The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes

Biochemical Journal

Volumn 433, Issue 3, 2011, Pages 527-534

  Panayiotou, Christakis ^a   Solaroli, Nicola ^a   Xu, Yunjian ^a   Johansson, Magnus ^a   Karlsson, Anna ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adenylate kinase; Nucleotide metabolism; Nucleotide phosphorylation

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; ADENYLATE KINASE 7; ADENYLATE KINASE 8; CYTIDINE PHOSPHATE; DEOXYADENOSINE PHOSPHATE; DEOXYCYTIDINE PHOSPHATE; GREEN FLUORESCENT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SEQUENCE ALIGNMENT;

ADENYLATE KINASE; CYTOSOL; HUMANS; ISOENZYMES; KINETICS; NUCLEOTIDES; PHOSPHORYLATION; SUBSTRATE SPECIFICITY;

EID: 78751536350     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101443     Document Type: Article

References (23)

1. Dzeja, P. P., Vitkevicius, K. T., Redfield, M. M., Burnett, J. C. and Terzic, A. (1999) Adenylate kinase-catalyzed phosphotransfer in the myocardium: increased contribution in heart failure. Circ. Res. 84, 1137-1143
2. Dzeja, P. and Terzic, A. (2009) Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing. Int. J. Mol. Sci. 10, 1729-1772
3. Panayiotou, C., Solaroli, N., Johansson, M. and Karlsson, A. (2010) Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4. Int. J. Biochem. Cell Biol. 42, 62-69
4. Solaroli, N., Panayiotou, C., Johansson, M. and Karlsson, A. (2009) Identification of two active functional domains of human adenylate kinase 5. FEBS Lett. 583, 2872-2876
5. Van Rompay, A. R., Johansson, M. and Karlsson, A. (1999) Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. Eur. J. Biochem. 261, 509-517
6. Ren, H., Wang, L., Bennett, M., Liang, Y., Zheng, X., Lu, F., Li, L., Nan, J., Luo, M., Eriksson, S. et al. (2005) The crystal structure of human adenylate kinase 6: an adenylate kinase localized to the cell nucleus. Proc. Natl. Acad. Sci. U.S.A. 102, 303-308
7. Fernandez-Gonzalez, A., Kourembanas, S., Wyatt, T. A. and Mitsialis, S. A. (2009) Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype. Am. J. Respir. Cell Mol. Biol. 40, 305-313
8. Lust, J. and Sahud, M. A. (1972) Contributions of anion-exchange thin-layer chromatography to the study of free nucleotides in tissues. J. Chromatogr. 71, 127-133
9. Curbo, S., Amiri, M., Foroogh, F., Johansson, M. and Karlsson, A. (2003) The Drosophila melanogasterUMP-CMP kinase cDNA encodes an N-terminal mitochondrial import signal. Biochem. Biophys. Res. Commun. 311, 440-445
10. Wilson, D. E., Povey, S. and Harris, H. (1976) Adenylate kinases in man: evidence for a third locus. Ann. Hum. Genet. 39, 305-313
11. Noma, T., Fujisawa, K., Yamashiro, Y., Shinohara, M., Nakazawa, A., Gondo, T., Ishihara, T. and Yoshinobu, K. (2001) Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix. Biochem. J. 358, 225-232 (Pubitemid 32778117)
12. Kinukawa, M., Nomura, M. and Vacquier, V. D. (2007) A sea urchin sperm flagellar adenylate kinase with triplicated catalytic domains. J. Biol. Chem. 282, 2947-2955
13. Bianchi, P., Zappa, M., Bredi, E., Vercellati, C., Pelissero, G., Barraco, F. and Zanella, A. (1999) A case of complete adenylate kinase deficiency due to a nonsense mutation in AK-1 gene (Arg107→Stop, CGA→TGA) associated with chronic haemolytic anaemia. Br. J. Haematol. 105, 75-79
14. Pannicke, U., Honig, M., Hess, I., Friesen, C., Holzmann, K., Rump, E. M., Barth, T. F., Rojewski, M. T., Schulz, A., Boehm, T. et al. (2009) Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. Nat. Genet. 41, 101-105
15. Lagresle-Peyrou, C., Six, E. M., Picard, C., Rieux-Laucat, F., Michel, V., Ditadi, A., Demerens-de Chappedelaine, C., Morillon, E., Valensi, F., Simon-Stoos, K. L. et al. (2009) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nat. Genet. 41, 106-111
16. Lee, H. J., Pyo, J. O., Oh, Y., Kim, H. J., Hong, S. H., Jeon, Y. J., Kim, H., Cho, D. H., Woo, H. N., Song, S. et al. (2007) AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10. Nat. Cell Biol. 9, 1303-1310
17. Liu, R., Strom, A. L., Zhai, J., Gal, J., Bao, S., Gong, W. and Zhu, H. (2009) Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase. Int. J. Biochem. Cell Biol. 41, 1371-1380
18. Stanojevic, V., Habener, J. F., Holz, G. G. and Leech, C. A. (2008) Cytosolic adenylate kinases regulate K-ATP channel activity in human β-cells. Biochem. Biophys. Res. Commun. 368, 614-619
19. Tuzun, E., Rossi, J. E., Karner, S. F., Centurion, A. F. and Dalmau, J. (2007) Adenylate kinase 5 autoimmunity in treatment refractory limbic encephalitis. J. Neuroimmunol. 186, 177-180 (Pubitemid 46770870)
20. Dzeja, P. P., Bortolon, R., Perez-Terzic, C., Holmuhamedov, E. L. and Terzic, A. (2002) Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer. Proc. Natl. Acad. Sci. U.S.A. 99, 10156-10161
21. Simpson, K. J., Selfors, L. M., Bui, J., Reynolds, A., Leake, D., Khvorova, A. and Brugge, J. S. (2008) Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat. Cell Biol. 10, 1027-1038
22. Hancock, C. R., Janssen, E. and Terjung, R. L. (2006) Contraction-mediated phosphorylation of AMPK is lower in skeletal muscle of adenylate kinase-deficient mice. J. Appl. Physiol. 100, 406-413
23. Pucar, D., Bast, P., Gumina, R. J., Lim, L., Drahl, C., Juranic, N., Macura, S., Janssen, E., Wieringa, B., Terzic, A. and Dzeja, P. P. (2002) Adenylate kinase AK1 knockout heart: energetics and functional performance under ischemia-reperfusion. Am. J. Physiol. Heart Circ. Physiol. 283, H776-H782