A prospective randomized noninferiority study comparing recombinant FSH and highly purified menotropin in intrauterine insemination cycles in couples with unexplained infertility and/or mild-moderate male factor

Fertility and Sterility

Volumn 95, Issue 2, 2011, Pages 689-694

  Sagnella, Francesca ^a   Moro, Francesca ^a   Lanzone, Antonio ^b   Tropea, Anna ^a   Martinez, Daniela ^a   Capalbo, Antonio ^a   Gangale, Maria Francesca ^a   Spadoni, Valentina ^a   Morciano, Andrea ^a   Apa, Rosanna ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b OASI RESEARCH INSTITUTE IRCCS   (Italy)

Author keywords

HP hMG; infertility; IUI; ovulation induction; rFSH

Indexed keywords

CHORIONIC GONADOTROPIN; HUMAN MENOPAUSAL GONADOTROPIN; MEROPUR; RECOMBINANT FOLLITROPIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FEMALE INFERTILITY; HUMAN; INTRAUTERINE INSEMINATION; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; MULTIPLE PREGNANCY; OUTCOME ASSESSMENT; OVARY HYPERSTIMULATION; PREGNANCY RATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT;

ADULT; ALGORITHMS; FAMILY CHARACTERISTICS; FEMALE; FERTILITY AGENTS, FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; INFERTILITY; INFERTILITY, MALE; INSEMINATION, ARTIFICIAL; MALE; MENOTROPINS; MENSTRUAL CYCLE; PREGNANCY; PREGNANCY RATE; RECOMBINANT PROTEINS; SEVERITY OF ILLNESS INDEX; UTERUS;

EID: 78751572787     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2010.08.044     Document Type: Article

References (27)

1. E.G. Hughes The effectiveness of ovulation induction and intrauterine insemination in the treatment of persistent infertility: a meta-analysis Human Reprod 12 1997 1865 1872
2. B.J. Cohlen Should we continue performing intrauterine insemination in the year 2004? Gynecol Obstet Invest 59 2005 3 13
3. K. Zikopoulos, C.P. West, P.W. Thong, E.M. Kacser, J. Morrison, and F.C. Wu Homologous intra-uterine insemination has no advantage over timed natural intercourse when used in combination with ovulation induction for the treatment of unexplained infertility Hum Reprod 8 1993 563 567
4. H.B. Zeyneloglu, A. Arici, D.L. Olive, and A.J. Duleba Comparison of intrauterine insemination with timed intercourse in superovulated cycles with gonadotropins: a meta-analysis Fertil Steril 69 1998 486 491
5. D.S. Guzick, S.A. Carson, C. Coutifaris, J.W. Overstreet, P. Factor-Litvak, M.P. Steinkampf National Cooperative Reproductive Medicine Network Efficacy of superovulation and intrauterine insemination in the treatment of infertility N Engl J Med 340 1999 177 183
6. M.F. Costello Systematic review of treatment of ovulatory infertility with clomiphene citrate and intrauterine insemination Aust N Z J Obstet Gynaecol 44 2004 93 102
7. J.S. Cunha-Filho, J. Kadoch, C. Righini, R. Fanchin, R. Frydman, and F. Olivennes Premature LH and progesterone rise in intrauterine insemination cycles: analysis of related factors Reprod Biomed Online 7 2003 194 199
8. P.O. Karlström, T. Bergh, and O. Lundkvist A prospective randomized trial of artificial insemination versus intercourse in cycles stimulated with human menopausal gonadotropin or clomiphene citrate Fertil Steril 59 1993 554 559
9. R. Fanchin, F. Olivennes, C. Righini, A. Hazout, B. Schwab, and R. Frydman A new system for fallopian tube sperm perfusion leads to pregnancy rates twice as high as standard intrauterine insemination Fertil Steril 64 1995 505 510
10. Z. Kilani, A. Dakkak, S. Ghunaim, G.E. Cognini, C. Tabarelli, and L. Parmegiani A prospective, randomized, controlled trial comparing highly purified hMG with recombinant FSH in women undergoing ICSI: ovarian response and clinical outcomes Hum Reprod 18 2003 1194 1199
11. H.G. Al-Inany, A.M. Abou-Setta, M.A. Aboulghar, R.T. Mansour, and G.I. Serour Efficacy and safety of human menopausal gonadotrophins versus recombinant FSH: a meta-analysis Reprod Biomed Online 16 2008 81 88
12. J. Balasch, J.L. Ballesca, C. Pimentel, M. Creus, F. Fabregues, and J.A. Vanrell Late low-dose pure follicle stimulating hormone for ovarian stimulation in intra-uterine insemination cycles Hum Reprod 9 1994 1863 1866
13. R. Matorras, V. Recio, B. Corcóstegui, and F.J. Rodríguez-Escudero Recombinant human FSH versus highly purified urinary FSH: a randomized study inintrauterine insemination with husbands" spermatozoa Hum Reprod 15 2000 1231 1234
14. A. Demirol, and T. Gurgan Comparison of different gonadotrophin preparations in intrauterine insemination cycles for the treatment of unexplained infertility: a prospective, randomized study Hum Reprod 22 2007 97 100
15. J. Wechowski, M. Connolly, D. Schneider, P. McEwan, and R. Kennedy Cost-saving treatment strategies in in vitro fertilization: a combined economic evaluation of two large randomized clinical trials comparing highly purified human menopausal gonadotropin and recombinant follicle-stimulating hormone alpha Fertil Steril 91 2009 1067 1076
16. D.G. Altman, and C.J. Doré Baseline comparisons in randomized clinical trials Stat Med 10 1991 797 799
17. M. Filicori, G.E. Cognini, P. Pocognoli, C. Tabarelli, F. Ferlini, and T. Perri Comparison of controlled ovarian stimulation with human menopausal gonadotropin or recombinant follicle-stimulating hormone Fertil Steril 80 2003 390 397
18. E. Bosch, C. Vidal, E. Labarta, C. Simon, J. Remohi, and A. Pellicer Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists - a randomized study Hum Reprod 23 2008 2346 2351
19. A.N. Andersen, P. Devroey, and J.C. Arce Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial Hum Reprod 21 2006 3217 3227
20. P. Platteau, A.N. Andersen, A. Balen, P. Devroey, P. Sorensen, and L. Helmgaard Similar ovulation rates, but different follicular development with highly purified menotrophin compared with recombinant FSH in WHO group II anovulatory infertility: a randomized controlled study Hum Reprod 21 2006 1798 1804
21. E. Loumaye, P. Engrand, Z. Shoham, S.G. Hillier, and D.T. Baird Clinical evidence for an LH "ceiling" effect induced by administration of recombinant human LH during the late follicular phase of stimulated cycles in World Health Organization type I and type II anovulation Hum Reprod 18 2003 314 322
22. J. Smitz, A.N. Andersen, P. Devroey, and J.C. Arce Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant in IVF patients Hum Reprod 22 2007 676 687
23. E.R. Hernandez, A. Hurwitz, D.W. Payne, A.M. Dharmarajan, A.F. Purchio, and E.Y. Adashi Transforming growth factor-β1 inhibits ovarian androgen production: gene expression, cellular localization, mechanism(s), and site(s) of action Endocrinology 127 1990 2804 2811
24. N. Fournet, S.R. Weitsman, R.J. Zachow, and D.A. Magoffin Transforming growth factor-β inhibits ovarian 17 α-hydroxylase activity by direct noncompetitive mechanism Endocrinology 137 1996 166 174
25. P. Platteau, J. Smitz, C. Albano, P. Sorensen, J.C. Arce, and P. Devroey Exogenous luteinizing hormone activity may influence the treatment outcome in in vitro fertilization but not in intracytoplasmic sperm injection cycles Fertil Steril 81 2004 1401 1404
26. F. Lisi, L. Rinaldi, S. Fishel, R. Lisi, G. Pepe, and M.G. Picconeri Use of recombinant FSH and recombinant LH in multiple follicular stimulation for IVF: a preliminary study Reprod Biomed Online 3 2001 190 194
27. A.P. Ferraretti, L. Gianaroli, M.C. Magli, A. d'Angelo, V. Farfalli, and N. Montanaro Exogenous luteinizing hormone in controlled ovarian hyperstimulation for assisted reproduction techniques Fertil Steril 82 2004 1521 1526