Submucosal gland development in the human fetal trachea xenograft model: Implications for fetal gene therapy

Journal of Pediatric Surgery

Volumn 46, Issue 1, 2011, Pages 33-38

  Keswani, Sundeep G ^a,b   Le, Louis D ^a   Morris, Lee M ^a   Lim, Foong Yen ^a,b   Katz, Anna B ^b   Ghobril, Nabil ^a   Habli, Mounira ^a   Frischer, Jason S ^a   Crombleholme, Timothy M ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Cystic fibrosis; Fetal gene therapy; Human fetal tracheal xenograft

Indexed keywords

GLYCOSAMINOGLYCAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; GENE THERAPY; GENE TRANSFER; GLYCOSAMINOGLYCAN METABOLISM; HUMAN; HUMAN TISSUE; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; SUBMUCOSA; TRACHEA MUCOSA; XENOGRAFT;

ANIMALS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EXOCRINE GLANDS; FEMALE; FETAL THERAPIES; FETAL TISSUE TRANSPLANTATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GLYCOSAMINOGLYCANS; HUMANS; MICE; MICE, INBRED CFTR; PREGNANCY; TRACHEA; TRANSPLANTATION, HETEROLOGOUS;

EID: 78751486420     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2010.09.064     Document Type: Article

References (13)

1. Griesenbach U., and Alton E.W. UK cystic fibrosis gene therapy consortium: gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy Adv Drug Deliv Rev 61 2 2009 128 139
2. Engelhardt J.F., Yankaskas J.R., and Ernst S.A. Submucosal glands are the predominant site of CFTR expression in the human bronchus Nat Genet 2 1992 240 248
3. Duan D., Sehgal A., and Yao J. Lef1 transcription factor expression defines airway progenitor cell targets for in utero gene therapy of submucosal gland in cystic fibrosis Am J Respir Cell Mol Biol 18 1998 750 758
4. Flotte T.R., Fischer A.C., and Goetzmann J. Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway Mol Ther 18 3 2010 594 600
5. Lim F.Y., Kobinger G.P., and Weiner D.J. Human fetal trachea-SCID mouse xenografts: efficacy of vesicular stomatitis virus-G pseudotyped lentiviral-mediated gene transfer J Pediatr Surg 38 2003 834 839
6. Lim F.Y., Kobinger G.P., and Weiner D.J. Filovirus-pseudotyped lentiviral mediated gene transfer in human fetal trachea xenografts Mol Ther 5 2002 S36
7. Keswani S.G., and Crombleholme T.M. Gene transfer to the tracheobronchial tree: implications for fetal gene therapy for cystic fibrosis Semin Pediatr Surg 13 1 2004 44 52
8. Thurlbeck W.M., Benjamin B., and Reid L. Development and distribution of mucous gland in the foetal human trachea Br J Dis Chest 55 1961 54 64
9. Liechty K.W., Kim H.B., and Adzick N.S. Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair J Ped Surg 35 2000 866 872
10. Lorenz H.P., Longaker M.T., and Perkocha L.A. Scarless wound repair: a human fetal skin model Development 114 1992 253 259
11. Liu X., Luo M., and Trygg C. Biological differences in rAAV transduction of airway epithelia in humans and in old world non-human primates Mol Ther 15 2007 2114 2123
12. Liu X., Yan Z., and Luo M. Species-specific differences in mouse and human airway epithelial biology of recombinant adeno-associated virus transduction Am J Respir Cell Mol Biol 34 2006 56 64
13. Bouchard S., Mackenzie T., and Radu A.P. Long term transgene expression in cardiac and skeletal muscle following fetal administration of adenoviral or adeno associated viral vectors in mice J Gene Med 5 11 2003 941 950