Preservation of TSPO by chronic intermittent hypobaric hypoxia confers antiarrhythmic activity

Journal of Cellular and Molecular Medicine

Volumn 15, Issue 1, 2011, Pages 134-140

  Li, Jun ^a,b   Xu, Jiahong ^b   Xiao, Junjie ^a,b   Zhang, Hong ^a,b   Liang, Dandan ^a,b   Liu, Yi ^a,b,c   Zhang, Yangyang ^d   Liu, Ying ^b   Wen, Wei ^b   Hu, Yaer ^e   Yu, Zhuo ^f   Yan, Biao ^c   Jiang, Bing ^b   Zhou, Zhao Nian ^f   Chen, Yi Han ^a,b,c  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c TONGJI UNIVERSITY   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

^e SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^f Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

Hypoxia; Mitochondria; Ventricular fibrillation

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANTIARRHYTHMIC AGENT; BZRP PROTEIN, RAT; CALCIUM; CARRIER PROTEIN; MESSENGER RNA;

ANIMAL; ANOXIA; ARTICLE; CHRONIC DISEASE; DISEASE MODEL; GENETICS; HEART ARRHYTHMIA; ISCHEMIA; MALE; METABOLISM; MITOCHONDRION; PATHOLOGY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; ANOXIA; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; BLOTTING, WESTERN; CALCIUM; CARRIER PROTEINS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; ISCHEMIA; MALE; MITOCHONDRIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

RATTUS;

EID: 78751682409     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00949.x     Document Type: Article

References (22)

1. Rubart M, Zipes DP. Mechanisms of sudden cardiac death. J Clin Invest. 2005; 115: 2305-15.
2. Maloney JP, Broeckel U. Epidemiology, risk factors, and genetics of high-altitude-related pulmonary disease. Clin Chest Med. 2005; 26: 395-404.
3. Asemu G, Papousek F, Ostádal B, et al Adaptation to high altitude hypoxia protects the rat heart against ischemia-induced arrhythmias. Involvement of mitochondrial K(ATP) channel. J Mol Cell Cardiol. 1999; 31: 1821-31.
4. Meerson FZ, Ustinova EE, Manukhina EB. Prevention of cardiac arrhythmias by adaptation to hypoxia: regulatory mechanisms and cardiotropic effect. Biomed Biochim Acta. 1989; 48: S83-8.
5. O'Rourke B, Cortassa S, Aon MA. Mitochondrial ion channels: gatekeepers of life and death. Physiology. 2005; 20: 303-15.
6. Gavish M, Bachman I, Shoukrun R, et al Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev. 1999; 51: 629-50.
7. Mukhin AG, Papadopoulos V, Costa E, et al Mitochondrial benzodiazepine receptors regulate steroid biosynthesis. Proc Natl Acad Sci USA. 1989; 86: 9813-6.
8. Leducq N, Bono F, Sulpice T, et al Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion. J Pharmacol Exp Ther. 2003; 306: 828-37.
9. Akar FG, Aon MA, Tomaselli GF, et al The mitochondrial origin of postischemic arrhythmias. J Clin Invest. 2005; 115: 3527-35.
10. Li J, Xiao J, Liu Y, et al Mitochondrial benzodiazepine receptors mediate cardioprotection of estrogen against ischemic ventricular fibrillation. Pharmacol Res. 2009; 60: 61-7.
11. Curtis MJ. Characterisation, utilisation and clinical relevance of isolated perfused heart models of ischaemia-induced ventricular fibrillation. Cardiovasc Res. 1998; 39: 194-215.
12. McEnery MW, Snowman AM, Trifiletti RR, et al Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA. 1992; 89: 3170-4.
13. Garber PM, Mezl VA. Cardiac mRNA levels during the development and growth of the rat. Basic Res Cardiol. 1988; 83: 384-91.
14. Parola AL, Stump DG, Pepperl DJ, et al Cloning and expression of a pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein. J Biol Chem. 1991; 266: 14082-7.
15. Inesi G, De Meis L. Regulation of steady state filling in sarcoplasmic reticulum. Roles of back-inhibition, leakage, and slippage of the calcium pump.. J Biol Chem. 1989; 264: 5929-36.
16. 21 overload injury. Life Sci. 2004; 76: 559-72.
17. Xie Y, Zhu Y, Zhu WZ, et al Role of dual-site phospholamban phosphorylation in intermittent hypoxia-induced cardioprotection against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2005; 288: H2594-602.
18. Zhu WZ, Xie Y, Chen L, et al Intermittent high altitude hypoxia inhibits opening of mitochondrial permeability transition pores against reperfusion injury. J Mol Cell Cardiol. 2006; 40: 96-106.
19. Del Monte F, Lebeche D, Guerrero JL, et al Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. Proc Natl Acad Sci USA. 2004; 101: 5622-7.
20. Ter Keurs HE, Boyden PA. Calcium and arrhythmogenesis. Physiol Rev. 2007; 87: 457-506.
21. Temsah RM, Kawabata K, Chapman D, et al Modulation of cardiac sarcoplasmic reticulum gene expression by lack of oxygen and glucose. FASEB J. 2001; 15: 2515-7.
22. Garcia-Dorado D, Piper HM, Eisner DA. Sarcoplasmic reticulum and mitochondria in cardiac pathophysiology. Cardiovasc Res. 2008; 77: 231-3.