O2 mixed-function oxidase system and its protection by a yeast antioxidant protein Biochem Biophys Res Commun 192 1993 772 777
30. M.L. Blaxter, P. De Ley, and J.R. Garey A molecular evolutionary framework for the phylum Nematoda Nature 392 1998 71 75
31. J.L. Zawadzki, P.J. Presidente, E.N. Meeusen, and M.J. De Veer RNAi in Haemonchus contortus: a potential method for target validation Trends Parasitol 22 2006 495 499
32. K. Chaithirayanon, and P. Sobhon Molecular cloning and characterization of two genes encoding 2-Cys peroxiredoxins from Fasciola gigantica Exp Parasitol 125 2010 106 113
33. W.J. Piotrowski, T. Pietras, and Z. Kurmanowska Effect of paraquat intoxication and ambroxol treatment on hydrogen peroxide production and lipid peroxidation in selected organs of rat J Appl Toxicol 16 1996 501 507
34. M. Olahova, S.R. Taylor, and S. Khazaipoul A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance Proc Natl Acad Sci USA 105 2008 19839 19844
35. M. Mourao Mde, N. Dinguirard, G.R. Franco, and T.P. Yoshino Role of the endogenous antioxidant system in the protection of Schistosoma mansoni primary sporocysts against exogenous oxidative stress PLoS Negl Trop Dis 3 2009 e550
36. L. Flohe, J.R. Harris, and Introduction History of the peroxiredoxins and topical perspectives Subcell Biochem 44 2007 1 25
37. A. Carlioz, and D. Touati Isolation of superoxide dismutase mutants in Escherichia coli: is superoxide dismutase necessary for aerobic life? EMBO J 5 1986 623 630
38. H. Sztajer, B. Gamain, and K.D. Aumann The putative glutathione peroxidase gene of Plasmodium falciparum codes for a thioredoxin peroxidase J Biol Chem 276 2001 7397 7403
39. D. Parsonage, P.A. Karplus, and L.B. Poole Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin Proc Natl Acad Sci USA 105 2008 8209 8214
40. 2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis Apoptosis 11 2006 39 46
41. S.G. Rhee, H.Z. Chae, and K. Kim Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling Free Radic Biol Med 38 2005 1543 1552
42. S.G. Rhee, S.W. Kang, W. Jeong, T.S. Chang, K.S. Yang, and H.A. Woo Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins Curr Opin Cell Biol 17 2005 183 189
43. A.A. Sayed, A. Simeonov, C.J. Thomas, J. Inglese, C.P. Austin, and D.L. Williams Identification of oxadiazoles as new drug leads for the control of schistosomiasis Nat Med 14 2008 407 412
44. A. Holmgren Thioredoxin and glutaredoxin systems J Biol Chem 264 1989 13963 13966