Teladorsagia circumcincta: The transcriptomic response of a multi-drug-resistant isolate to ivermectin exposure in vitro

Experimental Parasitology

Volumn 127, Issue 2, 2011, Pages 351-356

  Dicker, Alison J ^a,b   Nath, Mintu ^c   Yaga, Raja ^a   Nisbet, Alasdair J ^a   Lainson, F Alex ^a   Gilleard, John S ^d   Skuce, Philip J ^a  

^a MOREDUN RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c BIOMATHEMATICS AND STATISTICS SCOTLAND   (United Kingdom)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

Anthelmintic resistance; Gene expression; Ivermectin; Next generation sequencing; Teladorsagia circumcincta

Indexed keywords

CYTOCHROME C OXIDASE; CYTOCHROME P450; GLYCOPROTEIN P; IVERMECTIN; NICOTINIC RECEPTOR;

AMINO ACID METABOLISM; ANTHELMINTIC ACTIVITY; ARTICLE; BASE PAIRING; BIOINFORMATICS; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; EXPRESSED SEQUENCE TAG; GENE CLUSTER; GENE EXPRESSION PROFILING; IN VITRO STUDY; NEMATODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TELADORSAGIA CIRCUMCINCTA; XENOBIOTIC METABOLISM;

ANIMALS; ANTHELMINTICS; ANTIPARASITIC AGENTS; CLUSTER ANALYSIS; DRUG RESISTANCE, MULTIPLE; EXPRESSED SEQUENCE TAGS; FEMALE; GENE EXPRESSION PROFILING; IVERMECTIN; MALE; RNA, HELMINTH; SHEEP; TRICHOSTRONGYLOIDEA;

NEMATODA; TELADORSAGIA CIRCUMCINCTA;

EID: 78751567916     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2010.08.019     Document Type: Article

References (24)

1. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. Journal of Molecular Biology 1990, 215:403-410.
2. Bartley D.J., Jackson E., Johnston K., Coop R.L., Mitchell G.B.B., Sales J., Jackson F. A survey of anthelmintic resistant nematode parasites in Scottish sheep flocks. Veterinary Parasitology 2003, 117:61-71.
3. Bartley D.J., Jackson F., Jackson E., Sargison N. Characterisation of two triple resistant field isolates of Teladorsagia from Scottish lowland sheep farms. Veterinary Parasitology 2004, 123:189-199.
4. Benjamini Y., Hochberg Y. Controlling the false discovery rate - a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society Series B-Methodological 1995, 57:289-300.
5. Blake N., Coles G. Flock cull due to anthelmintic-resistant nematodes. Veterinary Record 2007, 161:36.
6. Britt D.P. Benzimidazole resistant nematodes in Britain. Veterinary Record 1982, 110:343-344.
7. Broughan J.M., Wall R. Faecal soiling and gastrointestinal helminth infection in lambs. International Journal for Parasitology 2007, 37:1255-1268.
8. Cawthorne R.J.G., Whitehead J.D. Isolation of benzimidazole resistant strains of Ostertagia circumcincta from British sheep. Veterinary Record 1983, 112:274-277.
9. Gilleard J.S. Understanding anthelmintic resistance. The need for genomics and genetics. International Journal for Parasitology 2006, 36:1227-1239.
10. Hong C., Hunt K.R., Coles G.C. Resistance to levamisole. Veterinary Record 1994, 135:535-536.
11. Jackson F., Coop R.L. The development of anthelmintic resistance in sheep nematodes. Parasitology 2000, 120:S95-S107.
12. Kotze A.C. Cytochrome P450 monooxygenase activity in Haemonchus contortus (Nematoda). International Journal for Parasitology 1997, 27:33-40.
13. Lindquist S. The heat-shock response. Annual Review of Biochemistry 1986, 55:1151-1191.
14. Marguiles M., Egholm M., Altman W.E., Attiya S., Bader J.S., Bemben L.A., Berka J., Braverman M.S., Chen Y.-J., Chen Z., Dewell S.B., Du L., Fierro J.M., Gomes X.V., Godwin B.C., He W., Helgesen S., Ho C.H., Irzyk G.P., Jando S.C., Alenquer M.L.I., Jarvie T.P., Jirage K.B., Kim J.-B., Knight J.R., Lanza J.R., Leamon J.H., Lefkowitz S.M., Lei M., Li J., Lohman K.L., Lu H., Makhijani V.B., McDade K.E., McKenna M.P., Myers E.W., Nickerson E., Nobile J.R., Plant R., Puc B.P., Ronan M.T., Roth G.T., Sarkis G.J., Simons J.F., Simpson J.W., Srinivasan M., Tartaro K.R., Tomasz A., Vogt K.A., Volkmer G.A., Wang S.H., Wang Y., Weiner M.P., Yu P., Begley R.F., Rothberg J.M. Genome sequencing in microfabricated high-density picolitre reactors. Nature 2005, 437:376-380.
15. Moriya Y., Itoh M., Okuda S., Yoshizawa A.C., Kanehisa M. KAAS: an automatic genome annotation and pathway reconstruction server. Nucleic Acids Research 2007, 35:W182-W185.
16. Nieuwhof G.J., Bishop S.C. Costs of the major endemic diseases of sheep in great Britain and the potential benefits of reduction in disease impact. Animal Science 2005, 81:23-29.
17. Nisbet A.J., Redmond D.L., Matthews J.B., Watkins C., Yaga R., Jones J.T., Nath M., Knox D.P. Stage-specific gene expression in Teladorsagia circumcincta (Nematoda: Strongylida) infective larvae and early parasitic stages. International Journal for Parasitology 2008, 38:829-838.
18. Payne R.W., Murray D.A., Harding S.A., Baird D.B., Souter D.M. GenStat for Windows 2009, VSN International.
19. Prichard R.K., Roulet A. ABC transporters and β-tubulin in macrocyclic lactone resistance: prospects for marker development. Parasitology 2007, 134:1123-1132.
20. Sargison N., Scott P., Jackson F. Multiple anthelmintic resistance in sheep. Veterinary Record 2001, 149:778-779.
21. Sargison N.D., Jackson F., Bartley D.J., Moir A.C.P. Failure of moxidectin to control benzimidazole-, levamisole- and ivermectin-resistant Teladorsagia circumcincta in a sheep flock. Veterinary Record 2005, 156:105-109.
22. Visser A., Van Zeveren A.M., Meyvis Y., Peelaers I., Van den Broeck W., Gevaert K., Vercruysse J., Claerebout E., Geldhof P. Gender-enriched transcription of activation associated secreted proteins in Ostertagia ostertagi. International Journal for Parasitology 2008, 38:455-465.
23. von Samson-Himmelstjerna G., Blackhall W.J., McCarthy J.S., Skuce P.J. Single nucleotide polymorphism (SNP) markers for benzimidazole resistance in veterinary nematodes. Parasitology 2007, 134:1077-1086.
24. Wolstenholme A.J., Fairweather I., Prichard R., von Samson-Himmelstjerna G., Sangster N.C. Drug resistance in veterinary helminths. Trends in Parasitology 2004, 20:469-476.