Optimization of epirubicin liposome formulation using Box-Behnken experimental design

Fudan University Journal of Medical Sciences

Volumn 34, Issue 6, 2007, Pages 816-820

  Guo, Jie ^a   Hong, Zi Wen ^a   Fang, Xiao Ling ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Box Behnken design; Epirubicin liposome; Response surface methodology

Indexed keywords

EID: 78751549095     PISSN: 16728467     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Arcamone F, Penco S, Vigevani A, et al. Synthesis and antitumor properties of new glycosides of daunomycinone and adriamycinone [J]. J Med Chem. 1975, 18 (7): 703
2. Bonadonna G, Gianni L, Santoro A, et al. Drugs ten years later: epirubicin [J]. Ann Oncol, 1993, 4 (5): 359 (Pubitemid 23193100)
3. Ferreira SLC, Bruns RE, Ferreira HS, et al. Box-Behnken design: An alternative for the optimization of analytical methods [J]. Analytica Chimica Acta, 2007, 597: 179
4. Nguyen NK, Borkowski JJ. New 3-level response surface designs constructed from incomplete block designs [J]. J Statist Plann Inference, 2007, 138 (05): 294
5. Nazzal S, Nutan M, Palamakula A, et al . Optimization of a self-nanoemulsified tablet dosage form of Ubiquinone using response surface methodology: effect of formulation ingredients [J]. Int J Pharm, 2002, 240: 103 (Pubitemid 34607707)
6. Govender S, Pillay V, Chetty DJ, et al. Optimisation and characterization of bioadhesive controlled release tetracycline microspheres [J]. Int J Pharm, 2005, 306: 24 (Pubitemid 41643138)