Estimating the risk of HIV transmission from homosexual men receiving treatment to their HIV-uninfected partners

Sexually Transmitted Infections

Volumn 87, Issue 1, 2011, Pages 17-21

  Hallett, Timothy B ^a   Smit, Colette ^b   Garnett, Geoff P ^a   De Wolf, Frank ^a,b,c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b STICHTING HIV MONITORING   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRAL THERAPY; ARTICLE; CONDOM; HIGH RISK BEHAVIOR; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; MALE; MALE HOMOSEXUAL; MATHEMATICAL MODEL; NETHERLANDS; PATIENT MONITORING; PRIORITY JOURNAL; PROBABILITY; RISK ASSESSMENT; RISK REDUCTION; SEXUAL INTERCOURSE; SIMULATION; VIRUS LOAD; VIRUS TRANSMISSION;

ANTI-HIV AGENTS; CONDOMS; EPIDEMIOLOGIC METHODS; HIV INFECTIONS; HOMOSEXUALITY, MALE; HUMANS; MALE; SEXUAL PARTNERS; VIRAL LOAD;

EID: 78751669179     PISSN: 13684973     EISSN: None     Source Type: Journal    
DOI: 10.1136/sti.2010.042622     Document Type: Article

References (29)

1. Hammer SM, Squires KE, Hughes MD, et al. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med 1997;337:725-33.
2. Staszewski S, Morales-Ramirez J, Tashima KT, et al. Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team. N Engl J Med 1999;341:1865-73.
3. UNAIDS. Report on the Global AIDS epidemic, http://www.unaids.org/en/ knowledge/HIVdata/globalreport/2008/2008-global-report.asp, 2008.
4. Jahn A, Floyd S, Crampin AC, et al. Population-level effect of HIV on adult mortality and early evidence of reversal after introduction of antiretroviral therapy in Malawi. Lancet 2008;371:1603-11.
5. When To Start Consortium, Sterne JA, May M, Costagliola D, et al. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet 2009;373:1352-63.
6. Montaner JS, Hogg R, Wood E, et al. The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. Lancet 2006;368:531-6. (Pubitemid 44142776)
7. Granich RM, Gilks CF, Dye C, et al. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 2009;373:48-57.
8. Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med 2000;342:921-9.
9. Vernazza P, Hirschel B, Bernasconi E, et al. Les personnes séropositives ne souffrant d'aucune autre MST et suivant un traitement antirétroviral efficace ne transmettent pas le VIH par voie sexuelle. Bulletin des médecins suisses 2008;89:165-9.
10. Vernazza PL. The debate continues: does 'undetectable' mean 'uninfectious'? HIV ther 2009;3:113-16.
11. National Association of People Living With HIV/AIDS 2008. AIDS 2008: The Swiss Statement- the debate continues, 2009. Available at http://napwa.org.au/ pl/2008/09/aids-2008-the-swiss-statement-the-debate-continues (accessed 29 June 2010).
12. Sturmer M, Doerr HW, Berger A, et al. Is transmission of HIV-1 in non-viraemic serodiscordant couples possible? Antivir Ther 2008;13:729-32.
13. Wilson DP, Law MG, Grulich AE, et al. Relation between HIV viral load and infectiousness: a model-based analysis. Lancet 2008;372:314-20.
14. Garnett GP, Gazzard B. Risk of HIV transmission in discordant couples. Lancet 2008;372:270-1.
15. Attia S, Egger M, Muller M, et al. Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis. Aids 2009;23:1397-404.
16. Wilson DP. Data are lacking for quantifying HIV transmission risk in the presence of effective antiretroviral therapy. Aids 2009;23:1431-3.
17. van Sighem AI, van de Wiel MA, Ghani AC, et al. Mortality and progression to AIDS after starting highly active antiretroviral therapy. Aids 2003;17:2227-36.
18. Hallett TB, Gregson S, Dube S, et al. The impact of monitoring HIV patients prior to treatment in resource-poor settings: insights from mathematical modelling. PLoS Med 2008;5:e53.
19. Smit C, Hallett TB, Lange J, et al. Late entry to HIV care limits the impact of antiretroviral therapy in The Netherlands. PLoS One 2008;3:e1949.
20. Fraser C, Hollingsworth TD, Chapman R, et al. Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis. Proc Natl Acad Sci U S A 2007;104:17441-6.
21. Braithwaite RS, Justice AC, Chang CC, et al. Estimating the proportion of patients infected with HIV who will die of comorbid diseases. Am J Med 2005;118:890-8.
22. Centers for Disease Control and Prevention. http://www.cdc.gov/hiv/, 2008.
23. Ndiaye B, Ould-Kaci K, Salleron J, et al. Characteristics of and outcomes in HIV-infected patients who return to care after loss to follow-up. AIDS 2009;23:1786-9.
24. Stolte IG, de Wit JB, van EA, et al. Perceived viral load, but not actual HIV-1-RNA load, is associated with sexual risk behaviour among HIV-infected homosexual men. AIDS 2004;18:1943-9.
25. Hirschel B. Meal. How reliable is an undetectable viral load (VL)? The past as a guide to the future. XVII International AIDS conference. Mexico City: 2008.
26. Vittinghoff E, Douglas J, Judson F, et al. Per-contact risk of human immunodeficiency virus transmission between male sexual partners. Am J Epidemiol 1999;150:306-11.
27. Koblin BA, Husnik MJ, Colfax G, et al. Risk factors for HIV infection among men who have sex with men. Aids 2006;20:731-9.
28. Podsadecki TJ, Vrijens BC, Tousset EP, et al. Decreased adherence to antiretroviral therapy observed prior to transient human immunodeficiency virus type 1 viremia. J Infect Dis 2007;196:1773-8.
29. Wasserfallen F, SRWH. Swiss Statement for PLWHA on effective ARV treatment. XVII International AIDS conference. Mexico City: 2008.