Preventing osteoporosis with a tissue selective estrogen complex (TSEC) containing bazedoxifene/conjugated estrogens (BZA/CE)

Osteoporosis International

Volumn 22, Issue 2, 2011, Pages 447-451

  Lindsay, R ^a  

^a NONE

Author keywords

Bazedoxifene; Bone; Conjugated estrogens; Menopause; Tissue selective estrogen complex; TSEC

Indexed keywords

BAZEDOXIFENE; BAZEDOXIFENE PLUS CONJUGATED ESTROGEN; CONJUGATED ESTROGEN; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; HORMONE RECEPTOR STIMULATING AGENT; LASOFOXIFENE; PLACEBO; RALOXIFENE; TISSUE SELECTIVE ESTROGEN COMPLEX; UNCLASSIFIED DRUG;

AMENORRHEA; BONE MASS; BONE REMODELING; CARDIOVASCULAR DISEASE; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG POTENCY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; HIGH RISK POPULATION; HORMONAL THERAPY; HOT FLUSH; HUMAN; NONHUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; VAGINA ATROPHY; VEIN THROMBOSIS;

BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CLINICAL TRIALS, PHASE III AS TOPIC; COLLAGEN TYPE I; ENDOMETRIUM; ESTROGENS, CONJUGATED (USP); FEMALE; HOT FLASHES; HUMANS; INDOLES; MENOPAUSE; OSTEOPOROSIS, POSTMENOPAUSAL; PEPTIDES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TREATMENT OUTCOME; VAGINAL DISEASES;

EID: 78651514354     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-010-1440-x     Document Type: Review

References (16)

1. TJ Berrodin KC Chang BS Komm LP Freedman S Nagpal 2009 Differential biochemical and cellular actions of premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination Mol Endocrinol 23 74 85 1:CAS:528:DC%2BD1MXnsFOitg%3D%3D 10.1210/me.2008-0366 19036900
2. Y Kharode PVN Bodine CP Miller CR Lyttle BS Komm 2008 The pairing of a selective estrogen receptor modulator, bazedoxifene, with conjugated estrogens as a new paradigm for the treatment of menopausal symptoms and osteoporosis prevention Endocrinology 149 6084 6091 1:CAS:528:DC%2BD1cXhsVGltrrI 10.1210/en.2008-0817 18703623
3. BJ Peano JS Crabtree BS Komm RC Winneker HA Harris 2009 Effects of various selective estrogen receptor modulators with or without conjugated estrogens on mouse mammary gland Endocrinology 150 1897 1903 1:CAS:528:DC%2BD1MXktVWlsLs%3D 10.1210/en.2008-1210 19022889
4. Komm BS, Pickar JH (2006) Tissue selective estrogen complex (TSEC): a new paradigm for menopausal therapy. Complete proceedings collection of the 6th International Menopause Society Workshop Menopause and Ageing, Quality of Life and Sexuality, Pisa, Italy, December 1-12
5. JH Pickar I-T Yeh G Bachmann L Speroff 2009 Endometrial effects of a tissue selective estrogen complex (TSEC) containing bazedoxifene/conjugated estrogens as a menopausal therapy Fertil Steril 92 1018 1024 1:CAS:528:DC%2BD1MXhsFaqtb7I 10.1016/j.fertnstert.2009.05.094 19635613
6. RA Lobo JV Pinkerton MLS Gass MH Dorin S Ronkin JH Pickar G Constantine 2009 Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic bone parameters and overall safety profile Fertil Steril 92 1025 1038 1:CAS:528:DC%2BD1MXhsFaqtb7J 10.1016/j.fertnstert.2009.03.113 19635615
7. DF Archer V Lewis BR Carr S Olivier JH Pickar 2009 Bazedoxifene/ conjugated estrogens (BZA/CE): incidence of uterine bleeding in postmenopausal women Fertil Steril 92 1039 1044 1:CAS:528:DC%2BD1MXhsFaqtb7K 10.1016/j.fertnstert.2009.05.093 19635614
8. R Lindsay JC Gallagher R Kagan JH Pickar G Constantine 2009 Efficacy of tissue-selective estrogen complex (TSEC) of bazedoxifene/conjugated estrogens (BZA/CE) for osteoporosis prevention in at-risk postmenopausal women Fertil Steril 92 1045 1052 1:CAS:528:DC%2BD1MXhsFaqtb7L 10.1016/j.fertnstert.2009.02. 093 19635616
9. R Lindsay JC Gallagher M Kleerekoper JH Pickar 2002 Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women JAMA 287 2668 2676 1:CAS:528: DC%2BD38XjvVygtbg%3D 10.1001/jama.287.20.2668 12020302
10. R Lindsay JC Gallagher M Kleerekoper JH Pickar 2005 Bone response to treatment with lower doses of conjugated estrogens with and without medroxyprogesterone acetate in early postmenopausal women Osteoporos Int 16 372 379 1:CAS:528:DC%2BD2MXisVCitrg%3D 10.1007/s00198-004-1773-4 15654581
11. JV Pinkerton WH Utian GD Constantine S Olivier JH Pickar 2009 Relief of vasomotor symptoms with the tissue selective estrogen complex (TSEC) containing bazedoxifene/conjugated estrogens: a randomized, controlled trial Menopause 16 1116 1124 10.1097/gme.0b013e3181a7df0d 19546826
12. R Kagan RS Williams K Pan S Mirkin JH Pickar 2010 A randomized, placebo- and active-controlled trial of bazedoxifene/conjugated estrogens (BZA/CE) for treatment of moderate to severe vulvar/vaginal atrophy in postmenopausal women Menopause 17 281 289 10.1097/gme.0b013e3181b7c65f 19779382
13. DF Archer M Dorin V Lewis DL Schneider JH Pickar 2001 Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on endometrial bleeding Fertil Steril 75 1080 1087 1:STN:280:DC%2BD3MzhtFynsQ%3D%3D 10.1016/S0015-0282(01)01792-7 11384630
14. RA Lobo JH Pickar RA Wild B Walsh E Hirvonen 1994 Metabolic impact of adding medroxyprogesterone acetate to conjugated estrogen therapy in postmenopausal women. The Menopause Study Group Obstet Gynecol 84 987 995 1:CAS:528:DyaK2MXis1Wiu78%3D 7970483
15. Writing Group for the PEPI Trial 1995 Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial JAMA 273 199 208 10.1001/jama.273.3.199
16. RA Lobo T Bush BR Carr JH Pickar 2001 Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on plasma lipids and lipoproteins, coagulation factors, and carbohydrate metabolism Fertil Steril 76 13 24 1:STN:280:DC%2BD3MzosVGrsA%3D%3D 10.1016/S0015-0282(01)01829-5 11438314