Computational prediction and experimental validation associating FABP-1 and pancreatic adenocarcinoma with diabetes

BMC Gastroenterology

Volumn 11, Issue , 2011, Pages

  Sharaf, Ravi N ^a   Butte, Atul J ^a,b   Montgomery, Kelli D ^a   Pai, Reetesh ^a   Dudley, Joel T ^a,b   Pasricha, Pankaj J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LUCILE PACKARD CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 1; UNCLASSIFIED DRUG; FABP1 PROTEIN, HUMAN;

AGE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; GENOMICS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ADENOCARCINOMA; PREDICTION; TISSUE MICROARRAY; ADENOCARCINOMA; ADULT; AGED; BIOLOGY; GENETICS; METABOLISM; MIDDLE AGED; PANCREAS TUMOR; PILOT STUDY; PREDICTIVE VALUE; PROTEIN MICROARRAY; STATISTICAL MODEL; VALIDATION STUDY;

ADENOCARCINOMA; ADULT; AGED; COMPUTATIONAL BIOLOGY; DIABETES COMPLICATIONS; DIABETES MELLITUS; FATTY ACID-BINDING PROTEINS; FEMALE; GENOMICS; HUMANS; IMMUNOHISTOCHEMISTRY; LOGISTIC MODELS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PILOT PROJECTS; PREDICTIVE VALUE OF TESTS; PROTEIN ARRAY ANALYSIS;

EID: 78651543827     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-11-5     Document Type: Article

References (47)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J. Cancer statistics, 2009. CA Cancer J Clin 2009, 59:225-249. 10.3322/caac.20006, 19474385.
2. Klimstra DS. Nonductal neoplasms of the pancreas. Mod Pathol 2007, 20(Suppl 1):S94-112. 10.1038/modpathol.3800686, 17486055.
3. Pannala R, Basu A, Petersen GM, Chari ST. New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer. Lancet Oncol 2009, 10(1):88-95. 10.1016/S1470-2045(08)70337-1, 2795483, 19111249.
4. Chari ST, Leibson CL, Rabe KG, Ransom J, de Andrade M, Petersen GM. Probability of pancreatic cancer following diabetes: a population-based study. Gastroenterology 2005, 129(2):504-511. 2377196, 16083707.
5. Pfeffer F, Koczan D, Adam U, Benz S, von Dobschuetz E, Prall F, Nizze H, Thiesen H-J, Hopt UT, Löbler M. Expression of connexin26 in islets of Langerhans is associated with impaired glucose tolerance in patients with pancreatic adenocarcinoma. Pancreas 2004, 29(4):284-290. 10.1097/00006676-200411000-00007, 15502644.
6. Krechler T, Jachymova M, Pavlikova M, Vecka M, Zeman M, Krska Z, Svestka T, Zak A. Polymorphism -23HPhI in the promoter of insulin gene and pancreatic cancer: a pilot study. Neoplasma 2009, 56(1):26-32. 10.4149/neo_2009_01_26, 19152242.
7. Kolb A, Rieder S, Born D, Giese NA, Giese T, Rudofsky G, Werner J, Büchler MW, Friess H, Esposito I, et al. Glucagon/insulin ratio as a potential biomarker for pancreatic cancer in patients with new-onset diabetes mellitus. Cancer Biol Ther 2009, 8(16):1527-1533.
8. Basso D, Greco E, Fogar P, Pucci P, Flagiello A, Baldo G, Giunco S, Valerio A, Navaglia F, Zambon C-F, et al. Pancreatic cancer-derived S-100A8 N-terminal peptide: a diabetes cause?. Clin Chim Acta 2006, 372(1-2):120-128. 10.1016/j.cca.2006.03.027, 16678810.
9. Permert J, Larsson J, Westermark GT, Herrington MK, Christmanson L, Pour PM, Westermark P, Adrian TE. Islet amyloid polypeptide in patients with pancreatic cancer and diabetes. N Engl J Med 1994, 330(5):313-318. 10.1056/NEJM199402033300503, 8277951.
10. Basso D, Plebani M, Fogar P, Panozzo MP, Meggiato T, De Paoli M, Del Favero G. Insulin-like growth factor-I, interleukin-1 alpha and beta in pancreatic cancer: role in tumor invasiveness and associated diabetes. Int J Clin Lab Res 1995, 25(1):40-43. 10.1007/BF02592575, 7787209.
11. Dudley JT, Butte AJ. Identification of discriminating biomarkers for human disease using integrative network biology. Pac Symp Biocomput 2009, 27-38. 2749008, 19209693.
12. English SB, Butte AJ. Evaluation and integration of 49 genome-wide experiments and the prediction of previously unknown obesity-related genes. Bioinformatics 2007, 23(21):2910-2917. 10.1093/bioinformatics/btm483, 2839901, 17921495.
13. Dudley JT, Tibshirani R, Deshpande T, Butte AJ. Disease signatures are robust across tissues and experiments. Mol Syst Biol 2009, 5:307. 10.1038/msb.2009.66, 2758720, 19756046.
14. Chen R. Finding Disease-Related Genomic Experiments Within an International Repository: First Steps in Translational Bioinformatics. AMIA Annual Symposium Proceedings 2006, 106-110. 1839582, 17238312.
15. Bodenreider O. The Unified Medical Language System (UMLS): integrating biomedical terminology. Nucleic Acids Research 2004, 32(Database):D267-270. 10.1093/nar/gkh061, 308795, 14681409.
16. Dudley J, Butte AJ. Enabling integrative genomic analysis of high-impact human diseases through text mining. Pac Symp Biocomput 2008, 580-591. 2735266, 18229717.
17. Becker KG, Barnes KC, Bright TJ, Wang SA. The genetic association database. Nat Genet 2004, 36(5):431-432. 10.1038/ng0504-431, 15118671.
18. Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, et al. The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 2004, 3(4):311-326. 10.1074/mcp.M300127-MCP200, 14718574.
19. Zhang Y, Zhang Y, Adachi J, Olsen JV, Shi R, de Souza G, Pasini E, Foster LJ, Macek B, Zougman A, et al. MAPU: Max-Planck Unified database of organellar, cellular, tissue and body fluid proteomes. Nucleic Acids Res 2007, 35(Database):D771-779. 10.1093/nar/gkl784, 1781136, 17090601.
20. Pisitkun T, Shen R-F, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA 2004, 101(36):13368-13373. 10.1073/pnas.0403453101, 516573, 15326289.
21. Marinelli RJ, Montgomery K, Liu CL, Shah NH, Prapong W, Nitzberg M, Zachariah ZK, Sherlock GJ, Natkunam Y, West RB, et al. The Stanford Tissue Microarray Database. Nucleic Acids Res 2008, 36(Database):D871-877. 10.1093/nar/gkm861, 2238948, 17989087.
22. Lehman NL, van de Rijn M, Jackson PK. Screening of tissue microarrays for ubiquitin proteasome system components in tumors. Meth Enzymol 2005, 399:334-355. 10.1016/S0076-6879(05)99023-X, 16338367.
23. Wapnir IL, van de Rijn M, Nowels K, Amenta PS, Walton K, Montgomery K, Greco RS, Dohán O, Carrasco N. Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections. J Clin Endocrinol Metab 2003, 88(4):1880-1888. 10.1210/jc.2002-021544, 12679487.
24. Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov 2008, 7(6):489-503. 10.1038/nrd2589, 2821027, 18511927.
25. Lawrie LC, Dundas SR, Curran S, Murray GI. Liver fatty acid binding protein expression in colorectal neoplasia. Br J Cancer 2004, 90(10):1955-1960. 10.1038/sj.bjc.6601828, 2409459, 15138477.
26. Yamazaki T, Kanda T, Sakai Y, Hatakeyama K. Liver fatty acid-binding protein is a new prognostic factor for hepatic resection of colorectal cancer metastases. J Surg Oncol 1999, 72(2):83-87. 10.1002/(SICI)1096-9098(199910)72:2<83::AID-JSO87>3.0.CO;2-C, 10518104.
27. Pei H, Zhu H, Zeng S, Li Y, Yang H, Shen L, Chen J, Zeng L, Fan J, Li X, et al. Proteome analysis and tissue microarray for profiling protein markers associated with lymph node metastasis in colorectal cancer. J Proteome Res 2007, 6(7):2495-2501. 10.1021/pr060644r, 17542627.
28. Smirnov DA, Zweitzig DR, Foulk BW, Miller MC, Doyle GV, Pienta KJ, Meropol NJ, Weiner LM, Cohen SJ, Moreno JG, et al. Global gene expression profiling of circulating tumor cells. Cancer Res 2005, 65(12):4993-4997. 10.1158/0008-5472.CAN-04-4330, 15958538.
29. Lyall MS, Dundas SR, Curran S, Murray GI. Profiling markers of prognosis in colorectal cancer. Clin Cancer Res 2006, 12(4):1184-1191. 10.1158/1078-0432.CCR-05-1864, 16489072.
30. Hashimoto T, Kusakabe T, Watanabe K, Sugino T, Fukuda T, Nashimoto A, Honma K-I, Sato Y, Kimura H, Fujii H, et al. Liver-type fatty acid-binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma. Pathobiology 2004, 71(3):115-122. 10.1159/000076465, 15051923.
31. Suzuki T, Watanabe K, Ono T. Immunohistochemical demonstration of liver fatty acid-binding protein in human hepatocellular malignancies. J Pathol 1990, 161(1):79-83. 10.1002/path.1711610113, 2164578.
32. Harsha HC, Kandasamy K, Ranganathan P, Rani S, Ramabadran S, Gollapudi S, Balakrishnan L, Dwivedi SB, Telikicherla D, Selvan LDN, et al. A compendium of potential biomarkers of pancreatic cancer. PLoS Med 2009, 6(4):e1000046. 10.1371/journal.pmed.1000046, 2661257, 19360088.
33. Martin GG, Atshaves BP, McIntosh AL, Payne HR, Mackie JT, Kier AB, Schroeder F. Liver fatty acid binding protein gene ablation enhances age-dependent weight gain in male mice. Mol Cell Biochem 2009, 324(1-2):101-115. 10.1007/s11010-008-9989-9, 2835309, 19104910.
34. Martin GG, Atshaves BP, McIntosh AL, Mackie JT, Kier AB, Schroeder F. Liver fatty acid-binding protein gene-ablated female mice exhibit increased age-dependent obesity. J Nutr 2008, 138(10):1859-1865. 2835297, 18806093.
35. Newberry EP, Kennedy SM, Xie Y, Sternard BT, Luo J, Davidson NO. Diet-induced obesity and hepatic steatosis in L-Fabp/mice is abrogated with SF, but not PUFA, feeding and attenuated after cholesterol supplementation. Am J Physiol Gastrointest Liver Physiol 2008, 294(1):G307-314. 10.1152/ajpgi.00377.2007, 18032478.
36. Newberry EP, Xie Y, Kennedy SM, Luo J, Davidson NO. Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Hepatology 2006, 44(5):1191-1205. 10.1002/hep.21369, 17058218.
37. Magnusson AL, Waterman IJ, Wennergren M, Jansson T, Powell TL. Triglyceride hydrolase activities and expression of fatty acid binding proteins in the human placenta in pregnancies complicated by intrauterine growth restriction and diabetes. J Clin Endocrinol Metab 2004, 89(9):4607-4614. 10.1210/jc.2003-032234, 15356070.
38. Rowley CW, Staloch LJ, Divine JK, McCaul SP, Simon TC. Mechanisms of mutual functional interactions between HNF-4alpha and HNF-1alpha revealed by mutations that cause maturity onset diabetes of the young. Am J Physiol Gastrointest Liver Physiol 2006, 290(3):G466-475. 10.1152/ajpgi.00431.2005, 16223942.
39. Wolfrum C, Borrmann CM, Borchers T, Spener F. Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus. Proc Natl Acad Sci USA 2001, 98(5):2323-2328. 10.1073/pnas.051619898, 30137, 11226238.
40. Fisher E, Weikert C, Klapper M, Lindner I, Möhlig M, Spranger J, Boeing H, Schrezenmeir J, Döring F. L-FABP T94A is associated with fasting triglycerides and LDL-cholesterol in women. Mol Genet Metab 2007, 91(3):278-284. 10.1016/j.ymgme.2007.03.002, 17485234.
41. Ishimitsu T, Ohta S, Saito M, Teranishi M, Inada H, Yoshii M, Minami J, Ono H, Hikawa A, Shibata N, et al. Urinary excretion of liver fatty acid-binding protein in health-check participants. Clin Exp Nephrol 2005, 9(1):34-39. 10.1007/s10157-004-0331-x, 15830271.
42. Portilla D, Dent C, Sugaya T, Nagothu KK, Kundi I, Moore P, Noiri E, Devarajan P. Liver fatty acid-binding protein as a biomarker of acute kidney injury after cardiac surgery. Kidney Int 2008, 73(4):465-472. 10.1038/sj.ki.5002721, 18094680.
43. Lachmann RA, Werchan S, Schachtrup C, Haitsma JJ, Spener F, Lachmann B. Liver-type fatty acid binding protein in serum and broncho-alveolar lavage in a model of acute respiratory failure because of surfactant depletion--a possible marker for lung damage?. Clin Physiol Funct Imaging 2006, 26(6):371-375. 10.1111/j.1475-097X.2006.00703.x, 17042904.
44. Piumngam P, Schachtrup C, Owada Y, Kondo H, Promptmas C, Spener F. Expression of liver-type fatty acid-binding protein in murine lung and its release into serum upon challenge of lung with lipopolysaccharide. Eur J Lipid Sci Technol 2005, 107(1):145-152.
45. Lifesciences U. , http://www.uscnk.com/directory/Fatty-acid-binding-protein-1-Liver(FABP1)-1566.htm
46. Biosciences L. , http://www.lsbio.com/Products/GeneDetail.aspx?LSID=1627
47. Laboratories SC. , http://www.scbt.com/table-l-fabp.html