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Volumn 33, Issue 1, 2011, Pages 94-98

Light transmittance aggregometry induced by different concentrations of adenosine diphosphate to monitor clopidogrel therapy: A methodological study

Author keywords

clopidogrel; platelet aggregation; platelet function testing; response variability; standardization of methodology

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; CLOPIDOGREL; PURINERGIC P2Y12 RECEPTOR;

EID: 78751649249     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e3182052ff4     Document Type: Article
Times cited : (17)

References (39)
  • 1
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pre-treatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study
    • Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators
    • Mehta SR, Yusuf S, Peters RJ, et al. Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Effects of pre-treatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358:527-533.
    • (2001) Lancet , vol.358 , pp. 527-533
    • Mehta, S.R.1    Yusuf, S.2    Peters, R.J.3
  • 2
    • 0037145863 scopus 로고    scopus 로고
    • Clopidogrel for the reduction of events during observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • Steinhubl SR, Berger PB, Mann JT 3rd, et al. Clopidogrel for the reduction of events during observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA. 2002;288:2411-2420.
    • (2002) JAMA , vol.288 , pp. 2411-2420
    • Steinhubl, S.R.1    Berger, P.B.2    Mann III, J.T.3
  • 3
    • 34250020766 scopus 로고    scopus 로고
    • Impact of platelet reactivity following clopidogrel administration on drug-eluting
    • Buonamici P, Marcucci R, Migliorini A, et al. Impact of platelet reactivity following clopidogrel administration on drug-eluting. J Am Coll Cardiol. 2007;49:2312-2317.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 2312-2317
    • Buonamici, P.1    Marcucci, R.2    Migliorini, A.3
  • 4
    • 35248878504 scopus 로고    scopus 로고
    • Residual platelet reactivity is associated with clinical and laboratory characteristics in patients with ischemic heart disease undergoing PCI on dual antiplatelet therapy
    • Marcucci R, Gori AM, Paniccia R, et al. Residual platelet reactivity is associated with clinical and laboratory characteristics in patients with ischemic heart disease undergoing PCI on dual antiplatelet therapy. Atherosclerosis. 2007;195:e217-e223.
    • (2007) Atherosclerosis , vol.195
    • Marcucci, R.1    Gori, A.M.2    Paniccia, R.3
  • 5
    • 59849120163 scopus 로고    scopus 로고
    • Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: A 12-month follow-up
    • Marcucci R, Gori AM, Paniccia R, et al. Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up. Circulation. 2009;119:237-242.
    • (2009) Circulation , vol.119 , pp. 237-242
    • Marcucci, R.1    Gori, A.M.2    Paniccia, R.3
  • 6
    • 34447576539 scopus 로고    scopus 로고
    • Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: A systematic review and meta-analysis
    • Snoep JD, Hovens MM, Eikenboom JC, et al. Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis. Am Heart J. 2007;154:221-231.
    • (2007) Am Heart J , vol.154 , pp. 221-231
    • Snoep, J.D.1    Hovens, M.M.2    Eikenboom, J.C.3
  • 7
    • 60949083948 scopus 로고    scopus 로고
    • Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis
    • Sibbing D, Braun S, Morath T, et al. Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J Am Coll Cardiol. 2009;53:849-856.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 849-856
    • Sibbing, D.1    Braun, S.2    Morath, T.3
  • 8
    • 77953911457 scopus 로고    scopus 로고
    • Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate
    • Bonello L, Tantry US, Marcucci R, et al. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol. 2010;56:919-933.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 919-933
    • Bonello, L.1    Tantry, U.S.2    Marcucci, R.3
  • 9
    • 17144370263 scopus 로고    scopus 로고
    • Resistance to clopidogrel: A review of the evidence
    • Nguyen TA, Diodati JG, Pharand C. Resistance to clopidogrel: a review of the evidence. J Am Coll Cardiol. 2005;45:1157-1164.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1157-1164
    • Nguyen, T.A.1    Diodati, J.G.2    Pharand, C.3
  • 10
    • 67749117943 scopus 로고    scopus 로고
    • Clopidogrel response variability: Current status and future directions
    • Ferreiro JL, Angiolillo DJ. Clopidogrel response variability: current status and future directions. Thromb Haemost. 2009;102:7-14.
    • (2009) Thromb Haemost , vol.102 , pp. 7-14
    • Ferreiro, J.L.1    Angiolillo, D.J.2
  • 11
    • 71949115114 scopus 로고    scopus 로고
    • Relation of body mass index to high on-treatment platelet reactivity and of failed clopidogrel dose adjustment according to platelet reactivity monitoring in patients undergoing percutaneous coronary intervention
    • Bonellopalot N, Armero S, Paganelli F, et al. Relation of body mass index to high on-treatment platelet reactivity and of failed clopidogrel dose adjustment according to platelet reactivity monitoring in patients undergoing percutaneous coronary intervention. Am J Cardiol. 2009; 104:1511-1515.
    • (2009) Am J Cardiol , vol.104 , pp. 1511-1515
    • Bonellopalot, N.1    Armero, S.2    Paganelli, F.3
  • 12
    • 43049179414 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 681G.A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents
    • Trenk D, Hochholzer W, Fromm MF, et al. Cytochrome P450 2C19 681G.A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents. J Am Coll Cardiol. 2008;51:1925-1934.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1925-1934
    • Trenk, D.1    Hochholzer, W.2    Fromm, M.F.3
  • 13
    • 38449103046 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients
    • Giusti B, Gori AM, Marcucci R, et al. Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients. Pharmacogenet Genomics 2007;17:1057-1064.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 1057-1064
    • Giusti, B.1    Gori, A.M.2    Marcucci, R.3
  • 14
    • 77949894946 scopus 로고    scopus 로고
    • Relation of CYP2C19 loss-of-function polymorphism to the occurrence of stent thrombosis
    • Giusti B, Gori AM, Marcucci R, et al. Relation of CYP2C19 loss-of-function polymorphism to the occurrence of stent thrombosis. Expert Opin Drug Metab Toxicol. 2010;6:393-407.
    • (2010) Expert Opin Drug Metab Toxicol , vol.6 , pp. 393-407
    • Giusti, B.1    Gori, A.M.2    Marcucci, R.3
  • 15
    • 77952591958 scopus 로고    scopus 로고
    • Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement
    • Hochholzer W, Trenk D, Fromm MF, et al. Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement. J Am Coll Cardiol. 2010;55:2427-2434.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2427-2434
    • Hochholzer, W.1    Trenk, D.2    Fromm, M.F.3
  • 16
    • 0037422534 scopus 로고    scopus 로고
    • Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drug-drug interaction
    • Lau WC, Waskell LA, Watkins PB, et al. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction. Circulation. 2003;107:32-37.
    • (2003) Circulation , vol.107 , pp. 32-37
    • Lau, W.C.1    Waskell, L.A.2    Watkins, P.B.3
  • 17
    • 46849109542 scopus 로고    scopus 로고
    • Coexisting polymorphisms of P2Y12 and CYP2C19 genes as a risk factor for persistent platelet activation with clopidogrel
    • Malek LA, Kisiel B, Spiewak M, et al. Coexisting polymorphisms of P2Y12 and CYP2C19 genes as a risk factor for persistent platelet activation with clopidogrel. Circ J. 2008;72:1165-1169.
    • (2008) Circ J , vol.72 , pp. 1165-1169
    • Malek, L.A.1    Kisiel, B.2    Spiewak, M.3
  • 18
    • 8344221349 scopus 로고    scopus 로고
    • Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction
    • Matetzky S, Shenkman B, Guetta V, et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation. 2004;109: 3171-3175.
    • (2004) Circulation , vol.109 , pp. 3171-3175
    • Matetzky, S.1    Shenkman, B.2    Guetta, V.3
  • 19
    • 33947495459 scopus 로고    scopus 로고
    • High post-treatment platelet reactivity is associated with a high incidence of myonecrosis after stenting for non-ST elevation acute coronary syndromes
    • Cuisset T, Frere C, Quilici J, et al. High post-treatment platelet reactivity is associated with a high incidence of myonecrosis after stenting for non-ST elevation acute coronary syndromes. Thromb Haemost. 2007;97:282-287.
    • (2007) Thromb Haemost , vol.97 , pp. 282-287
    • Cuisset, T.1    Frere, C.2    Quilici, J.3
  • 20
    • 33750985116 scopus 로고    scopus 로고
    • Platelet hyperactivity and risk of recurrent thrombosis
    • Harrison P, Keeling D. Platelet hyperactivity and risk of recurrent thrombosis. J Thromb Haemost. 2006;4:2544-2546.
    • (2006) J Thromb Haemost , vol.4 , pp. 2544-2546
    • Harrison, P.1    Keeling, D.2
  • 21
    • 35549008493 scopus 로고    scopus 로고
    • Platelet function monitoring in patients with coronary artery disease
    • Gurbel PA, Becker RC, Mann KG, et al. Platelet function monitoring in patients with coronary artery disease. J Am Coll Cardiol. 2007;50: 1822-18234.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1822-18234
    • Gurbel, P.A.1    Becker, R.C.2    Mann, K.G.3
  • 22
    • 58249142988 scopus 로고    scopus 로고
    • Methods for the measurement of platelet function
    • Michelson AD. Methods for the measurement of platelet function. Am J Cardiol. 2009;103:A20-A26.
    • (2009) Am J Cardiol , vol.103
    • Michelson, A.D.1
  • 23
    • 70249101426 scopus 로고    scopus 로고
    • Results of a Worldwide Survey on the Assessment of Platelet Function by Light Transmission Aggregometry Scientific and Standardization Committee Communications: on behalf of the Platelet Physiology Subcommittee of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis
    • Cattaneo M, Hayward CPM, Moffat KA, et al. Results of a Worldwide Survey on the Assessment of Platelet Function by Light Transmission Aggregometry Scientific and Standardization Committee Communications: on behalf of the Platelet Physiology Subcommittee of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis. J Thromb Haemost. 2009;7:1029.
    • (2009) J Thromb Haemost , vol.7 , pp. 1029
    • Cattaneo, M.1    Hayward, C.P.M.2    Moffat, K.A.3
  • 24
    • 69349095420 scopus 로고    scopus 로고
    • Clinical and Laboratory standards Institute (CLSI) CLSI document H58-A (ISBN 1-56238-683-2). Wayne, PA: Clinical and Laboratory Standards Institute Available at
    • Clinical and Laboratory standards Institute (CLSI). Platelet Function Testing by Aggregometry: Approved Guideline. CLSI document H58-A (ISBN 1-56238-683-2). Wayne, PA: Clinical and Laboratory Standards Institute 2008. Available at: www.clsi.org.
    • (2008) Platelet Function Testing by Aggregometry: Approved Guideline
  • 25
    • 15344344771 scopus 로고    scopus 로고
    • Variability in clinical laboratory practice in testing for disorders of platelet function
    • Results of two surveys of the North American Specialized Coagulation Laboratory Association
    • Moffat KA, Ledford-Kraemer MR, Nichols WL, et al. Variability in clinical laboratory practice in testing for disorders of platelet function. Results of two surveys of the North American Specialized Coagulation Laboratory Association. Thromb Haemost. 2005;93:549-553.
    • (2005) Thromb Haemost , vol.93 , pp. 549-553
    • Moffat, K.A.1    Ledford-Kraemer, M.R.2    Nichols, W.L.3
  • 26
    • 35548957533 scopus 로고    scopus 로고
    • Assessment of clopidogrel responsiveness: Measurements of maximum platelet aggregation, final platelet aggregation and their correlation with vasodilator-stimulated phosphoprotein in resistant patients
    • Gurbel PA, Bliden KP, Etherington A, et al. Assessment of clopidogrel responsiveness: measurements of maximum platelet aggregation, final platelet aggregation and their correlation with vasodilator-stimulated phosphoprotein in resistant patients. Thromb Res. 2007;121:107-115.
    • (2007) Thromb Res , vol.121 , pp. 107-115
    • Gurbel, P.A.1    Bliden, K.P.2    Etherington, A.3
  • 27
    • 34249939815 scopus 로고    scopus 로고
    • Measuring antiplatelet drug effects in the laboratory
    • Harrison P, Frelinger AL 3rd, Furman MI, et al. Measuring antiplatelet drug effects in the laboratory. Thromb Res. 2007;120:323-336.
    • (2007) Thromb Res , vol.120 , pp. 323-336
    • Harrison, P.1    Frelinger Iii, A.L.2    Furman, M.I.3
  • 28
    • 34147100223 scopus 로고    scopus 로고
    • Evaluation of the platelet response to clopidogrel with light transmittance aggregometry: Peak aggregation or late aggregation?
    • van Werkum JW, Kleibeuker M, Mieremet N, et al. Evaluation of the platelet response to clopidogrel with light transmittance aggregometry: peak aggregation or late aggregation? J Thromb Haemost. 2007;5: 884-886.
    • (2007) J Thromb Haemost , vol.5 , pp. 884-886
    • Van Werkum, J.W.1    Kleibeuker, M.2    Mieremet, N.3
  • 29
    • 21344442173 scopus 로고    scopus 로고
    • Can platelet aggregometry be standardized?
    • Breddin HK. Can platelet aggregometry be standardized? Platelets. 2005; 16:151-158.
    • (2005) Platelets , vol.16 , pp. 151-158
    • Breddin, H.K.1
  • 30
    • 0346367328 scopus 로고
    • Aggregation of blood platelets by adenosine diphosphate and its reversal
    • Born GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962;194:927-929.
    • (1962) Nature , vol.194 , pp. 927-929
    • Born, G.V.1
  • 31
    • 34548075511 scopus 로고    scopus 로고
    • Different methodologies for evaluating the effect of clopidogrel on platelet function in high-risk coronary artery disease patients
    • Paniccia R, Antonucci E, Gori AM, et al. Different methodologies for evaluating the effect of clopidogrel on platelet function in high-risk coronary artery disease patients. J Thromb Haemost. 2007;5:1839-1847.
    • (2007) J Thromb Haemost , vol.5 , pp. 1839-1847
    • Paniccia, R.1    Antonucci, E.2    Gori, A.M.3
  • 32
    • 0033537494 scopus 로고    scopus 로고
    • Rapid platelet-function assay: An automated and quantitative cartridge-based method
    • Smith JW, Steinhubl SR, Lincoff AM, et al. Rapid platelet-function assay: an automated and quantitative cartridge-based method. Circulation. 1999; 99:620-625.
    • (1999) Circulation , vol.99 , pp. 620-625
    • Smith, J.W.1    Steinhubl, S.R.2    Lincoff, A.M.3
  • 33
    • 18144371221 scopus 로고    scopus 로고
    • The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting
    • Gurbel PA, Bliden KP, Hayes KM, et al. The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting. J Am Coll Cardiol. 2005;3:1392-1396.
    • (2005) J Am Coll Cardiol , vol.3 , pp. 1392-1396
    • Gurbel, P.A.1    Bliden, K.P.2    Hayes, K.M.3
  • 34
    • 35048856897 scopus 로고    scopus 로고
    • ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome
    • Frere C, Cuisset T, Quilici J, et al. ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome. Thromb Haemost. 2007;98:838-843.
    • (2007) Thromb Haemost , vol.98 , pp. 838-843
    • Frere, C.1    Cuisset, T.2    Quilici, J.3
  • 35
    • 67649372663 scopus 로고    scopus 로고
    • Assessment, mechanisms, and clinical implication of variability in platelet response to aspirin and clopidogrel therapy
    • Ben-Dor I, Kleiman NS, Lev E. Assessment, mechanisms, and clinical implication of variability in platelet response to aspirin and clopidogrel therapy. Am J Cardiol. 2009;104:227-233.
    • (2009) Am J Cardiol , vol.104 , pp. 227-233
    • Ben-Dor, I.1    Kleiman, N.S.2    Lev, E.3
  • 36
    • 67149089211 scopus 로고    scopus 로고
    • Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy
    • Paniccia R, Antonucci E, Maggini N, et al. Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy. Am J Clin Pathol. 2009;131:834-842.
    • (2009) Am J Clin Pathol , vol.131 , pp. 834-842
    • Paniccia, R.1    Antonucci, E.2    Maggini, N.3
  • 37
    • 77955449383 scopus 로고    scopus 로고
    • Comparison of methods for monitoring residual platelet reactivity after clopidogrel by point-of-care tests on whole blood in high-risk patients
    • Paniccia R, Antonucci E, Maggini N, et al. Comparison of methods for monitoring residual platelet reactivity after clopidogrel by point-of-care tests on whole blood in high-risk patients. Thromb Haemost. 2010;104: 287-292.
    • (2010) Thromb Haemost , vol.104 , pp. 287-292
    • Paniccia, R.1    Antonucci, E.2    Maggini, N.3
  • 38
    • 70349857877 scopus 로고    scopus 로고
    • Insights into the interpretation of light transmission aggregometry for evaluation of platelet aggregation inhibition by clopidogrel
    • Lordkipanidzé M, Pharand C, Palisaitis DA, et al. Insights into the interpretation of light transmission aggregometry for evaluation of platelet aggregation inhibition by clopidogrel. Thromb Res. 2009;124:546-553.
    • (2009) Thromb Res , vol.124 , pp. 546-553
    • Lordkipanidzé, M.1    Pharand, C.2    Palisaitis, D.A.3
  • 39
    • 67650745975 scopus 로고    scopus 로고
    • Intensifying platelet inhibition with tirofiban in poor responders to aspirin, clopidogrel, or both agents undergoing elective coronary intervention. Results from the double-blind, prospective, randomized tailoring treatment with tirofiban in patients showing resistance to aspirin and/or resistance to clopidogrel study
    • Valgimigli M, Campo G, de Cesare N, et al. Intensifying platelet inhibition with tirofiban in poor responders to aspirin, clopidogrel, or both agents undergoing elective coronary intervention. Results from the double-blind, prospective, randomized tailoring treatment with tirofiban in patients showing resistance to aspirin and/or resistance to clopidogrel study. Circulation. 2009;119:3215-3222.
    • (2009) Circulation , vol.119 , pp. 3215-3222
    • Valgimigli, M.1    Campo, G.2    De Cesare, N.3


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