Effects of mechanical stimulation in osteogenic differentiation of bone marrow-derived mesenchymal stem cells on aligned nanofibrous scaffolds

Journal of Bioactive and Compatible Polymers

Volumn 26, Issue 1, 2011, Pages 56-70

  Ngiam, Michelle ^a   Liao, Susan ^b   Ong Jun Jie, Timothy ^a   Xiaodi Sui, ^a   Yixiang Dong, ^c   Ramakrishna, S ^a,d,e   Chan, Casey K ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

^e INSTITUTE OF MATERIALS RESEARCH AND ENGINEERING   (Singapore)

Author keywords

cell adhesion; cyclic stretching; mesenchymal stem cells; nanofibers; osteogenic differentiation

Indexed keywords

ALKALINE PHOSPHATASE; BIOLOGICAL RESPONSE; BONE MARROW-DERIVED MESENCHYMAL STEM CELLS; BONE REGENERATION; CAST FILM; CELL SUBSTRATES; CELLULAR RESPONSE; CYCLIC STRETCHING; MECHANICAL STIMULATION; MECHANICAL STIMULUS; MESENCHYMAL STEM CELL; NANOFIBROUS SCAFFOLDS; OSTEOBLASTIC ACTIVITY; OSTEOCALCIN; OSTEOGENIC DIFFERENTIATION; SURFACE TEXTURES; UNIAXIAL CYCLIC STRAIN;

ADHESION; BONE; CELL ADHESION; FLOWCHARTING; NANOFIBERS; PHOSPHATASES; STEM CELLS; SUBSTRATES;

CELL CULTURE;

ALKALINE PHOSPHATASE; MOLECULAR SCAFFOLD; NANOFIBER; OSTEOCALCIN;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE MARROW; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; FILM; HUMAN; HUMAN CELL; MALE; MECHANICAL STIMULATION; MESENCHYMAL STEM CELL; NONHUMAN; SURFACE PROPERTY;

EID: 78751675699     PISSN: 08839115     EISSN: 15308030     Source Type: Journal    
DOI: 10.1177/0883911510393162     Document Type: Article

References (38)

1. Bloomfield SA Changes in musculoskeletal structure and function with prolonged bed rest. Med Sci Sports Exerc 1997 ; 29: 197-206.
2. Takamoto S., Masuyama T., Nakajima M., Seikiya K., Kosaka H., Morimoto S., et al. Alterations of bone mineral density of the femurs in hemiplegia. Calcif Tissue Int 1995 ; 56: 259-262.
3. McCarthy I., Goodship A., Herzog R., Oganov V., Stussi E. and Vahlensieck M. Investigation of bone changes in microgravity during long and short duration space flight: comparison of techniques. Eur J Clin Invest 2000 ; 30: 1044-1054.
4. Marchetti ME, Houde JP, Steinberg GG, Crane GK, Goss TP and Baran DT Humeral bone density losses after shoulder surgery and immobilization. J Shoulder Elbow Surg 1996 ; 5: 471-476.
5. Chesnut CH Bone mass and exercise. Am J Med 1993 ; 95: S34 - S36.
6. Shimamura C., Iwamoto J., Takeda T., Ichimura S., Abe H. and Toyama Y. Effect of decreased physical activity on bone mass in exercise-trained young rats. J Orthop Sci 2002 ; 7: 358-363.
7. Angele P., Yoo JU, Smith C., Mansour J., Jepsen KJ, Nerlich M., et al. Cyclic hydrostatic pressure enhances the chondrogenic phenotype of human mesenchymal progenitor cells differentiated in vitro. J Orthop Res 2003 ; 21: 451-457.
8. Huang CYC, Hagar KL, Frost LE, Sun YB and Cheung HS Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells. Stem Cells 2004 ; 22: 313-323.
9. Koike M., Shimokawa H., Kanno Z., Ohya K. and Soma K. Effects of mechanical strain on proliferation and differentiation of bone marrow stromal cell line ST2. J Bone Miner Metab 2005 ; 23: 219-225.
10. Sumanasinghe RD, Bernacki SH and Loboa EG Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression. Tissue Eng 2006 ; 12: 3459-3465.
11. Kaspar D., Seidl W., Neidlinger-Wilke C., Beck A., Claes L. and Ignatius A. Proliferation of human-derived osteoblast-like cells depends on the cycle number and frequency of uniaxial strain. J Biomech 2002 ; 35: 873-880.
12. Lanyon LE and Rubin CT Static vs dynamic loads as an influence on bone remodeling. J Biomech 1984 ; 17: 897-905.
13. McMahon LA, Reid AJ, Campbell VA and Prendergast PJ Regulatory effects of mechanical strain on the chondrogenic differentiation of MSCs in a collagen-GAG scaffold: experimental and computational analysis. Ann Biomed Eng 2008 ; 36: 185-194.
14. David V., Guignandon A., Martin A., Malaval L., Lafage-Proust MH, Rattner A., et al. Ex vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain. Tissue Eng A 2008 ; 14: 117-126.
15. Woo KM, Chen VJ and Ma PX Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment. J Biomed Mater Res A 2003 ; 67: 531-537.
16. Ghasemi-Mobarakeh L., Prabhakaran MP, Morshed M., Nasr-Esfahani MH and Ramakrishna S. Electrospun poly(-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering. Biomaterials 2008 ; 29: 4532-4539.
17. Yin Z., Chen X., Chen JL, Shen WL, Hieu Nguyen TM, Gao L., et al. The regulation of tendon stem cell differentiation by the alignment of nanofibers. Biomaterials 2009 ; 31: 2163-2175.
18. Hashi CK, Zhu Y., Yang GY, Young WL, Hsiao BS, Wang K., et al. Antithombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts. Proc Natl Acad Sci USA 2007 ; 104: 11915-11920.
19. Perren SM and Cordey J. The concept of interfragmentary strain. In: Uhthoff HK. (ed) Current concepts of internal fixation of fractures. Berlin: Springer-Verlag, 63-77, 1980.
20. Murray DW and Rushton N. The effect of strain on bone cell prostaglandin E2 release: a new experimental method. Calcif Tissue Int 1990 ; 47: 35-39.
21. Neidlinger-Wilke C., Stalla I., Claes L., Brand R., Hoellen I., Rubenacker S., et al. |Human osteoblasts from younger normal and osteoporotic donors show differences in proliferation and TGFβ release in response to cyclic strain. J Biomech 1995 ; 28: 1411-1418.
22. Brand RA, Stanford CM and Nicolella DP Primary adult human bone cells do not respond to tissue (continuum) level strains. J Orthop Sci 2001 ; 6: 295-301.
23. Qi MC, Hu J., Zou SJ, Chen HQ, Zhou HX and Han LC Mechanical strain induces osteogenic differentiation: Cbfa1 and Ets-1 expression in stretched rat mesenchymal stem cells. Int J Oral Maxillofac Surg 2008 ; 37: 453-458.
24. Scaglione S., Wendt D., Miggino S., Papadimitropoulos A., Fata M., Quarto R., et al. Effects of fluid flow and calcium phosphate coating on human bone marrow stromal cells cultured in a defined 2D model system. J Biomed Mater Res A 2008 ; 86: 411-419.
25. Zhong SP, Teo WE, Zhu X., Beuerman RW, Ramakrishna S. and Yung LYL. An aligned nanofibrous collagen scaffold by electrospinning and its effects on in vitro fibroblast culture. J Biomed Mater Res 2006 ; 79A: 456-463.
26. Kurpinski K., Chu J., Hashi C. and Li S. Anisotropic mechanosensing by mesenchymal stem cells. Proc Natl Acad Sci USA 2006 ; 103: 16095-16100.
27. Lee CH, Shin HJ, Cho IH, Kang YM, Kim IA, Park KD, et al. Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials 2005 ; 26: 1261-1270.
28. Park JS, Chu JSF, Cheng C., Chen FQ, Chen D. and Li S. Differential effects of equiaxial and uniaxial strain on mesenchymal stem cells. Biotechnol Bioeng 2004 ; 88: 359-368.
29. Hayakawa K., Sato N. and Obinata T. Dynamic reorientation of cultured cells and stress fibers under mechanical stress from periodic stretching. Exp Cell Res 2001 ; 268: 104-114.
30. Elias KL, Price RL and Webster TJ Enhanced functions of osteoblasts on nanometer diameter carbon fibers. Biomaterials 2002 ; 23: 3279-3287.
31. Simmons CA, Matlis S., Thornton AJ, Chen SQ, Wang CY and Mooney DJ Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech 2003 ; 36: 1087-1096.
32. Burger EH and Veldhuijzen JP Influence of mechanical factors on bone formation, resorption, and growth in vitro. In: Hall BK. (ed) Bone: bone growth-B. Florida: CRC Press, 1993, Vol. 7, pp. 37-56.
33. Xu M., Yan Y., Liu H., Yao R. and Wang X. Controlled adipose-derived stromal cells differentiation into adipose and endothelial cells in a 3D structure established by cell-assembly technique. J Bioact Compat Polym 2009 ; 24: 31-47.
34. Tian F., Hosseinkhani H., Hosseinkhani M., Khademhosseini A., Yokoyama Y., Estrada GG, et al. Quantitative analysis of cell adhesion on aligned micro- and nanofibers. J Biomed Mater Res 84A: 291-299.
35. Xu CY, Inai R., Kotaki M. and Ramakrishna S. Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering. Biomaterials 2004 ; 25: 877-886.
36. Kaspar D., Seidl W., Neidlinger-Wilke C., Ignatius A. and Claes L. Dynamic cell stretching increases human osteoblast proliferation and CICP synthesis but decreases osteocalcin synthesis and alkaline phosphatase activity. J Biomech 2000 ; 33: 45-51.
37. Fedarko NS, Bianco P., Vetter U. and Robey PG Human bone cell enzyme expression and cellular heterogeneity: correlation of alkaline phosphatase enzyme activity with cell cycle. J Cell Physiol 1990 ; 144: 115-121.
38. Pfeiler TW, Sumanasinghe RD and Loboa EG Finite element modeling of 3D human mesenchymal stem cell-seeded collagen matrices exposed to tensile strain. J Biomech 2008 ; 41: 2289-2296.