Molecular structure, mechanical behavior and failure mechanism of the C-terminal cross-link domain in type I collagen

Journal of the Mechanical Behavior of Biomedical Materials

Volumn 4, Issue 2, 2011, Pages 153-161

  Uzel, Sebastien G M ^a   Buehler, Markus J ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Connective tissue; Cross link; Fibril; Materiomics; Mechanical properties; Molecular model; Nanomechanics; Type I collagen

Indexed keywords

CONNECTIVE TISSUES; CROSS-LINK; FIBRIL; MATERIOMICS; MOLECULAR MODELS; TYPE I COLLAGEN;

BIOMECHANICS; BLOOD VESSELS; COMPUTER SIMULATION; DEFORMATION; MECHANICAL PROPERTIES; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR MODELING; MUSCULOSKELETAL SYSTEM; NANOMECHANICS; STRAIN; TISSUE;

COLLAGEN;

COLLAGEN TYPE 1;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL STRUCTURE; CONNECTIVE TISSUE; CROSS LINKING; GEOMETRY; LARGE SCALE MOLECULAR DYNAMICS SIMULATION; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BIOMECHANICS; COLLAGEN TYPE I; COMPUTATIONAL BIOLOGY; MECHANICAL PROCESSES; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; STRESS, MECHANICAL;

EID: 78751703561     PISSN: 17516161     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmbbm.2010.07.003     Document Type: Article

References (32)

1. Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P. Molecular Biology of the Cell 2002, Taylor & Francis, New York.
2. Bailey A.J. Molecular mechanisms of ageing in connective tissues. Mechanisms of Ageing and Development 2001, 122(7):735-755.
3. Bozec L., Horton M. Topography and mechanical properties of single molecules of type I collagen using atomic force microscopy. Biophysical Journal 2005, 88(6):4223-4231.
4. Buehler M.J. Nature designs tough collagen: explaining the nanostructure of collagen fibrils. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(33):12285-12290.
5. Buehler M.J. Nanomechanics of collagen fibrils under varying cross-link densities: atomistic and continuum studies. Journal of the Mechanical Behavior of Biomedical Materials 2008, 1(1):59-67.
6. Buehler M.J., Yung Y.C. Deformation and failure of protein materials in physiologically extreme conditions and disease. Nature Materials 2009, 8(3):175-188.
7. Das R., Baker D. Macromolecular modeling with Rosetta. Annual Review of Biochemistry 2008, 77:363-382.
8. Eyre D.R., Weis M.A., Wu J.J. Advances in collagen cross-link analysis. Methods 2008, 45(1):65-74.
9. Farre A., Horst A.V.D., Blab G.A., Downing B.P.B., Forde N.R. Stretching single DNA molecules to demonstrate high-force capabilities of holographic optical tweezers. Journal of Biophotonics 2010, 10.1002/jbio.200900107.
10. Fratzl P., Weinkamer R. Nature's hierarchical materials. Progress in Materials Science 2007, 52:1263-1334.
11. Gautieri A., Buehler M.J., Redaelli A. Deformation rate controls elasticity and unfolding pathway of single tropocollagen molecules. Journal of the Mechanical Behavior of Biomedical Materials 2009, 2(2):130-137.
12. Gautieri A., Uzel S., Vesentini S., Redaelli A., Buehler M.J. Molecular and mesoscale mechanisms of osteogenesis imperfecta disease in collagen fibrils. Biophysical Journal 2009, 97(3):857-865.
13. Gelse K., Poschl E., Aigner T. Collagens-structure, function, and biosynthesis. Advanced Drug Delivery Reviews 2003, 55(12):1531-1546.
14. Gupta H.S., Seto J., Krauss S., Boesecke P., Screen H.R.C. In situ multi-level analysis of viscoelastic deformation mechanisms in tendon collagen. Journal of Structural Biology 2010, 169(2):183-191.
15. Harley B.A., Leung J.H., Silva E.C., Gibson L.J. Mechanical characterization of collagen-glycosaminoglycan scaffolds. Acta Biomaterialia 2007, 3(4):463-474.
16. Humphrey W., Dalke A., Schulten K. VMD: visual molecular dynamics. Journal of Molecular Graphics 1996, 14(1):33.
17. Karplus M., McCammon J.A. Molecular dynamics simulations of biomolecules. Nature Structural Biology 2002, 9(9):646-652.
18. Knott L., Bailey A.J. Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance. Bone 1998, 22(3):181-187.
19. Light N.D., Bailey A.J. Chemistry of the collagen cross-links-purification and characterization of cross-linked polymeric peptide material from mature collagen containing unknown amino-acids. Biochemical Journal 1980, 185(2):373-381.
20. Lu H., Isralewitz B., Krammer A., Vogel V., Schulten K. Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation. Biophysical Journal 1998, 75(2):662-671.
21. MacKerell A.D., Bashford D., Bellott M., Dunbrack R.L., Evanseck J.D., Field M.J., Fischer S., Gao J., Guo H., Ha S., Joseph-McCarthy D., Kuchnir L., Kuczera K., Lau F.T.K., Mattos C., Michnick S., Ngo T., Nguyen D.T., Prodhom B., Reiher W.E., Roux B., Schlenkrich M., Smith J.C., Stote R., Straub J., Watanabe M., Wiorkiewicz-Kuczera J., Yin D., Karplus M. All-atom empirical potential for molecular modeling and dynamics studies of proteins. Journal of Physical Chemistry B 1998, 102(18):3586-3616.
22. Orgel J., Irving T.C., Miller A., Wess T.J. Microfibrillar structure of type I collagen in situ. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(24):9001-9005.
23. Orgel J., Miller A., Irving T.C., Fischetti R.F., Hammersley A.P., Wess T.J. The in situ supermolecular structure of type I collagen. Structure 2001, 9(11):1061-1069.
24. Ortiz C., Boyce M.C. Materials science-bioinspired structural materials. Science 2008, 319(5866):1053-1054.
25. Piez K.A., Trus B.L. A New model for packing of type-I collagen molecules in the native fibril. Bioscience Reports 1981, 1(10):801-810.
26. Prockop D.J., Kivirikko K.I. Collagens-molecular-biology, diseases, and potentials for therapy. Annual Review of Biochemistry 1995, 64:403-434.
27. Rainey J.K., Goh M.C. An interactive triple-helical collagen builder. Bioinformatics 2004, 20(15):2458-2459.
28. Rauch F., Glorieux F.H. Osteogenesis imperfecta. Lancet 2004, 363(9418):1377-1385.
29. Reiser K., McCormick R.J., Rucker R.B. Enzymatic and nonenzymatic cross-linking of collagen and elastin. The FASEB Journal 1992, 6(7):2439-2449.
30. Saito M., Marumo K. Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporosis International 2009, 21(2):195-214.
31. Sillence D.O., Senn A., Danks D.M. Genetic-heterogeneity in osteogenesis imperfecta. Journal of Medical Genetics 1979, 16(2):101-116.
32. Sun Y.L., Luo Z.P., Fertala A., An K.N. Stretching type II collagen with optical tweezers. Journal of Biomechanics 2004, 37(11):1665-1669.