Amino acid substitutions in an alpha-helical antimicrobial arachnid peptide affect its chemical properties and biological activity towards pathogenic bacteria but improves its therapeutic index

Amino Acids

Volumn 40, Issue 1, 2011, Pages 61-68

  Rodriguez A ^a   Villegas, E ^b   Satake, H ^c   Possani, L D ^a   Corzo, Gerardo ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^c SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

Antimicrobial peptide; Arachnid, pandinin 2; Peptide synthesis; S. aureus

Indexed keywords

GLYCINE; PANDININ 2; POLYPEPTIDE ANTIBIOTIC AGENT; PROLINE; UNCLASSIFIED DRUG; VALINE;

AGAR DIFFUSION; ALPHA HELIX; AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; ARACHNID; ARTICLE; BACILLUS SUBTILIS; BIOLOGICAL ACTIVITY; CHEMICAL REACTION; CONTROLLED STUDY; CULTURE MEDIUM; ESCHERICHIA COLI; HEMOLYSIS; HYDROPHOBICITY; LISTERIA MONOCYTOGENES; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN VARIANT; SALMONELLA TYPHI; SHIGELLA FLEXNERI; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS AGALACTIAE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTI-BACTERIAL AGENTS; GRAM-POSITIVE BACTERIA; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; SCORPIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

ARACHNIDA; ARANEAE; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 78751577575     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-009-0449-y     Document Type: Article

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