Thrombosis in small and medium-sized pulmonary arteries in wegener's granulomatosis: A confocal laser scanning microscopy study;Trombose em artérias pulmonares pequenas e médias em granulomatose de wegener: Um estudo com microscopia confocal a laser

Jornal Brasileiro de Pneumologia

Volumn 36, Issue 6, 2010, Pages 724-730

  Santana, Alfredo Nicodemos Cruz ^a,b   Ab'Saber, Alexandre Muxfeldt ^a   Teodoro, Walcy Rosolio ^a   Capelozzi, Vera Luiza ^a   Barbas, Carmen Silvia Valente ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Hospital Regional da Asa Norte HRAN   (Brazil)

Author keywords

Antibodies; Antineutrophil cytoplasmic; Confocal; Lung; Microscopy; Thrombosis; Vasculitis; Wegener granulomatosis

Indexed keywords

EID: 78951483776     PISSN: 18063713     EISSN: 18063713     Source Type: Journal    
DOI: 10.1590/s1806-37132010000600009     Document Type: Article

References (30)

1. Santana AN, Souza R, Martins AP, Macedo F, Rascovski A, Salge JM. The effect of massive weight loss on pulmonary function of morbid obese patients. Respir Med. 2006;100(6):1100-4.
2. Baldi BG, Santana AN, Takagaki TY, Fujita C, Kairalla RA, Carvalho CR. Lung cyst: an unusual manifestation of Niemann-Pick disease. Respirology. 2009;14(1):134-6.
3. Santana AN, Antunes T, Barros JM, Kairalla RA, Carvalho CR, Barbas CS. Pulmonary involvement in Behcet's disease: a positive single-center experience with the use of immunosuppressive therapy. J Bras Pneumol. 2008;34(6):362-6.
4. Allenbach Y, Seror R, Pagnoux C, Teixeira L, Guilpain P, Guillevin L, et al. High frequency of venous thromboembolic events in Churg-Strauss syndrome, Wegener's granulomatosis and microscopic polyangiitis but not polyarteritis nodosa: a systematic retrospective study on 1130 patients. Ann Rheum Dis. 2009;68(4):564-7.
5. Leavitt RY, Fauci AS, Bloch DA, Michel BA, Hunder GG, Arend WP, et al. The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum. 1990;33(8):1101-7.
6. Stassen PM, Derks RP, Kallenberg CG, Stegeman CA. Venous thromboembolism in ANCA-associated vasculitis-incidence and risk factors. Rheumatology (Oxford). 2008;47(4):530-4.
7. Capelozzi VL, Parras ER, Ab'saber AM. Apresentação anatomopatológica das vasculites pulmonares. J Bras Pneumol. 2005;31(Suppl 1):S9-S15.
8. Merkel PA, Lo GH, Holbrook JT, Tibbs AK, Allen NB, Davis JC Jr, et al. Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study. Ann Intern Med. 2005;142(8):620-6.
9. Weidner S, Hafezi-Rachti S, Rupprecht HD. Thromboembolic events as a complication of antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 2006;55(1):146-9.
10. Mark EJ, Flieder DB, Matsubara O. Treated Wegener's granulomatosis: distinctive pathological findings in the lungs of 20 patients and what they tell us about the natural history of the disease. Hum Pathol. 1997;28(4):450-8.
11. Travis WD. Pathology of pulmonary vasculitis. Semin Respir Crit Care Med. 2004;25(5):475-82.
12. Travis WD, Hoffman GS, Leavitt RY, Pass HI, Fauci AS. Surgical pathology of the lung in Wegener's granulomatosis. Review of 87 open lung biopsies from 67 patients. Am J Surg Pathol. 1991;15(4):315-33.
13. Arnoni RT, Jatene FB, Bernardo WM, Aiello VD, Jatene T, Monteiro R, et al. Medial hypertrophy in patients with pulmonary embolism: anatomopathological study. Arq Bras Cardiol. 2007;88(6):660-6.
14. Tuder RM, Marecki JC, Richter A, Fijalkowska I, Flores S. Pathology of pulmonary hypertension. Clin Chest Med. 2007;28(1):23-42, vii.
15. Hughson MD, McCarty GA, Brumback RA. Spectrum of vascular pathology affecting patients with the antiphospholipid syndrome. Hum Pathol. 1995;26(7):716-24.
16. Pietra GG, Edwards WD, Kay JM, Rich S, Kernis J, Schloo B, et al. Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry. Circulation. 1989;80(5):1198-206.
17. Espinosa G, Cervera R, Font J, Asherson RA. The lung in the antiphospholipid syndrome. Ann Rheum Dis. 2002;61(3):195-8.
18. Johnson SR, Granton JT, Mehta S. Thrombotic arteriopathy and anticoagulation in pulmonary hypertension. Chest. 2006;130(2):545-52.
19. Whitaker AN, Emmerson BT, Bunce IH, Nicoll P, Sands JM. Reversal of renal failure in Wegener's granulomatosis cy heparin. Am J Med Sci. 1973;265(5):399-406.
20. Little MA, Smyth CL, Yadav R, Ambrose L, Cook HT, Nourshargh S, et al. Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo. Blood. 2005;106(6):2050-8.
21. Henshaw TJ, Malone CC, Gabay JE, Williams RC Jr. Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa. Arthritis Rheum. 1994;37(1):104-12.
22. Woywodt A, Streiber F, de Groot K, Regelsberger H, Haller H, Haubitz M. Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis. Lancet. 2003;361(9353):206-10.
23. Boehme MW, Schmitt WH, Youinou P, Stremmel WR, Gross WL. Clinical relevance of elevated serum thrombomodulin and soluble E-selectin in patients with Wegener's granulomatosis and other systemic vasculitides. Am J Med. 1996;101(4):387-94.
24. Antunes T, Carvalho CR, Ether EM, Capelozzi VL, Barbas CS. Expression of CD34 as a Marker of Endothelium in Apoptotic Cells in Wegeners Granulomatosis. Am J Respir Crit Care Med. 2003;167(Suppl 1):A118.
25. Santana AN, Antunes T, Barbas CS. Treatment of ANCA-associated vasculitis. JAMA. 2007;298(23):2739; author reply 2740.
26. Ridker PM, Goldhaber SZ, Danielson E, Rosenberg Y, Eby CS, Deitcher SR, et al. Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism. N Engl J Med. 2003;348(15):1425-34.
27. Kearon C, Ginsberg JS, Kovacs MJ, Anderson DR, Wells P, Julian JA, et al. Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism. N Engl J Med. 2003;349(7):631-9.
28. Esmon CT. Role of coagulation inhibitors in inflammation. Thromb Haemost. 2001;86(1):51-6.
29. Launay D, Souza R, Guillevin L, Hachulla E, Pouchot J, Simonneau G, et al. Pulmonary arterial hypertension in ANCA-associated vasculitis. Sarcoidosis Vasc Diffuse Lung Dis. 2006;23(3):223-8.
30. Coulomb-L'Hermine A, Capron F, Zou W, Piard F, Galateau F, Laurent P, et al. Expression of the chemokine RANTES in pulmonary Wegener's granulomatosis. Hum Pathol. 2001;32(3):320-6.