Effects of simvastatin therapy on circulating adipocytokines in patients with hypercholesterolemia

International Journal of Cardiology

Volumn 146, Issue 3, 2011, Pages 434-437

  Koh, Kwang Kon ^a   Quon, Michael J ^b   Sakuma, Ichiro ^c   Lee, Yonghee ^d   Lim, Soo ^e   Han, Seung Hwan ^a   Shin, Eak Kyun ^a  

^a Gachon University College of Medicine   (South Korea)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Hokko Memorial Clinic   (Japan)

^d University of Seoul   (South Korea)

^e Seoul National University Bundang Hospital   (South Korea)

Author keywords

Adipocytokines; Insulin resistance; Metabolic syndrome; Statins

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; C REACTIVE PROTEIN; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; RESISTIN; SIMVASTATIN; TRIACYLGLYCEROL;

DRUG EFFECT; ENZYME BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; HYPERCHOLESTEROLEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LETTER; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SIDE EFFECT; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 78951476544     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2010.10.103     Document Type: Article

References (19)

1. K.K. Koh Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability Cardiovasc Res 47 2000 648 657
2. T. Yada, M. Nakata, T. Shiraishi, and M. Kakei Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells Br J Pharmacol 126 1999 1205 1213
3. L.H. Chamberlain Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes FEBS Lett 507 2001 357 361
4. M. Kanda, K. Satoh, and K. Ichihara Effects of atorvastatin and pravastatin on glucose tolerance in diabetic rats mildly induced by streptozotocin Biol Pharm Bull 26 2003 1681 1684
5. S.H. Han, M.J. Quon, J.A. Kim, and K.K. Koh Adiponectin and cardiovascular disease: response to therapeutic interventions J Am Coll Cardiol 49 2007 531 538
6. B. Amasyali, A. Kilic, T. Celik, and A. Iyisoy A new frame in thromboembolic cardiovascular disease: adipocytokine Int J Cardiol 139 2010 100 102
7. K.K. Koh, S.M. Park, and M.J. Quon Leptin and cardiovascular disease: response to therapeutic interventions Circulation 117 2008 3238 3249
8. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143-421.
9. K.K. Koh, M.J. Quon, and S.H. Han Simvastatin improves flow-mediated dilation, but reduces adiponectin levels and insulin sensitivity in hypercholesterolemic patients Diab Care 31 2008 776 782
10. K.K. Koh, M.J. Quon, and S.H. Han Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients Atherosclerosis 204 2009 483 490
11. K.K. Koh, M.J. Quon, and S.H. Han Additive beneficial effects of losartan combined with simvastatin in the treatment of hypercholesterolemic, hypertensive patients Circulation 110 2004 3687 3692
12. K.K. Koh, M.J. Quon, S.H. Han, W.-J. Chung, Y. Lee, and E.K. Shin Anti-inflammatory and metabolic effects of candesartan in hypertensive patients Int J Cardiol 108 2006 96 100
13. K.K. Koh, S.H. Han, J.Y. Ahn, W.-J. Chung, Y. Lee, and E.K. Shin Amlodipine improves endothelial function and metabolic parameters in patients with hypertension Int J Cardiol 133 2009 23 31
14. A. Katz, S.S. Nambi, and K. Mather Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans J Clin Endocrinol Metab 85 2000 2402 2410
15. K.K. Koh, M.J. Quon, S.H. Han, Y. Lee, S.J. Kim, and E.K. Shin Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patients J Am Coll Cardiol 55 2010 1209 1216
16. S.H. Han, M.J. Quon, and K.K. Koh Reciprocal relationships between abnormal metabolic parameters and endothelial dysfunction Curr Opin Lipidol 18 2007 58 65
17. S. Li, H.J. Shin, E.L. Ding, and R.M. van Dam Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis JAMA 302 2009 179 188
18. L.G. Shewan, and A.J. Coats Ethics in the authorship and publishing of scientific articles Int J Cardiol 144 2010 1 2
19. A.J. Coats Ethical authorship and publishing Int J Cardiol 131 2009 149 150