Bacterial flavohemoglobin: A molecular tool to probe mammalian nitric oxide biology

BioTechniques

Volumn 50, Issue 1, 2011, Pages 41-45

  Forrester, Michael T ^a   Eyler, Christine E ^a,b   Rich, Jeremy N ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Escherichia coli; Flavohemoglobin; Heterologous expression; Macrophage; Metabolism; Molecular engineering; Nitric oxide

Indexed keywords

BACTERIAL PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN FLAVOHEMOGLOBIN; UNCLASSIFIED DRUG;

ARTICLE; ESCHERICHIA COLI; MAMMAL CELL; NONHUMAN;

DIHYDROPTERIDINE REDUCTASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLAVIN-ADENINE DINUCLEOTIDE; HEK293 CELLS; HEMEPROTEINS; HUMANS; LENTIVIRUS; NADH, NADPH OXIDOREDUCTASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATION-REDUCTION; SIGNAL TRANSDUCTION; TRANSFECTION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA;

EID: 78751529284     PISSN: 07366205     EISSN: 19409818     Source Type: Journal    
DOI: 10.2144/000113586     Document Type: Article

References (32)

1. Stamler, J.S., D.J. Singel, and J. Loscalzo. 1992. Biochemistry of nitric oxide and its redoxactivated forms. Science 258:1898-1902.
2. Jaffrey, S.R. and S.H. Snyder. 1995. Nitric oxide: a neural messenger. Annu. Rev. Cell Dev. Biol. 11:417-440.
3. Spiro, S. 2007. Regulators of bacterial responses to nitric oxide. FEMS Microbiol. Rev. 31:193-211.
4. Moreau, M., C. Lindermayr, J. Durner, and D.F. Klessig. 2010. NO synthesis and signaling in plants--where do we stand? Physiol. Plant. 138:372-383.
5. Fang, F.C. 2004. Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat. Rev. Microbiol. 2:820-832.
6. Nathan, C. and M.U. Shiloh. 2000. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc. Natl. Acad. Sci. USA 97:8841-8848.
7. Gardner, A.M., R.A. Helmick, and P.R. Gardner. 2002. Flavorubredoxin, an inducible catalyst for nitric oxide reduction and detoxification in Escherichia coli. J. Biol. Chem. 277:8172-8177.
8. Gardner, P.R., A.M. Gardner, L.A. Martin, and A.L. Salzman. 1998. Nitric oxide dioxygenase: an enzymic function for flavohemoglobin. Proc. Natl. Acad. Sci. USA 95:10378-10383.
9. Hausladen, A., A.J. Gow, and J.S. Stamler. 1998. Nitrosative stress: metabolic pathway involving the flavohemoglobin. Proc. Natl. Acad. Sci. USA 95:14100-14105.
10. Crawford, M.J. and D.E. Goldberg. 1998. Role for the Salmonella flavohemoglobin in protection from nitric oxide. J. Biol. Chem. 273:12543-12547.
11. Vinogradov, S.N., D. Hoogewijs, X. Bailly, K. Mizuguchi, S. Dewilde, L. Moens, and J.R. Vanfleteren. 2007. A model of globin evolution. Gene 398:132-142.
12. Richardson, A.R., P.M. Dunman, and F.C. Fang. 2006. The nitrosative stress response of Staphylococcus aureus is required for resistance to innate immunity. Mol. Microbiol. 61:927-939.
13. Sebbane, F., N. Lemaitre, D.E. Sturdevant, R. Rebeil, K. Virtaneva, S.F. Porcella, and B.J. Hinnebusch. 2006. Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague. Proc. Natl. Acad. Sci. USA 103:11766-11771.
14. Svensson, L., M. Poljakovic, S. Save, N. Gilberthorpe, T. Schon, S. Strid, H. Corker, R.K. Poole, and K. Persson. 2010. Role of flavohemoglobin in combating nitrosative stress in uropathogenic Escherichia coli--implications for urinary tract infection. Microb. Pathog. 49:59-66.
15. Turrion-Gomez, J.L., A.P. Eslava, and E.P. Benito. 2010. The flavohemoglobin BCFHG1 is the main NO detoxification system and confers protection against nitrosative conditions but is not a virulence factor in the fungal necrotroph Botrytis cinerea. Fungal Genet. Biol. 47:484-496.
16. de Jesus-Berrios, M., L. Liu, J.C. Nussbaum, G.M. Cox, J.S. Stamler, and J. Heitman. 2003. Enzymes that counteract nitrosative stress promote fungal virulence. Curr. Biol. 13:1963-1968.
17. Goncalves, V.L., L.S. Nobre, J.B. Vicente, M. Teixeira, and L.M. Saraiva. 2006. Flavohemoglobin requires microaerophilic conditions for nitrosative protection of Staphylococcus aureus. FEBS Lett. 580:1817-1821.
18. Ullmann, B.D., H. Myers, W. Chiranand, A.L. Lazzell, Q. Zhao, L.A. Vega, J.L. Lopez-Ribot, P.R. Gardner, and M.C. Gustin. 2004. Inducible defense mechanism against nitric oxide in Candida albicans. Eukaryot. Cell 3:715-723.
19. Hromatka, B.S., S.M. Noble, and A.D. Johnson. 2005. Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence. Mol. Biol. Cell 16:4814-4826.
20. Stuehr, D.J., J. Santolini, Z.Q. Wang, C.C. Wei, and S. Adak. 2004. Update on mechanism and catalytic regulation in the NO synthases. J. Biol. Chem. 279:36167-36170.
21. Garvey, E.P., J.A. Oplinger, E.S. Furfine, R.J. Kiff, F. Laszlo, B.J. Whittle, and R.G. Knowles. 1997. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J. Biol. Chem. 272:4959-4963.
22. Strub, A., W.R. Ulrich, C. Hesslinger, M. Eltze, T. Fuchss, J. Strassner, S. Strand, M.D. Lehner, and R. Boer. 2006. The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitricoxide synthase. Mol. Pharmacol. 69:328-337.
23. Bogle, R.G., R.J. MacAllister, G.S. Whitley, and P. Vallance. 1995. Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthases? Am. J. Physiol. 269:C750-C756.
24. DeGeorge, G.L., D.E. Heck, and J.D. Laskin. 1997. Arginine metabolism in keratinocytes and macrophages during nitric oxide biosynthesis: multiple modes of action of nitricoxide synthase inhibitors. Biochem. Pharmacol. 54:103-112.
25. MacAllister, R.J., S.A. Fickling, G.S. Whitley, and P. Vallance. 1994. Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis. Br. J. Pharmacol. 112:43-48.
26. Gardner, A.M., L.A. Martin, P.R. Gardner, Y. Dou, and J.S. Olson. 2000. Steadystate and transient kinetics of Escherichia coli nitric-oxide dioxygenase (flavohemoglobin). The B10 tyrosine hydroxyl is essential for dioxygen binding and catalysis. J. Biol. Chem. 275:12581-12589.
27. Stuehr, D.J., H.J. Cho, N.S. Kwon, M.F. Weise, and C.F. Nathan. 1991. Purification and characterization of the cytokineinduced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proc. Natl. Acad. Sci. USA 88:7773-7777.
28. Stuehr, D.J. and M.A. Marletta. 1985. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. USA 82:7738-7742.
29. Stuehr, D.J. and M.A. Marletta. 1987. Synthesis of nitrite and nitrate in murine macrophage cell lines. Cancer Res. 47:5590-5594.
30. Forrester, M.T., D. Seth, A. Hausladen, C.E. Eyler, M.W. Foster, A. Matsumoto, M. Benhar, H.E. Marshall, and J.S. Stamler. 2009. Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation. J. Biol. Chem. 284:36160-36166.
31. Oelze, M., H. Mollnau, N. Hoffmann, A. Warnholtz, M. Bodenschatz, A. Smolenski, U. Walter, M. Skatchkov, et al. 2000. Vasodilatorstimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction. Circ. Res. 87:999-1005.
32. Habib, A., C. Bernard, M. Lebret, C. Creminon, B. Esposito, A. Tedgui, and J. Maclouf. 1997. Regulation of the expression of cyclooxygenase-2 by nitric oxide in rat peritoneal macrophages. J. Immunol. 158:3845-3851.