Melanoma and viagra: An unexpected connection

Pigment Cell and Melanoma Research

Volumn 24, Issue 1, 2011, Pages 16-18

  Mitra, Devarati ^a   Robinson, Kathleen C ^a   Fisher, David E ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CYCLIC GMP; PHOSPHODIESTERASE; PHOSPHODIESTERASE 5A; SILDENAFIL; TADALAFIL; UNCLASSIFIED DRUG; VARDENAFIL;

DRUG ACTIVITY; DRUG HALF LIFE; DRUG MECHANISM; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; MELANOMA; MICROARRAY ANALYSIS; NONHUMAN; NOTE;

ANIMALS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; HUMANS; MELANOMA; MICE; NEOPLASM INVASIVENESS; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PROTO-ONCOGENE PROTEINS B-RAF; PURINES; SULFONES;

EID: 78651461212     PISSN: 17551471     EISSN: 1755148X     Source Type: Journal    
DOI: 10.1111/j.1755-148X.2010.00819.x     Document Type: Note

References (5)

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2. Flaherty, K.T., Puzanov, I., Kim, K.B. et al. (2010). Inhibition of mutated, activated BRAF in metastatic melanoma. N. Engl. J. Med. 363, 809-819.
3. Goodall, J., Carreira, S., Denat, L., Kobi, D., Davidson, I., Nuciforo, P., Sturm, R.A., Larue, L., and Goding, C.R. (2008). Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia associated transcription factor-negative melanoma cells. Cancer Res. 68, 7788-7794.
4. Packer, L.M., East, P., Reis-Filho, J.S., and Marais, R. (2009). Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma. Pigment Cell Melanoma Res. 22, 785-798.
5. Pinner, S., Jordan, P., Sharrock, K., Bazley, L., Collinson, L., Marais, R., Bonvin, E., Goding, C., and Sahai, E. (2009). Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination. Cancer Res. 69, 7969-7977.