The incidence and outcomes of fetomaternal alloimmune thrombocytopenia: A UK national study using three data sources

British Journal of Haematology

Volumn 152, Issue 4, 2011, Pages 460-468

  Knight, Marian ^a   Pierce, Matthias ^a   Allen, Dave ^a,b   Kurinczuk, Jennifer J ^a   Spark, Patsy ^a   Roberts, David J ^a,b   Murphy, Michael F ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

Author keywords

Cohort; Epidemiology; Fetomaternal alloimmune thrombocytopenia; Incidence

Indexed keywords

CORTICOSTEROID; IMMUNOGLOBULIN;

ARTICLE; BLEEDING; BRAIN HEMORRHAGE; CONTROLLED STUDY; DESCRIPTIVE RESEARCH; FETUS; HUMAN; INCIDENCE; INFANT; INTRAUTERINE BLOOD TRANSFUSION; MAJOR CLINICAL STUDY; NEONATAL ALLOIMMUNE THROMBOCYTOPENIA; POPULATION RESEARCH; PRENATAL SCREENING; PRIORITY JOURNAL; UNITED KINGDOM;

FEMALE; GESTATIONAL AGE; GREAT BRITAIN; HEMORRHAGE; HUMANS; INCIDENCE; INFANT, NEWBORN; PLATELET COUNT; POPULATION SURVEILLANCE; PREGNANCY; PREGNANCY OUTCOME; PRENATAL DIAGNOSIS; PROGNOSIS; THROMBOCYTOPENIA, NEONATAL ALLOIMMUNE;

EID: 78851469708     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08540.x     Document Type: Article

References (29)

1. Bessos, H., Killie, M.K., Seghatchian, J., Skogen, B. & Urbaniak, S.J. (2009) The relationship of anti-HPA-1a amount to severity of neonatal alloimmune thrombocytopenia - Where does it stand? Transfusion and Apheresis Science, 40, 75-78.
2. British Paediatric Surveillance Unit (2004) British Paediatric Surveillance Unit. Available at:. Accessed 20 July 2010.
3. Bussel, J. (2009) Diagnosis and management of the fetus and neonate with alloimmune thrombocytopenia. Journal of Thrombosis and Haemostasis, 7(Suppl. 1), 253-257.
4. Davoren, A., McParland, P., Barnes, C.A. & Murphy, W.G. (2002) Neonatal alloimmune thrombocytopenia in the Irish population: a discrepancy between observed and expected cases. Journal of Clinical Pathology, 55, 289-292.
5. Dreyfus, M., Kaplan, C., Verdy, E., Schlegel, N., Durand-Zaleski, I. & Tchernia, G. (1997) Frequency of immune thrombocytopenia in newborns: a prospective study. Immune Thrombocytopenia Working Group. Blood, 89, 4402-4406.
6. General Register Office for Scotland (2007) Scotland's Population 2006: The Registrar General's Annual Review of Demographic Trends. General Register Office for Scotland, Edinburgh.
7. General Registers Office (2008) Scotland's Population 2007: The Registrar General's Annual Review of Demographic Trends. General Register Office for Scotland, Edinburgh.
8. General Registers Office (2009) Scotland's Population 2008: The Registrar General's Annual Review of Demographic Trends. General Register Office for Scotland, Edinburgh.
9. Hook, E.B. & Regal, R.R. (1995) Capture-recapture methods in epidemiology: methods and limitations. Epidemiologic Reviews, 17, 243-264.
10. INOSS (2010) The International Network of Obstetric Survey Systems. Available at: Accessed 23 June 2010.
11. Kamphuis, M.M., Paridaans, N., Porcelijn, L., De Haas, M., van der Schoot, C.E., Brand, A., Bonsel, G.J. & Oepkes, D. (2010) Screening in pregnancy for fetal or neonatal alloimmune thrombocytopenia: systematic review. British Journal of Obstetrics and Gynaecology, 117(11): 1335-43.
12. Kjeldsen-Kragh, J., Killie, M.K., Tomter, G., Golebiowska, E., Randen, I., Hauge, R., Aune, B., Oian, P., Dahl, L.B., Pirhonen, J., Lindeman, R., Husby, H., Haugen, G., Gronn, M., Skogen, B. & Husebekk, A. (2007) A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia. Blood, 110, 833-839.
13. Knight, M., Kurinczuk, J.J., Tuffnell, D. & Brocklehurst, P. (2005) The UK Obstetric Surveillance System for rare disorders of pregnancy. British Journal of Obstetrics and Gynaecology, 112, 263-265.
14. Murphy, M.F. & Bussel, J.B. (2007) Advances in the management of alloimmune thrombocytopenia. British Journal of Haematology, 136, 366-378.
15. Murphy, M.F., Williamson, L.M. & Urbaniak, S.J. (2002) Antenatal screening for fetomaternal alloimmune thrombocytopenia: should we be doing it? Vox Sanguinis, 83(Suppl. 1), 409-416.
16. Northern Ireland Statistics and Research Agency (2009) Registrar General Annual Report 2008. Northern Ireland Statistics and Research Agency, Belfast.
17. Office for National Statistics (2008) Birth Statistics 2006 Series FM1 No.35. Office for National Statistics, Newport.
18. Office for National Statistics (2009) Birth Statistics 2007 Series FM1 No.36. Office for National Statistics, Newport.
19. Office for National Statistics (2010) Birth Statistics 2008 Series FM1 No.37. Office for National Statistics, Newport.
20. Radder, C.M., de Haan, M.J., Brand, A., Stoelhorst, G.M., Veen, S. & Kanhai, H.H. (2004) Follow up of children after antenatal treatment for alloimmune thrombocytopenia. Early Human Development, 80, 65-76.
21. Rayment, R., Kooij, T.W., Zhang, W., Siebold, C., Murphy, M.F., Allen, D., Willcox, N. & Roberts, D.J. (2009) Evidence for the specificity for platelet HPA-1a alloepitope and the presenting HLA-DR52a of diverse antigen-specific helper T cell clones from alloimmunized mothers. Journal of Immunology, 183, 677-686.
22. Regal, R.R. & Hook, E.B. (1984) Goodness-of-fit based confidence intervals for estimates of the size of a closed population. Statistics in Medicine, 3, 287-291.
23. Serrarens-Janssen, V.M., Steegers, E.A., van den Bos, A., van Heijst, A.F., Pereira, R. & Semmekrot, B.A. (2005) Experiences with fetomaternal alloimmune thrombocytopenia in the Netherlands over a 2-year period. Acta Obstetrica et Gynecologica Scandinavica, 84, 203.
24. Tiller, H., Killie, M.K., Skogen, B., Oian, P. & Husebekk, A. (2009) Neonatal alloimmune thrombocytopenia in Norway: poor detection rate with nonscreening versus a general screening programme. British Journal of Obstetrics and Gynaecology, 116, 594-598.
25. Tilling, K., Sterne, J.A. & Wolfe, C.D. (2001) Estimation of the incidence of stroke using a capture-recapture model including covariates. International Journal of Epidemiology, 30, 1351-1359; discussion 1359-1360.
26. Turner, M.L., Bessos, H., Fagge, T., Harkness, M., Rentoul, F., Seymour, J., Wilson, D., Gray, I., Ahya, R., Cairns, J. & Urbaniak, S. (2005) Prospective epidemiologic study of the outcome and cost-effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia due to anti-HPA-1a. Transfusion, 45, 1945-1956.
27. UK National Screening Committee (2010) Criteria for Appraising the Viability, Effectiveness and Appropriateness of a Screening Programme. Available at: Accessed 19 October 2010.
28. Ward, M.J., Pauliny, J., Lipper, E.G. & Bussel, J.B. (2006) Long-term effects of fetal and neonatal alloimmune thrombocytopenia and its antenatal treatment on the medical and developmental outcomes of affected children. American Journal of Perinatology, 23, 487-492.
29. Williamson, L.M., Hackett, G., Rennie, J., Palmer, C.R., Maciver, C., Hadfield, R., Hughes, D., Jobson, S. & Ouwehand, W.H. (1998) The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening. Blood, 92, 2280-2287.