Evidence for a trianion intermediate in the metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid. methodology and application to racemic 5,5′-didesisopropyl-5,5′-dialkylapogossypol derivatives

Journal of Organic Chemistry

Volumn 76, Issue 2, 2011, Pages 601-608

  Le, Tin Thanh ^a   Chau, Nguyet Trang Thanh ^a,b   Nguyen, Tai Tan ^a   Brien, Josselin ^a   Thai, Trieu Tien ^a   Nourry, Arnaud ^a   Castanet, Anne Sophie ^a   Nguyen, Kim Phi Phung ^b   Mortier, Jacques ^a  

^a UNIVERSITÉ DU MAINE   (France)

^b HO CHI MINH CITY UNIVERSITY OF EDUCATION   (Viet Nam)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIAPOPTOTIC; BCL-2 FAMILY PROTEINS; EFFICIENT CONSTRUCTION; METALATIONS; NAPHTHOIC ACIDS; REGIO-SELECTIVE;

3 METHYL 5 PROPYL 2 (1,6,7 TRIHYDROXY 3 METHYL 5 PROPYLNAPHTHALEN 2 YL)NAPHTHALENE 1,6,7 TRIOL; 3,5 DIMETHYL 2 (1,6,7 TRIHYDROXY 3,5 DIMETHYLNAPHTHALEN 2 YL)NAPHTHALENE 1,6,7 TRIOL; 4 HYDROXY 6,7 DIMETHOXY 8 METHYL 2 NAPHTHOIC ACID; 5 ETHYL 2 (5 ETHYL 1,6,7 TRIHYDROXY 3 METHYLNAPHTHALEN 2 YL) 3 METHYLNAPHTHALENE 1,6,7 TRIOL; 5,5' DIDESISOPROPYL 5,5' DIALKYLAPOGOSSYPOL DERIVATIVE; ANTINEOPLASTIC AGENT; NAPHTHALENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS;

ANIMALS; ANIONS; APOPTOSIS; GOSSYPOL; LITHIUM COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; METALS; MICE; MOLECULAR STRUCTURE; NAPHTHALENES; PROTO-ONCOGENE PROTEINS C-BCL-2; STEREOISOMERISM;

EID: 78651501577     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo102147s     Document Type: Article

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