The public health utility of genome-wide association study results for smoking behavior

Genome Medicine

Volumn 2, Issue 4, 2010, Pages

  Furberg, Helena ^a,b   Ostroff, Jamie ^a   Lerman, Caryn ^c   Sullivan, Patrick F ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; VARENICLINE;

BEHAVIORAL SCIENCE; CLINICAL PRACTICE; ECONOMICS; ENVIRONMENTAL IMPACT; ETHICS; GENE INTERACTION; GENETIC ASSOCIATION; HEALTH CARE UTILIZATION; HUMAN; NICOTINE REPLACEMENT THERAPY; NOTE; PHARMACOGENETICS; PRIORITY JOURNAL; SMOKING; SMOKING CESSATION; TRANSLATIONAL RESEARCH;

EID: 78751690293     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/gm147     Document Type: Note

References (20)

1. Rose RJ, Broms U, Korhonen T, Dick DM, Kaprio J. Genetics of Smoking Behavior. Handbook of Behavior Genetics, 1 2009, 411-432. New York: Springer, Kim Y-K, 1.
2. Furberg H, Kim Y, Dackor J, Boerwinkle E, Franceschini N, Ardissino D, Bernardinelli L, Mannucci PM, Mauri F, Merlini PA, Absher D, Assimes TL, Fortmann SP, Iribarren C, Knowles JW, Quertermous T, Ferrucci L, Tanaka T, Bis JC, Furberg CD, Haritunians T, McKnight B, Psaty BM, Taylor KD, Thacker EL, Almgren P, Groop L, Ladenvall C, Boehnke M, Jackson AU, et al. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 2010, doi:10.1038/ng.571..
3. Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F, Sulem P, Rafnar T, Esko T, Walter S, Gieger C, Rawal R, Mangino M, Prokopenko I, Mägi R, Keskitalo K, Gudjonsdottir IH, Gretarsdottir S, Stefansson H, Thompson JR, Aulchenko YS, Nelis M, Aben KK, den Heijer M, Dirksen A, Ashraf H, Soranzo N, Valdes AM, Steves C, Uitterlinden AG, et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 2010, doi:10.1038/ng.573..
4. Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, de Berrettini W, Knouff CW, Yuan X, Waeber G, Vollenweider P, Preisig M, Wareham NJ, Zhao JH, Loos RJF, Barroso I, Khaw K-T, Grundy S, Barter P, Mahley R, Kesaniemi A, McPherson R, Vincent JB, Strauss J, Kennedy JL, Farmer A, McGuffin P, Day R, Matthews K, Bakke P, et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 2010, doi:10.1038/ng.572..
5. Bierut LJ, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF, Swan GE, Rutter J, Bertelsen S, Fox L, Fugman D, Goate AM, Hinrichs AL, Konvicka K, Martin NG, Montgomery GW, Saccone NL, Saccone SF, Wang JC, Chase GA, Rice JP, Ballinger DG. Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet 2007, 16:24-35. 10.1093/hmg/ddl441, 2278047, 17158188.
6. Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J, Sullivan K, Matakidou A, Wang Y, Mills G, Doheny K, Tsai YY, Chen WV, Shete S, Spitz MR, Houlston RS. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet 2008, 40:616-622. 10.1038/ng.109, 2713680, 18385676.
7. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Chen C, Goodman G, Field JK, Liloglou T, Xinarianos G, Cassidy A, McLaughlin J, Liu G, Narod S, Krokan HE, Skorpen F, Elvestad MB, Hveem K, Vatten L, Linseisen J, et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 2008, 452:633-637. 10.1038/nature06885, 18385738.
8. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature 2009, 461:747-753. 10.1038/nature08494, 2831613, 19812666.
9. Kraft P, Hunter DJ. Genetic risk prediction - are we there yet?. N Engl J Med 2009, 360:1701-1703. 10.1056/NEJMp0810107, 19369656.
10. Ware JH. The limitations of risk factors as prognostic tools. N Engl J Med 2006, 355:2615-2617. 10.1056/NEJMp068249, 17182986.
11. Drgon T, Montoya I, Johnson C, Liu QR, Walther D, Hamer D, Uhl GR. Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers. Mol Med 2009, 15:21-27. 10.2119/molmed.2009.00040, 2581605,2581605, 19009022.
12. Guessous I, Gwinn M, Khoury MJ. Genome-wide association studies in pharmacogenomics: untapped potential for translation. Genome Med 2009, 1:46. 10.1186/gm46, 2684667, 19439031.
13. Lerman CE, Schnoll RA, Munafo MR. Genetics and smoking cessation improving outcomes in smokers at risk. Am J Prev Med 2007, 33:S398-S405. 10.1016/j.amepre.2007.09.006, 2170888, 18021915.
14. Crowley JJ, Sullivan PF, McLeod HL. Pharmacogenomic genome-wide association studies: lessons learned thus far. Pharmacogenomics 2009, 10:161-163. 10.2217/14622416.10.2.161, 19207016.
15. Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. Arch Gen Psychiatry 2008, 65:683-693. 10.1001/archpsyc.65.6.683, 2430596, 18519826.
16. Kuehn BM. Varenicline gets stronger warnings about psychiatric problems, vehicle crashes. JAMA 2009, 302:834. 10.1001/jama.2009.1153, 19706852.
17. Levy DT, Romano E, Mumford E. The relationship of smoking cessation to sociodemographic characteristics, smoking intensity, and tobacco control policies. Nicotine Tob Res 2005, 7:387-396. 10.1080/14622200500125443, 16085506.
18. McBride CM, Brody LC. Point: genetic risk feedback for common disease time to test the waters. Cancer Epidemiol Biomarkers Prev 2007, 16:1724-1726. 10.1158/1055-9965.EPI-07-0102, 17855688.
19. Shields AE, Fortun M, Hammonds EM, King PA, Lerman C, Rapp R, Sullivan PF. The use of race variables in genetic studies of complex traits and the goal of reducing health disparities: a transdisciplinary perspective. Am Psychol 2005, 60:77-103. 10.1037/0003-066X.60.1.77, 15641924.
20. Shields A, Lerman C, Sullivan P. Translating emerging research on the genetics of smoking into clinical practice: ethical and social considerations. Nicotine Tob Res 2004, 6:675-688. 10.1080/14622200410001734058, 15370164.