Vancomycin bonded to bone grafts prevents bacterial colonization

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 2, 2011, Pages 487-494

  Ketonis, Constantinos ^a   Barr, Stephanie ^a   Adams, Christopher S ^a,c   Shapiro, Irving M ^a   Parvizi, Javad ^a,b   Hickok, Noreen J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b ROTHMAN INSTITUTE   (United States)

^c PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; VANCOMYCIN;

AIR; ANTIBIOTIC THERAPY; AQUEOUS SOLUTION; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ADHERENCE; BIOFILM; BONE ALLOGRAFT; CELL VIABILITY; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG BINDING; ESCHERICHIA COLI; GRAFT INFECTION; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; INOCULATION; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; SURFACE PROPERTY; TOPOGRAPHY;

ANTI-BACTERIAL AGENTS; BACTERIAL ADHESION; BIOFILMS; BONE AND BONES; BONE TRANSPLANTATION; CELL ADHESION; CELL LINE; COLONY COUNT, MICROBIAL; HUMANS; MICROSCOPY, CONFOCAL; OSTEOBLASTS; STAPHYLOCOCCUS AUREUS; VANCOMYCIN;

EID: 78751694015     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00741-10     Document Type: Article

References (17)

1. Antoci, V., Jr., C. S. Adams, N. J. Hickok, I. M. Shapiro, and J. Parvizi. 2007. Antibiotics for local delivery systems cause skeletal cell toxicity in vitro. Clin. Orthop. Rel. Res. 462:200-206.
2. Boyce, T., J. Edwards, and N. Scarborough. 1999. Allograft bone. The influence of processing on safety and performance. Orthop. Clin. North Am. 30:571-581.
3. Bullens, P., et al. 2009. Survival of massive allografts in segmental oncological bone defect reconstructions. Int. Orthop. 33:757-760.
4. Buttaro, M., F. Comba, and F. Piccaluga. 2007. Vancomycin-supplemented cancellous bone allografts in hip revision surgery. Clin. Orthop. Rel. Res. 461:74-80.
5. Costerton, J. W. 2005. Biofilm theory can guide the treatment of devicerelated orthopaedic infections. Clin. Orthop. Rel. Res. 437:7-11.
6. Costerton, J. W., P. S. Stewart, and E. P. Greenberg. 1999. Bacterial biofilms: a common cause of persistent infections. Science 284:1318-1322.
7. Edin, M., T. Miclau, G. Lester, R. Lindsey, and L. Dahners. 1996. Effect of cefazolin and vancomycin on osteoblasts in vitro. Clin. Orthop. Rel. Res. 454:245-251.
8. Harris, S. A., R. J. Enger, B. L. Riggs, and T. C. Spelsberg. 1995. Development and characterization of a conditionally immortalized human fetal osteoblastic cell line. J. Bone Min. Res. 10:178-186.
9. Ketonis, C., et al. 2010. Antibiotic modification of native grafts: improving upon nature's scaffolds. Tiss. Eng. A 16:2041-2049.
10. Ketonis, C., et al. 28 October 2010. Antibacterial activity of bone allografts: comparison of a new vancomycin-tethered allograft with allograft loaded with adsorbed vancomycin. Bone [Epub ahead of print.] doi:10.1016/j.bone.2010.10.171.
11. Lord, C., M. Gebhardt, W. Tomford, and H. Mankin. 1988. Infection in bone allografts. Incidence, nature, and treatment. J. Bone Joint Surg. Am. 70:369-376.
12. Lundstrom, T., and J. Sobel. 2004. Antibiotics for gram-positive bacterial infections: vancomycin, quinupristin-dalfopristin, linezolid, and daptomycin. Infect. Dis. Clin. North Am. 18:651-668.
13. Shah, A. K., R. K. Sinha, N. J. Hickok, and R. S. Tuan. 1999. High-resolution morphometric analysis of human osteoblastic cell adhesion on clinically relevant orthopedic alloys. Bone 24:499-506.
14. Sigma-Aldrich. 2010. TOX7 technical bulletin. Sigma-Aldrich, St. Louis, MO.
15. Thermo Scientific. 2010. Overview of protein assay methods. Thermo Scientific, Rockford, IL.
16. Trampuz, A., et al. 2007. Sonication of removed hip and knee prostheses for diagnosis of infection. N. Engl. J. Med. 16:654-663.
17. Witso, E., L. Persen, P. Benum, and K. Bergh. 2005. Cortical allograft as a vehicle for antibiotic delivery. Acta Orthop. 76:481-486. (Pubitemid 41232777)